Regulon – gbmMINER Portal

Regulon: R-3266

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
7	1.38784	1	0	Pr-8

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
4854	ENSG00000074181	NOTCH3	Q9UM47
11078	ENSG00000100106	TRIOBP	Q9H2D6
5159	ENSG00000113721	PDGFRB	P09619
7837	ENSG00000130508	PXDN	Q92626
8291	ENSG00000135636	DYSF	O75923
2615	ENSG00000137507	LRRC32	Q14392
4782	ENSG00000141905	NFIC	P08651

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
PAZOPANIB	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	1
MIDOSTAURIN	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	0
CRENOLANIB	PDGFRB	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	2
TIVOZANIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	2
SUNITINIB	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
SORAFENIB TOSYLATE	PDGFRB	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
TELATINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0
SORAFENIB	FLT3	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
PAZOPANIB HYDROCHLORIDE	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	0
VATALANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	1
TANDUTINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	2	2
NINTEDANIB ESYLATE	FGFR3	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	4	0
FORETINIB	TEK	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
IMATINIB MESYLATE	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
SUNITINIB MALATE	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
XL-999	PDGFRB	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	2	0
X-82	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
DOVITINIB	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	1
BECAPLERMIN	PDGFRB	Protein	AGONIST	Platelet-derived growth factor receptor agonist	4	0
SU-014813	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
ILORASERTIB	PDGFRB	Small molecule	INHIBITOR	Serine/threonine-protein kinase Aurora inhibitor	2	0
ANLOTINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 3 inhibitor	3	2
IMATINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
JI-101	PDGFRB	Small molecule	INHIBITOR	Ephrin type-B receptor 4 inhibitor	2	0
TAREXTUMAB	NOTCH3	Antibody	INHIBITOR	Neurogenic locus notch homolog protein 3 inhibitor	1	0
XL-820	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0
NINTEDANIB	FGFR3	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	4	2
MASITINIB	KIT	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	3	0
TG100-801	EPHB4	Small molecule	INHIBITOR	SRC inhibitor	2	0
MOTESANIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor RET inhibitor	3	0
ORANTINIB	PDGFRB	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	3	0
RG-1530	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	1	0
QUIZARTINIB	PDGFRB	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	0
RINUCUMAB	PDGFRB	Antibody	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	2	0
TAK-593	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	1	0
LINIFANIB	CSF1R	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	0
CM-082	FLT3	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	3	0
CEDIRANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	3
REGORAFENIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	4	2
FAMITINIB	KDR	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	0
TIVOZANIB HYDROCHLORIDE	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	0
ENMD-981693	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3266

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs