Regulon

Regulon: R-445

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
122.54552115Pr-0Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
9168 ENSG00000034510 TMSB10 P63313
966 ENSG00000085063 CD59 P13987
27286 ENSG00000102359 SRPX2 O60687
8717 ENSG00000102871 TRADD Q15628
2184 ENSG00000103876 FAH P16930
4179 ENSG00000117335 CD46 P15529
3601 ENSG00000134470 IL15RA K9N1J3
4060 ENSG00000139329 LUM P51884
3688 ENSG00000150093 ITGB1 P05556
831 ENSG00000153113 CAST P20810
2720 ENSG00000170266 GLB1 F8WEN1
3588 ENSG00000243646 IL10RB Q08334

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
ATN-161ITGB3ProteinANTAGONISTIntegrin alpha-5/beta-1 antagonist20
NATALIZUMABITGA4AntibodyINHIBITORIntegrin alpha-4/beta-1 inhibitor40
FIRATEGRASTITGB1Small moleculeANTAGONISTIntegrin alpha-4/beta-1 antagonist20
VOLOCIXIMABITGB1AntibodyANTAGONISTIntegrin alpha-5/beta-1 antagonist30
RECOMBINANT HUMAN INTERLEUKIN-15IL2RBUnknownAGONISTInterleukin-15 receptor agonist20
PEGINTERFERON LAMBDA-1AIL10RBProteinAGONISTInterferon lambda receptor agonist30
ABITUZUMABITGAVAntibodyINHIBITORIntegrin alpha-V/beta-5 inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-445

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-02805DHX30down-regulatesTCF7L1repressesR-44592Drugs (7)
CMF-04353RBPJLdown-regulatesTCF7L1repressesR-44592Drugs (7)
CMF-05786ADAMTS19up-regulatesTCF7L1repressesR-44594Drugs (7)
CMF-07173ATRXup-regulatesTCF7L1repressesR-44596Drugs (7)
CMF-09060DLG5up-regulatesTCF7L1repressesR-44591Drugs (7)
CMF-15164YEATS2up-regulatesTCF7L1repressesR-44594Drugs (7)
CMF-15566TAS2R41down-regulatesTCF7L1repressesR-44592Drugs (7)
CMF-16533OR9G4down-regulatesTCF7L1repressesR-44592Drugs (7)
CMF-20159TDRD9down-regulatesTCF7L1repressesR-44594Drugs (7)
CMF-22987IDH1up-regulatesTCF7L1repressesR-44596Drugs (7)
CMF-24116TP53up-regulatesTCF7L1repressesR-44596Drugs (7)
CMF-25109IQSEC3up-regulatesTCF7L1repressesR-44593Drugs (7)
CMF-25742TMC1up-regulatesTCF7L1repressesR-44591Drugs (7)
CMF-26612NAALADL1down-regulatesTCF7L1repressesR-44596Drugs (7)
CMF-29737ESRRBdown-regulatesTCF7L1repressesR-44593Drugs (7)