Regulon – gbmMINER Portal

Regulon: R-2052

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
25	-1.92156	1	0	Pr-62

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
2065	ENSG00000065361	ERBB3	P21860
1400	ENSG00000072832	CRMP1	Q14194
1641	ENSG00000077279	DCX	E7EU50
5027	ENSG00000089041	P2RX7	Q99572
27324	ENSG00000103460	TOX3	O15405
6505	ENSG00000106688	SLC1A1	P43005
22858	ENSG00000112144	ICK	Q9UPZ9
1627	ENSG00000113758	DBN1	Q16643
50512	ENSG00000114631	PODXL2	Q9NZ53
23046	ENSG00000116852	KIF21B	O75037
6659	ENSG00000124766	SOX4	Q06945
5911	ENSG00000125249	RAP2A	P10114
6328	ENSG00000153253	SCN3A	A0A590UJW3
2047	ENSG00000154928	EPHB1	P54762
9844	ENSG00000155849	ELMO1	Q92556
3516	ENSG00000168214	RBPJ	Q06330
90362	ENSG00000169122	FAM110B	Q8TC76
9788	ENSG00000170873	MTSS1	O43312
55636	ENSG00000171316	CHD7	Q9P2D1
6664	ENSG00000176887	SOX11	P35716
6304	ENSG00000182568	SATB1	Q01826
7267	ENSG00000182670	TTC3	P53804
3066	ENSG00000196591	HDAC2	Q92769
3823	ENSG00000205810	KLRC3	Q07444
4661	ENSG00000276876	MYT1	Q01538

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
CE-224535	P2RX7	Small molecule	ANTAGONIST	P2X purinoceptor 7 antagonist	2	0
POZIOTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor inhibitor	2	0
MM-111	ERBB2	Unknown	INHIBITOR	ErbB-2/ErbB-3 heterodimer inhibitor	2	0
ROPIVACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MORICIZINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CUDC-101	HDAC1	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
PHENYTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUINIDINE POLYGALACTURONATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
FOSPHENYTOIN SODIUM	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CHLOROPROCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
DULIGOTUZUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	2	0
ENCAINIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ZENOCUTUZUMAB	ERBB2	Antibody	INHIBITOR	ErbB-2/ErbB-3 heterodimer inhibitor	2	0
GSK1482160	P2RX7	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	P2X purinoceptor 7 negative allosteric modulator	1	0
ESLICARBAZEPINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PROCAINAMIDE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MEPHENYTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
SAPITINIB	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	2	0
AMG-888	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	2	0
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ELGEMTUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	1	0
ISTIRATUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	2	0
MOCETINOSTAT	HDAC2	Small molecule	INHIBITOR	Histone deacetylase 11 inhibitor	2	0
PROCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PROPAFENONE HYDROCHLORIDE	ADRB2	Small molecule	ANTAGONIST	Beta-1 adrenergic receptor antagonist	4	0
ROPIVACAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
KBP5209	ERBB2	Unknown	INHIBITOR	Epidermal growth factor receptor inhibitor	1	0
TARLOXOTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor inhibitor	2	0
AV-203	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	1	0
ABEXINOSTAT	HDAC1	Small molecule	INHIBITOR	Histone deacetylase inhibitor	3	0
ZONISAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PHENACEMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
RILUZOLE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ERLOSAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ARTICAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
OXCARBAZEPINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUINIDINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
VANDETANIB	EPHA2	Small molecule	INHIBITOR	Tyrosine-protein kinase SRC inhibitor	4	2
PATRITUMAB DERUXTECAN	TOP1	Antibody	INHIBITOR	DNA topoisomerase I inhibitor	2	0
MEPIVACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MEXILETINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
BENOXINATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
COCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PROCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
NERISPIRDINE	KCNH2	Small molecule	BLOCKER	Voltage-gated potassium channel blocker	2	0
PROCAINAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
TETRACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
LAMOTRIGINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
DISOPYRAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ENTINOSTAT	HDAC1	Small molecule	INHIBITOR	Histone deacetylase inhibitor	3	0
VORINOSTAT	HDAC2	Small molecule	INHIBITOR	Histone deacetylase 6 inhibitor	4	2
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
TOCAINIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
EVENAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	2	0
DISOPYRAMIDE PHOSPHATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ROMIDEPSIN	HDAC1	Protein	INHIBITOR	Histone deacetylase inhibitor	4	1
TACEDINALINE	HDAC1	Small molecule	INHIBITOR	Histone deacetylase inhibitor	3	0
MEXILETINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PHENAZOPYRIDINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ESLICARBAZEPINE ACETATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
MM-121	ERBB3	Antibody	ANTAGONIST	Receptor tyrosine-protein kinase erbB-3 antagonist	2	0
CENOBAMATE	SCN2A	Small molecule	INHIBITOR	Sodium channel alpha subunit inhibitor	4	0
LIDOCAINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
DRONEDARONE HYDROCHLORIDE	CACNA1D	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
RUFINAMIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
ETHOTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PATRITUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	3	0
SERIBANTUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	2	0
FIMEPINOSTAT	PIK3CD	Small molecule	INHIBITOR	PI3-kinase p110-alpha subunit inhibitor	2	0
LIDOCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	1
QUINIDINE GLUCONATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
QUINIDINE SULFATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PRIMIDONE	SCN2A	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4	0
RALFINAMIDE	MAOB	Small molecule	INHIBITOR	Monoamine oxidase B inhibitor	3	0
PRILOCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
PANOBINOSTAT LACTATE	HDAC1	Small molecule	INHIBITOR	Histone deacetylase inhibitor	4	0
CDX-3379	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	2	0
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
TOPIRAMATE	CA4	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
BELINOSTAT	HDAC1	Small molecule	INHIBITOR	Histone deacetylase inhibitor	4	2
PANOBINOSTAT	HDAC1	Small molecule	INHIBITOR	Histone deacetylase inhibitor	4	2
LUMRETUZUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	1	0
PHENAZOPYRIDINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
DRONEDARONE	CACNA1D	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
FOSPHENYTOIN	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CARBAMAZEPINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
COCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
AZD9056	P2RX7	Small molecule	ANTAGONIST	P2X purinoceptor 7 antagonist	2	0
PROPAFENONE	ADRB2	Small molecule	ANTAGONIST	Beta-1 adrenergic receptor antagonist	4	0
PROPARACAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
JNJ-54175446	P2RX7	Small molecule	ANTAGONIST	P2X purinoceptor 7 antagonist	2	0
CHLOROPROCAINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2052

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs