Regulon

Regulon: R-597

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
291.98554130Pr-108Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
5798 ENSG00000054356 PTPRN Q16849
537 ENSG00000071553 ATP6AP1 Q15904
5566 ENSG00000072062 PRKACA P17612
9891 ENSG00000074590 NUAK1 O60285
23136 ENSG00000082397 EPB41L3 J3QS55
610 ENSG00000099822 HCN2 Q9UL51
1917 ENSG00000101210 EEF1A2 Q05639
6324 ENSG00000105711 SCN1B Q07699
30850 ENSG00000109089 CDR2L Q86X02
55700 ENSG00000116871 MAP7D1 Q3KQU3
6253 ENSG00000125744 RTN2 O75298
60484 ENSG00000132702 HAPLN2 Q9GZV7
23148 ENSG00000136274 NACAD O15069
274 ENSG00000136717 BIN1 O00499
7280 ENSG00000137267 TUBB2A Q13885
526 ENSG00000147416 ATP6V1B2 P21281
10435 ENSG00000149798 CDC42EP2 O14613
7070 ENSG00000154096 THY1 P04216
9715 ENSG00000159784 FAM131B Q86XD5
57863 ENSG00000162706 CADM3 Q8N126
55323 ENSG00000166173 LARP6 Q9BRS8
10501 ENSG00000167680 SEMA6B Q9H3T3
3777 ENSG00000171303 KCNK3 O14649
253982 ENSG00000174939 ASPHD1 Q5U4P2
79605 ENSG00000177614 PGBD5 Q8N414
54913 ENSG00000178718 RPP25 Q9BUL9
23396 ENSG00000186111 PIP5K1C O60331
4155 ENSG00000197971 MBP P02686
89927 ENSG00000278823 C16orf45 Q96MC5

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
ERIBULIN MESYLATETUBB1Small moleculeINHIBITORTubulin inhibitor40
SAGOPILONETUBB1Small moleculeSTABILISERTubulin stabiliser22
AGS-16C3FTUBB1UnknownDISRUPTING AGENTTubulin disrupting agent20
TELISOTUZUMAB VEDOTINMETAntibodyBINDING AGENTHepatocyte growth factor receptor binding agent30
DOCETAXELTUBB1Small moleculeINHIBITORTubulin inhibitor40
FOSBRETABULIN DISODIUMTUBB1Small moleculeINHIBITORTubulin inhibitor20
VINCRISTINETUBB1Small moleculeINHIBITORTubulin inhibitor43
VINFLUNINETUBB1Small moleculeINHIBITORTubulin inhibitor40
LEXIBULINTUBB1Small moleculeINHIBITORTubulin inhibitor21
VINCRISTINE SULFATETUBB1Small moleculeINHIBITORTubulin inhibitor43
TRASTUZUMAB EMTANSINEERBB2AntibodyINHIBITORTubulin inhibitor40
ENFORTUMAB VEDOTINTUBB1AntibodyBINDING AGENTNectin-4 binding agent40
VINORELBINE TARTRATETUBB1Small moleculeINHIBITORTubulin inhibitor40
LIFASTUZUMAB VEDOTINTUBB1AntibodyBINDING AGENTSodium-dependent phosphate transport protein 2B binding agent20
KOS-1584TUBB1Small moleculeSTABILISERTubulin stabiliser20
PRALUZATAMAB RAVTANSINEALCAMAntibodyINHIBITORTubulin inhibitor20
LADIRATUZUMAB VEDOTINTUBB1AntibodyINHIBITORTubulin inhibitor20
PACLITAXELTUBB1Small moleculeINHIBITORTubulin inhibitor41
CROLIBULINTUBB1Small moleculeINHIBITORTubulin inhibitor10
PACLITAXEL POLIGLUMEXTUBB1Small moleculeSTABILISERTubulin stabiliser30
PATUPILONETUBB1Small moleculeSTABILISERTubulin stabiliser31
ASG-5METUBB1AntibodyINHIBITORTubulin inhibitor10
ANG1005LRP1ProteinBINDING AGENTProlow-density lipoprotein receptor-related protein 1 binding agent32
PINATUZUMAB VEDOTINTUBB1AntibodyINHIBITORTubulin inhibitor10
VERUBULINTUBB1Small moleculeDISRUPTING AGENTTubulin disrupting agent22
VINBLASTINE SULFATETUBB1Small moleculeINHIBITORTubulin inhibitor40
VINORELBINETUBB1Small moleculeINHIBITORTubulin inhibitor42
DESFLURANEGABRG2Small moleculeOPENERPotassium channel subfamily K member 2 opener40
DAVUNETIDETUBB1ProteinSTABILISERTubulin stabiliser20
BELANTAMAB MAFODOTINTUBB1AntibodyBINDING AGENTTumor necrosis factor receptor superfamily member 17 binding agent40
FOSBRETABULINTUBB1Small moleculeDISRUPTING AGENTTubulin disrupting agent30
ABT-751TUBB1Small moleculeINHIBITORTubulin beta inhibitor20
MIRVETUXIMAB SORAVTANSINEFOLR1AntibodyINHIBITORTubulin inhibitor30
IXABEPILONETUBB1Small moleculeINHIBITORTubulin inhibitor41
POLATUZUMAB VEDOTINTUBB1AntibodyBINDING AGENTB-cell antigen receptor complex-associated protein beta chain binding agent40
T-900607TUBB1Small moleculeDISRUPTING AGENTTubulin disrupting agent20
PLITIDEPSINEEF1A2Small moleculeINHIBITORElongation factor 1-alpha 2 inhibitor30
APRUTUMAB IXADOTINTUBB1AntibodyBINDING AGENTFibroblast growth factor receptor 2 binding agent10
PLINABULINTUBB1Small moleculeINHIBITORTubulin inhibitor30
TISOTUMAB VEDOTINF3AntibodyBINDING AGENTCoagulation factor III binding agent40
DOLASTATIN-10TUBB1Small moleculeINHIBITORTubulin inhibitor20
FOSBRETABULIN TROMETHAMINETUBB1Small moleculeDISRUPTING AGENTTubulin disrupting agent20
SAR-408701TUBB1UnknownBINDING AGENTCarcinoembryonic antigen-related cell adhesion molecule 5 binding agent30
CABAZITAXELTUBB1Small moleculeINHIBITORTubulin inhibitor42
PACLITAXEL DOCOSAHEXAENOIC ACIDTUBB1Small moleculeSTABILISERTubulin stabiliser30
ISOFLURANEKCNK10Small moleculeOPENERPotassium channel subfamily K member 2 opener40
ERIBULINTUBB1Small moleculeINHIBITORTubulin inhibitor40
BMS-275183TUBB1Small moleculeSTABILISERTubulin stabiliser20
INDUSATUMAB VEDOTINTUBB1AntibodyBINDING AGENTHeat-stable enterotoxin receptor binding agent20
GLEMBATUMUMAB VEDOTINTUBB1AntibodyBINDING AGENTTransmembrane glycoprotein NMB binding agent20
COLCHICINETUBB1Small moleculeINHIBITORTubulin inhibitor40
VANDORTUZUMAB VEDOTINSTEAP1AntibodyINHIBITORTubulin inhibitor10
VINBLASTINETUBB1Small moleculeINHIBITORTubulin inhibitor40
BRENTUXIMAB VEDOTINTNFRSF8AntibodyINHIBITORTubulin inhibitor40
SEVOFLURANEKCNK2Small moleculeOPENERPotassium channel subfamily K member 18 opener40
EPOTHILONE DTUBB1Small moleculeSTABILISERTubulin stabiliser20
SOFITUZUMAB VEDOTINTUBB1AntibodyBINDING AGENTMucin-16 binding agent10
INDIBULINTUBB1Small moleculeINHIBITORTubulin inhibitor10
AZINTUXIZUMAB VEDOTINTUBB1AntibodyINHIBITORTubulin inhibitor10
DOXAPRAMKCNK3Small moleculeBLOCKERPotassium channel subfamily K member 9 blocker40
DOXAPRAM HYDROCHLORIDEKCNK3Small moleculeBLOCKERPotassium channel subfamily K member 9 blocker40
LAROTAXELTUBB1Small moleculeSTABILISERTubulin stabiliser30
RG-7841TUBB1UnknownINHIBITORTubulin inhibitor10
GSK-690693PRKACBSmall moleculeINHIBITORProtein kinase C (PKC) inhibitor10
LORVOTUZUMAB MERTANSINENCAM1AntibodyINHIBITORTubulin inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-597

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-05051ITPR3down-regulatesMAZactivatesR-597252Drugs (65)
CMF-33905TLR2down-regulateshsa-mir-500repressesR-59721Drugs (65)
CMF-34174TCHHup-regulateshsa-mir-339repressesR-59711Drugs (65)
CMF-34175TCHHup-regulateshsa-mir-500repressesR-59721Drugs (65)
CMF-35163FAT3down-regulateshsa-mir-500repressesR-59721Drugs (65)
CMF-35164FAT3down-regulateshsa-mir-30a-3prepressesR-59711Drugs (65)
CMF-35945MAGdown-regulateshsa-mir-500repressesR-59721Drugs (65)
CMF-36505ESR2down-regulateshsa-mir-502repressesR-59711Drugs (65)
CMF-36655RETdown-regulateshsa-mir-501repressesR-59711Drugs (65)
CMF-37724CD1Ddown-regulateshsa-mir-615repressesR-59711Drugs (65)
CMF-37750GPR141down-regulateshsa-mir-502repressesR-59711Drugs (65)
CMF-37756ELSPBP1down-regulateshsa-mir-500repressesR-59721Drugs (65)
CMF-37757ELSPBP1down-regulateshsa-mir-501repressesR-59711Drugs (65)
CMF-37910GABRA4down-regulateshsa-mir-615repressesR-59711Drugs (65)
CMF-38041PTENdown-regulateshsa-mir-502repressesR-59711Drugs (65)
CMF-38042PTENdown-regulateshsa-mir-615repressesR-59711Drugs (65)
CMF-38606ADAMTS2down-regulateshsa-mir-500repressesR-59721Drugs (65)
CMF-38657ATAD2up-regulateshsa-mir-502repressesR-59711Drugs (65)
CMF-38892CNTNAP3up-regulateshsa-mir-195repressesR-59711Drugs (65)
CMF-39051NWD1up-regulateshsa-mir-195repressesR-59711Drugs (65)
CMF-39317SLFN13down-regulateshsa-mir-615repressesR-59711Drugs (65)
CMF-41187NBPF9up-regulateshsa-mir-339repressesR-59711Drugs (65)
CMF-41932FLT3up-regulateshsa-mir-195repressesR-59711Drugs (65)
CMF-42115SLITRK2up-regulateshsa-mir-195repressesR-59711Drugs (65)
CMF-42134EGFRup-regulateshsa-mir-195repressesR-59711Drugs (65)
CMF-42480C21orf29down-regulateshsa-mir-502repressesR-59711Drugs (65)
CMF-42697ACSM4down-regulateshsa-mir-502repressesR-59711Drugs (65)
CMF-42698ACSM4down-regulateshsa-mir-501repressesR-59711Drugs (65)
CMF-42794AQP10down-regulateshsa-mir-501repressesR-59711Drugs (65)
CMF-42863OR2T3up-regulateshsa-mir-30a-3prepressesR-59711Drugs (65)