Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
POU3F2 - POU class 3 homeobox 2
Function
Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5454 | ENSG00000184486 | POU3F2 | P20265 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1166 | Pr-39 | 1 | 1 | 12 |
| R-1185 | Pr-177 | 1 | 1 | 14 |
| R-121 | Pr-39 | 1 | 1 | 9 |
| R-1225 | Pr-39 | 1 | 1 | 24 |
| R-1253 | Pr-39 | 1 | 1 | 28 |
| R-1470 | Pr-39 | 1 | 1 | 5 |
| R-1571 | Pr-39 | 1 | 1 | 14 |
| R-1597 | Pr-39 | 1 | 1 | 9 |
| R-1707 | Pr-39 | 1 | 1 | 14 |
| R-1790 | Pr-39 | 1 | 1 | 6 |
| R-2690 | Pr-39 | 1 | 1 | 13 |
| R-3683 | Pr-39 | 1 | 1 | 20 |
| R-426 | Pr-39 | 1 | 1 | 20 |
| R-556 | Pr-39 | 1 | 1 | 6 |
| R-649 | Pr-6 | 1 | 1 | 13 |
| R-702 | Pr-39 | 1 | 1 | 4 |
| R-825 | Pr-39 | 1 | 1 | 9 |
| R-873 | Pr-39 | 1 | 1 | 6 |
| R-892 | Pr-177 | 1 | 1 | 2 |
| R-974 | Pr-39 | 1 | 1 | 5 |