Regulon

Regulon: R-622

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
32	3.0768	1	12	Pr-131

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
330	ENSG00000023445	BIRC3	Q13489
9497	ENSG00000033867	SLC4A7	Q9Y6M7
6515	ENSG00000059804	SLC2A3	P11169
2009	ENSG00000066629	EML1	O00423
26002	ENSG00000079931	MOXD1	Q6UVY6
23645	ENSG00000087074	PPP1R15A	O75807
5634	ENSG00000101911	PRPS2	P11908
4233	ENSG00000105976	MET	A0A024R728
1845	ENSG00000108861	DUSP3	P51452
64065	ENSG00000112378	PERP	Q96FX8
10802	ENSG00000113615	SEC24A	O95486
2632	ENSG00000114480	GBE1	Q04446
10096	ENSG00000115091	ACTR3	P61158
23169	ENSG00000116704	SLC35D1	Q9NTN3
8987	ENSG00000118804	STBD1	O95210
1948	ENSG00000125266	EFNB2	P52799
59269	ENSG00000127124	HIVEP3	Q5T1R4
9590	ENSG00000131016	AKAP12	Q02952
8572	ENSG00000131435	PDLIM4	P50479
3939	ENSG00000134333	LDHA	P00338
2100	ENSG00000140009	ESR2	Q7LCB3
29982	ENSG00000148572	NRBF2	Q96F24
55002	ENSG00000150403	TMCO3	A0A024RE09
5784	ENSG00000152104	PTPN14	Q15678
5922	ENSG00000155903	RASA2	D6RBA9
5130	ENSG00000161217	PCYT1A	P49585
10116	ENSG00000169018	FEM1B	Q9UK73
9197	ENSG00000169359	SLC33A1	O00400
90411	ENSG00000180398	MCFD2	Q8NI22
8204	ENSG00000180530	NRIP1	P48552
64746	ENSG00000182827	ACBD3	Q9H3P7
3690	ENSG00000259207	ITGB3	P05106

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ESTROGENS, ESTERIFIED	ESR2	Small molecule	AGONIST	Estrogen receptor agonist	4	0
SAVOLITINIB	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	3	0
TELISOTUZUMAB VEDOTIN	MET	Antibody	BINDING AGENT	Hepatocyte growth factor receptor binding agent	3	0
ATN-161	ITGB3	Protein	ANTAGONIST	Integrin alpha-5/beta-1 antagonist	2	0
RALOXIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor beta modulator	4	0
PRINABEREL	ESR2	Small molecule	AGONIST	Estrogen receptor beta agonist	2	0
LASOFOXIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
AMUVATINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	2	0
BAZEDOXIFENE ACETATE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
CHLOROTRIANISENE	ESR2	Small molecule	MODULATOR	Estrogen receptor beta modulator	4	0
ESTRIOL	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
BIRINAPANT	BIRC3	Small molecule	INHIBITOR	cIAP1/cIAP2 inhibitor	2	0
ACOLBIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	3	0
CABOZANTINIB	MET	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	2
ALTIRATINIB	TEK	Small molecule	INHIBITOR	Neurotrophic tyrosine kinase receptor inhibitor	1	0
SGX-523	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
TEREVALEFIM	MET	Small molecule	AGONIST	Hepatocyte growth factor receptor agonist	3	0
SYNTHETIC CONJUGATED ESTROGENS, B	ESR2	Small molecule	AGONIST	Estrogen receptor agonist	4	0
OSPEMIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
TEPOTINIB HYDROCHLORIDE	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	0
TOREMIFENE CITRATE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
FORETINIB	TEK	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
RALOXIFENE HYDROCHLORIDE	ESR2	Small molecule	MODULATOR	Estrogen receptor beta modulator	4	0
ONARTUZUMAB	MET	Antibody	ANTAGONIST	Hepatocyte growth factor receptor antagonist	3	2
SAR-125844	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
ERTEBEREL	ESR2	Small molecule	AGONIST	Estrogen receptor beta agonist	2	0
AMG-208	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
FULVESTRANT	ESR2	Small molecule	ANTAGONIST	Estrogen receptor antagonist	4	0
CILENGITIDE	ITGAV	Protein	ANTAGONIST	Integrin alpha-V/beta-3 antagonist	3	3
TIROFIBAN HYDROCHLORIDE	ITGB3	Small molecule	INHIBITOR	Integrin alpha-IIb/beta-3 inhibitor	4	0
ESTROGENS, CONJUGATED SYNTHETIC A	ESR2	Small molecule	AGONIST	Estrogen receptor agonist	4	0
ESTROGENS, CONJUGATED	ESR2	Small molecule	AGONIST	Estrogen receptor agonist	4	0
MK-8033	MET	Small molecule	INHIBITOR	Macrophage-stimulating protein receptor inhibitor	1	0
FISPEMIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	2	0
AMG-337	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
ABCIXIMAB	ITGB3	Antibody	INHIBITOR	Integrin alpha-V/beta-3 inhibitor	4	0
CAPMATINIB HYDROCHLORIDE	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	0
AMIVANTAMAB	MET	Antibody	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	0
AFIMOXIFENE	ESRRG	Small molecule	MODULATOR	Estrogen receptor modulator	3	0
MK-2461	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
MERESTINIB	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
DIETHYLSTILBESTROL DIPHOSPHATE	ESR2	Small molecule	AGONIST	Estrogen receptor agonist	4	0
BMS-777607	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
BAZEDOXIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
CAPMATINIB	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	1
ETARACIZUMAB	ITGB3	Antibody	ANTAGONIST	Integrin alpha-V/beta-3 antagonist	2	0
JNJ-38877605	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
GLESATINIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
INTETUMUMAB	ITGAV	Antibody	ANTAGONIST	Integrin alpha-V/beta-3 antagonist	2	0
BMS-817378	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
CABOZANTINIB S-MALATE	MET	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	2
MF101	ESR2	Small molecule	AGONIST	Estrogen receptor beta agonist	3	0
AUS-131	ESR2	Small molecule	AGONIST	Estrogen receptor beta agonist	2	0
CRIZOTINIB	ALK	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	1
TOREMIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	4	0
EMD-1204831	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
TIVANTINIB	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	3	0
ESTRAMUSTINE PHOSPHATE	ESR2	Small molecule	MODULATOR	Estrogen receptor beta modulator	4	0
NEDOSIRAN SODIUM	LDHA	Oligonucleotide	RNAI INHIBITOR	L-lactate dehydrogenase A chain mRNA RNAi inhibitor	3	0
TELISOTUZUMAB	MET	Antibody	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
ESTETROL	ESR2	Small molecule	AGONIST	Estrogen receptor agonist	4	0
TEPOTINIB	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	0
EMIBETUZUMAB	MET	Antibody	INHIBITOR	Hepatocyte growth factor receptor inhibitor	2	0
BPI-9016	AXL	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor UFO inhibitor	1	0
ESTRAMUSTINE PHOSPHATE SODIUM	ESR2	Small molecule	MODULATOR	Estrogen receptor beta modulator	4	0
PF-04217903	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
ARZOXIFENE	ESR2	Small molecule	MODULATOR	Estrogen receptor modulator	3	0
EPTIFIBATIDE	ITGB3	Protein	INHIBITOR	Integrin alpha-IIb/beta-3 inhibitor	4	0
ABITUZUMAB	ITGAV	Antibody	INHIBITOR	Integrin alpha-V/beta-5 inhibitor	2	0
GOLVATINIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0
TIROFIBAN	ITGB3	Small molecule	INHIBITOR	Integrin alpha-IIb/beta-3 inhibitor	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-622

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01812	TMPRSS15	up-regulates	BCL6	activates	R-622	23	6	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-03255	HRNR	down-regulates	BCL6	activates	R-622	23	2	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-08976	GPR132	up-regulates	BCL6	activates	R-622	23	5	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-11623	CHSY3	down-regulates	BCL6	activates	R-622	23	2	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-12284	GPR98	down-regulates	BCL6	activates	R-622	23	9	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-14973	XK	down-regulates	BCL6	activates	R-622	23	4	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-16558	RBM19	down-regulates	BCL6	activates	R-622	23	7	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-17991	PRPF40B	down-regulates	BCL6	activates	R-622	23	11	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-22099	OR2T34	down-regulates	BCL6	activates	R-622	23	3	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-24483	SEMA3C	down-regulates	BCL6	activates	R-622	23	12	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-25953	C10orf12	down-regulates	BCL6	activates	R-622	23	3	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN
CMF-27024	DNAH5	up-regulates	BCL6	activates	R-622	23	4	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN

Regulon: R-622

Regulon Summary

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Causal Mechanistic Flows for Regulon R-622

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