Regulon – gbmMINER Portal

Regulon: R-1303

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
22	1.57856	1	0	Pr-143

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
1495	ENSG00000044115	CTNNA1	E5RGS1
9689	ENSG00000082153	BZW1	Q7L1Q6
3655	ENSG00000091409	ITGA6	P23229
5216	ENSG00000108518	PFN1	P07737
3312	ENSG00000109971	HSPA8	A8K7Q2
10114	ENSG00000110422	HIPK3	Q9H422
10728	ENSG00000110958	PTGES3	Q15185
2030	ENSG00000112759	SLC29A1	Q99808
55825	ENSG00000115425	PECR	Q9BY49
5052	ENSG00000117450	PRDX1	Q06830
3936	ENSG00000136167	LCP1	P13796
7099	ENSG00000136869	TLR4	O00206
79634	ENSG00000144306	SCRN3	Q0VDG4
9180	ENSG00000145623	OSMR	Q99650
5051	ENSG00000158006	PAFAH2	Q99487
1973	ENSG00000161960	EIF4A1	P60842
6565	ENSG00000163406	SLC15A2	Q16348
25932	ENSG00000169504	CLIC4	Q9Y696
4973	ENSG00000173391	OLR1	A0A024RAU0
8073	ENSG00000184007	PTP4A2	Q12974
2760	ENSG00000196743	GM2A	P17900
4067	ENSG00000254087	LYN	P07948

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
DIPYRIDAMOLE	SLC29A1	Small molecule	INHIBITOR	3',5'-cyclic phosphodiesterase inhibitor	4	0
FORIGERIMOD	HSPA8	Protein	INHIBITOR	Heat shock cognate 71 kDa protein inhibitor	3	0
BOSUTINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	2
BAFETINIB	LYN	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	2	0
ILORASERTIB	PDGFRB	Small molecule	INHIBITOR	Serine/threonine-protein kinase Aurora inhibitor	2	0
JNJ-26483327	ERBB2	Small molecule	INHIBITOR	Tyrosine-protein kinase FYN inhibitor	1	0
RESATORVID	TLR4	Small molecule	INHIBITOR	Toll-like receptor 4 inhibitor	3	0
XL-228	ABL1	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	1	0
FORIGERIMOD ACETATE	HSPA8	Protein	INHIBITOR	Heat shock cognate 71 kDa protein inhibitor	3	0
TOLIMIDONE	LYN	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Tyrosine-protein kinase Lyn positive allosteric modulator	2	0
ERITORAN TETRASODIUM	TLR4	Small molecule	ANTAGONIST	Toll-like receptor 4/MD-2 antagonist	3	0
TG100-801	EPHB4	Small molecule	INHIBITOR	SRC inhibitor	2	0
ERITORAN	TLR4	Small molecule	ANTAGONIST	Toll-like receptor 4/MD-2 antagonist	3	0
ENMD-981693	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1303

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs