Regulon – gbmMINER Portal

Regulon: R-460

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
67	0.948879	1	0	Pr-108

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
10368	ENSG00000006116	CACNG3	O60359
6853	ENSG00000008056	SYN1	P17600
23154	ENSG00000020129	NCDN	Q9UBB6
535	ENSG00000033627	ATP6V0A1	B7Z641
5923	ENSG00000058335	RASGRF1	Q13972
6857	ENSG00000067715	SYT1	F8VZY3
29953	ENSG00000072657	TRHDE	H0YHU0
22999	ENSG00000079841	RIMS1	Q86UR5
23259	ENSG00000085788	DDHD2	O94830
1114	ENSG00000089199	CHGB	P05060
4744	ENSG00000100285	NEFH	P12036
6855	ENSG00000102003	SYP	P08247
3356	ENSG00000102468	HTR2A	P28223
1428	ENSG00000103316	CRYM	Q14894
4741	ENSG00000104722	NEFM	P07197
57030	ENSG00000104888	SLC17A7	Q9P2U7
478	ENSG00000105409	ATP1A3	P13637
3780	ENSG00000105642	KCNN1	Q92952
10900	ENSG00000108309	RUNDC3A	Q59EK9
11275	ENSG00000109466	KLHL2	O95198
887	ENSG00000110148	CCKBR	P32239
8437	ENSG00000111344	RASAL1	O95294
2566	ENSG00000113327	GABRG2	A8MWU7
2744	ENSG00000115419	GLS	B7Z509
51440	ENSG00000116983	HPCAL4	Q9UM19
6543	ENSG00000118160	SLC8A2	Q9UPR5
2805	ENSG00000120053	GOT1	P17174
3208	ENSG00000121905	HPCA	P84074
9956	ENSG00000122254	HS3ST2	Q9Y278
57468	ENSG00000124140	SLC12A5	Q9H2X9
5126	ENSG00000125851	PCSK2	P16519
10439	ENSG00000130558	OLFM1	Q99784
6616	ENSG00000132639	SNAP25	P60880
27165	ENSG00000135423	GLS2	G5E9X4
23017	ENSG00000135472	FAIM2	Q9BWQ8
9764	ENSG00000135709	KIAA0513	O60268
6326	ENSG00000136531	SCN2A	Q99250
5530	ENSG00000138814	PPP3CA	Q08209
6622	ENSG00000145335	SNCA	H6UYS0
54438	ENSG00000145990	GFOD1	S4R302
2830	ENSG00000146360	GPR6	F1DAM6
9118	ENSG00000148798	INA	Q16352
22866	ENSG00000149970	CNKSR2	Q8WXI2
57338	ENSG00000154118	JPH3	Q8WXH2
3798	ENSG00000155980	KIF5A	Q12840
23362	ENSG00000156011	PSD3	Q9NYI0
23057	ENSG00000157064	NMNAT2	Q9BZQ4
9478	ENSG00000157782	CABP1	Q9NZU7
79012	ENSG00000164076	CAMKV	A0A024R331
9607	ENSG00000164326	CARTPT	Q16568
55800	ENSG00000166257	SCN3B	Q9NY72
7480	ENSG00000169884	WNT10B	O00744
8507	ENSG00000171617	ENC1	Q53XS2
6623	ENSG00000173267	SNCG	O76070
64837	ENSG00000174996	KLC2	Q9H0B6
8851	ENSG00000176749	CDK5R1	Q15078
8541	ENSG00000177380	PPFIA3	O75145
6000	ENSG00000182901	RGS7	P49802
4675	ENSG00000186310	NAP1L3	Q99457
5138	ENSG00000186642	PDE2A	O00408
2563	ENSG00000187730	GABRD	O14764
6334	ENSG00000196876	SCN8A	Q9UQD0
192683	ENSG00000198794	SCAMP5	H3BP89
22876	ENSG00000198825	INPP5F	Q9Y2H2
9853	ENSG00000198853	RUSC2	Q8N2Y8
1113	ENSG00000276781	CHGA	P10645
4747	ENSG00000277586	NEFL	P07196

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
PIMOZIDE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
ROPIVACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MIDAZOLAM HYDROCHLORIDE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
PROMAZINE	HTR2A	Small molecule	ANTAGONIST	D2-like dopamine receptor antagonist	4	0
LOXAPINE	HTR2A	Small molecule	ANTAGONIST	D2-like dopamine receptor antagonist	4	0
MORICIZINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUETIAPINE FUMARATE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2c (5-HT2c) receptor antagonist	4	0
CHLORDIAZEPOXIDE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ALPRAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ESTAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
TERODILINE	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
PHENYTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CLOZAPINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
QUINIDINE POLYGALACTURONATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ACAMPROSATE CALCIUM	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
FOSPHENYTOIN SODIUM	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ONABOTULINUMTOXINA	SNAP25	Unknown	INHIBITOR	Synaptosomal-associated protein 25 inhibitor	4	0
MIDAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
CHLOROPROCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
TEDATIOXETINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2c (5-HT2c) receptor antagonist	2	0
BLONANSERIN	HTR2A	Small molecule	ANTAGONIST	Dopamine D2 receptor antagonist	3	0
ETIFOXINE	GABRG2	Small molecule	ANTAGONIST	GABA-A receptor; anion channel antagonist	3	0
ZIMELDINE	HTR1B	Small molecule	ANTAGONIST	Serotonin (5-HT) receptor antagonist	4	0
ENCAINIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ZIPRASIDONE MESYLATE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2c (5-HT2c) receptor antagonist	4	0
THIORIDAZINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2c (5-HT2c) receptor antagonist	4	0
BREXPIPRAZOLE	HTR2A	Small molecule	PARTIAL AGONIST	Dopamine D2 receptor partial agonist	4	0
ARIPIPRAZOLE LAUROXIL	HTR2A	Small molecule	PARTIAL AGONIST	Serotonin 1a (5-HT1a) receptor partial agonist	4	0
ESLICARBAZEPINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PROCAINAMIDE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MIRTAZAPINE	ADRA2B	Small molecule	ANTAGONIST	Adrenergic receptor alpha-2 antagonist	4	0
THIOPENTAL SODIUM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ESZOPICLONE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ARIPIPRAZOLE	HTR2A	Small molecule	PARTIAL AGONIST	Dopamine D2 receptor partial agonist	4	0
THIOTHIXENE	HTR2A	Small molecule	ANTAGONIST	Dopamine D2 receptor antagonist	4	0
TRAZODONE HYDROCHLORIDE	HTR2A	Small molecule	INHIBITOR	Serotonin transporter inhibitor	4	0
MEPHENYTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PALIPERIDONE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ILOPERIDONE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
PRUVANSERIN	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	2	0
PRAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
PROCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
LANATOSIDE C	ATP1A1	Small molecule	INHIBITOR	Sodium/potassium-transporting ATPase inhibitor	4	0
CHLORPROMAZINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	2
PROPAFENONE HYDROCHLORIDE	ADRB2	Small molecule	ANTAGONIST	Beta-1 adrenergic receptor antagonist	4	0
OLANZAPINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
ROPIVACAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
FLUMAZENIL	GABRG2	Small molecule	ALLOSTERIC ANTAGONIST	GABA-A receptor; anion channel allosteric antagonist	4	0
PENTOXIFYLLINE	PDE4A	Small molecule	ANTAGONIST	Adenosine A2 receptor antagonist	4	0
SERTINDOLE	HTR2A	Small molecule	ANTAGONIST	Adrenergic receptor alpha-1 antagonist	4	0
RESEQUINIL	GABRG2	Small molecule	INVERSE AGONIST	GABA-A receptor; anion channel inverse agonist	2	0
DIPYRIDAMOLE	SLC29A1	Small molecule	INHIBITOR	3',5'-cyclic phosphodiesterase inhibitor	4	0
THIOPENTAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
CLONAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ZONISAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PHENACEMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PENTOBARBITAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
VOLINANSERIN	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	3	0
RILUZOLE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ERLOSAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ARTICAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MOLINDONE HYDROCHLORIDE	HTR2A	Small molecule	ANTAGONIST	Dopamine D2 receptor antagonist	4	0
OXCARBAZEPINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUINIDINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
METHARBITAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
MEPIVACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PROPOFOL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
HALOPERIDOL DECANOATE	HTR2A	Small molecule	INVERSE AGONIST	D2-like dopamine receptor inverse agonist	4	0
MEXILETINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
BENOXINATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PADSEVONIL	SV2C	Small molecule	MODULATOR	Synaptic vesicle protein modulator	3	0
DESFLURANE	GABRG2	Small molecule	OPENER	Potassium channel subfamily K member 2 opener	4	0
VOCLOSPORIN	PPP3CA	Protein	INHIBITOR	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform inhibitor	4	0
ZIPRASIDONE HYDROCHLORIDE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
ZALEPLON	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator	4	0
BUTALBITAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
COCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PROCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
LURASIDONE HYDROCHLORIDE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
PROGLUMIDE	CCKBR	Small molecule	ANTAGONIST	Cholecystokinin receptor antagonist	4	0
DARIGABAT	GABRG2	Small molecule	AGONIST	GABA-A receptor; anion channel agonist	2	0
NERISPIRDINE	KCNH2	Small molecule	BLOCKER	Voltage-gated potassium channel blocker	2	0
CLOTHIAPINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2 (5-HT2) receptor antagonist	4	0
TRIMIPRAMINE	SLC6A2	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4	0
ZIPRASIDONE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
MINAPRINE	MAOA	Small molecule	INHIBITOR	Monoamine oxidase A inhibitor	4	0
PROCAINAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ABOBOTULINUMTOXINA	SNAP25	Unknown	INHIBITOR	Synaptosomal-associated protein 25 inhibitor	4	0
TRIAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
LURASIDONE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
EPLIVANSERIN	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	3	0
TETRACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
LAMOTRIGINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
DEXFENFLURAMINE	HTR1B	Small molecule	AGONIST	Serotonin (5-HT) receptor agonist	4	0
DISOPYRAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
NEFAZODONE HYDROCHLORIDE	SLC6A2	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
RISPERIDONE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2c (5-HT2c) receptor antagonist	4	0
SB-773812	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	2	0
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CYCLOBENZAPRINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
TOCAINIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CLORAZEPATE DIPOTASSIUM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
PIMAVANSERIN TARTRATE	HTR2A	Small molecule	INVERSE AGONIST	Serotonin 2a (5-HT2a) receptor inverse agonist	4	0
ETOMIDATE	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
DROPERIDOL	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
VABICASERIN	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	2	0
EVENAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	2	0
DISOPYRAMIDE PHOSPHATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
REMIMAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
MEXILETINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
NEFAZODONE	SLC6A2	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
PHENAZOPYRIDINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ESLICARBAZEPINE ACETATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CYCLOBENZAPRINE HYDROCHLORIDE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
TRIFLUOPERAZINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
HALOPERIDOL LACTATE	HTR2A	Small molecule	INVERSE AGONIST	D2-like dopamine receptor inverse agonist	4	0
DIGOXIN	ATP1A1	Small molecule	INHIBITOR	Sodium/potassium-transporting ATPase inhibitor	4	0
CENOBAMATE	SCN2A	Small molecule	INHIBITOR	Sodium channel alpha subunit inhibitor	4	0
PRABOTULINUMTOXIN A	SNAP25	Unknown	PROTEOLYTIC ENZYME	Synaptosomal-associated protein 25 proteolytic enzyme	4	0
LIDOCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
GABAPENTIN ENACARBIL	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
CLOBAZAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
HSK-3486	GABRG2	Small molecule	AGONIST	GABA-A receptor; anion channel agonist	3	0
DRONEDARONE HYDROCHLORIDE	CACNA1D	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
TEMANOGREL	HTR2A	Small molecule	INVERSE AGONIST	Serotonin 2a (5-HT2a) receptor inverse agonist	2	0
ACETYLDIGITOXIN	ATP1A1	Small molecule	INHIBITOR	Sodium/potassium-transporting ATPase inhibitor	4	0
MOLINDONE	HTR2A	Small molecule	ANTAGONIST	Dopamine D2 receptor antagonist	4	0
RUFINAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PREGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
ETHOTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ATAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	2	0
ASENAPINE MALEATE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
HALAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
GABAPENTIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
MEPROBAMATE	GABRG2	Small molecule	AGONIST	GABA-A receptor; anion channel agonist	4	0
ISOFLURANE	KCNK10	Small molecule	OPENER	Potassium channel subfamily K member 2 opener	4	0
LIDOCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	1
QUINIDINE GLUCONATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
OXAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
QUINIDINE SULFATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
FLURAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
CLORAZEPIC ACID	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
BREXANOLONE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
NELOTANSERIN	HTR2A	Small molecule	INVERSE AGONIST	Serotonin 2a (5-HT2a) receptor inverse agonist	2	0
ACAMPROSATE	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
ASENAPINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
PRIMIDONE	SCN2A	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
DIAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
RALFINAMIDE	MAOB	Small molecule	INHIBITOR	Monoamine oxidase B inhibitor	3	0
BEPRIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
TEMAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
ESMIRTAZAPINE MALEATE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3	0
SULOCTIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
REMIMAZOLAM BESYLATE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
PIMAVANSERIN	HTR2A	Small molecule	INVERSE AGONIST	Serotonin 2a (5-HT2a) receptor inverse agonist	4	0
SEVOFLURANE	KCNK2	Small molecule	OPENER	Potassium channel subfamily K member 18 opener	4	0
INCOBOTULINUMTOXINA	SNAP25	Unknown	INHIBITOR	Synaptosomal-associated protein 25 inhibitor	4	0
TRIFLUOPERAZINE HYDROCHLORIDE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
IMAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	3	0
CLOMETHIAZOLE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
PRILOCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
LUMATEPERONE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
LORAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
CHLORPROTHIXENE	HTR2A	Small molecule	ANTAGONIST	Dopamine D2 receptor antagonist	4	0
HALOPERIDOL	HTR2A	Small molecule	INVERSE AGONIST	D2-like dopamine receptor inverse agonist	4	0
GANAXOLONE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	3	0
ADIPIPLON	GABRG2	Small molecule	PARTIAL AGONIST	GABA-A receptor; anion channel partial agonist	2	0
AMISULPRIDE	HTR1B	Small molecule	ANTAGONIST	Dopamine receptors; D2 & D3 antagonist	4	0
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUETIAPINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2c (5-HT2c) receptor antagonist	4	0
IFERANSERIN	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	3	0
PRASINEZUMAB	SNCA	Antibody	BINDING AGENT	Alpha-synuclein binding agent	2	0
TRAZODONE	HTR2A	Small molecule	INHIBITOR	Serotonin transporter inhibitor	4	0
TOPIRAMATE	CA4	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
DIGITOXIN	ATP1A1	Small molecule	INHIBITOR	Sodium/potassium-transporting ATPase inhibitor	4	0
ESMIRTAZAPINE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3	0
PHENAZOPYRIDINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MESORIDAZINE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
ZOLPIDEM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator	4	0
DRONEDARONE	CACNA1D	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PALIPERIDONE PALMITATE	HTR2A	Small molecule	ANTAGONIST	Dopamine D2 receptor antagonist	4	0
FOSPHENYTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CARBAMAZEPINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
COCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CINPANEMAB	SNCA	Antibody	INHIBITOR	Alpha-synuclein inhibitor	2	0
ZOLPIDEM TARTRATE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator	4	0
FLURAZEPAM HYDROCHLORIDE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
DAXIBOTULINUMTOXINA	SNAP25	Unknown	INHIBITOR	Synaptosomal nerve-associated protein 25 (SNAP-25) inhibitor	3	0
DESLANOSIDE	ATP1A1	Small molecule	INHIBITOR	Sodium/potassium-transporting ATPase inhibitor	4	0
OLANZAPINE PAMOATE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	4	0
PROPAFENONE	ADRB2	Small molecule	ANTAGONIST	Beta-1 adrenergic receptor antagonist	4	0
PROPARACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CLOTIAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
SARPOGRELATE	HTR2A	Small molecule	ANTAGONIST	Serotonin 2a (5-HT2a) receptor antagonist	3	0
NETAZEPIDE	CCKBR	Protein	ANTAGONIST	Cholecystokinin B receptor antagonist	2	0
CHLOROPROCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ISTAROXIME	ATP1A1	Small molecule	INHIBITOR	Sodium/potassium-transporting ATPase inhibitor	2	0
METHOXYFLURANE	GABRG2	Small molecule	AGONIST	Glycine receptor (alpha-1/beta) agonist	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-460

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs