Regulon

Regulon: R-397

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
142.676151107Pr-4Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
1992 ENSG00000021355 SERPINB1 P30740
55843 ENSG00000075884 ARHGAP15 Q53QZ3
7421 ENSG00000111424 VDR F1D8P8
59342 ENSG00000121064 SCPEP1 I3L2N6
10095 ENSG00000130429 ARPC1B O15143
58472 ENSG00000137767 SQRDL Q9Y6N5
9056 ENSG00000155465 SLC7A7 Q9UM01
5603 ENSG00000156711 MAPK13 A0A024RD04
6282 ENSG00000163191 S100A11 P31949
1508 ENSG00000164733 CTSB E9PSG5
399 ENSG00000168421 RHOH Q15669
64581 ENSG00000172243 CLEC7A Q9BXN2
837 ENSG00000196954 CASP4 P49662
10437 ENSG00000216490 IFI30 P13284

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
CALCIFEDIOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
BECOCALCIDIOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
PARICALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
INECALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
ERGOCALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist40
CHOLECALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist41
DOXERCALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist40
CALCITRIOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
ELDECALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
CALCIPOTRIENEVDRSmall moleculeAGONISTVitamin D receptor agonist40
EMRICASANCASP4Small moleculeINHIBITORCaspase inhibitor20
SEOCALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
PEFCALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
LUNACALCIPOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
DP001VDRSmall moleculeAGONISTVitamin D receptor agonist20
ALFACALCIDOLVDRSmall moleculeAGONISTVitamin D receptor agonist40

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-397

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00402ZNF99up-regulatesIRF8activatesR-397182Drugs (16)
CMF-04308RBPJLup-regulatesIRF8activatesR-397186Drugs (16)
CMF-04371LILRB1up-regulatesIRF8activatesR-397181Drugs (16)
CMF-07593AHNAK2down-regulatesIRF8activatesR-397184Drugs (16)
CMF-11440CYP4F22up-regulatesIRF8activatesR-397187Drugs (16)
CMF-13855ADAMTS8down-regulatesIRF8activatesR-397184Drugs (16)
CMF-14767SLC5A12up-regulatesIRF8activatesR-397184Drugs (16)
CMF-15182FAM110Bdown-regulatesIRF8activatesR-397181Drugs (16)
CMF-15228OR51F1down-regulatesIRF8activatesR-397188Drugs (16)
CMF-15868ZNF845down-regulatesIRF8activatesR-397184Drugs (16)
CMF-19672RPSAP58up-regulatesIRF8activatesR-397185Drugs (16)
CMF-28743SYN3down-regulatesIRF8activatesR-397184Drugs (16)
CMF-29705ESRRBup-regulatesIRF8activatesR-397184Drugs (16)
CMF-30271RAB3GAP2up-regulatesIRF8activatesR-397183Drugs (16)
CMF-31185LRFN2down-regulatesIRF8activatesR-397184Drugs (16)
CMF-33957MCM6down-regulateshsa-mir-139repressesR-3975834Drugs (16)
CMF-34001MCM6down-regulateshsa-mir-129repressesR-39715576Drugs (16)
CMF-34067ZNF814up-regulateshsa-mir-129repressesR-3971558Drugs (16)
CMF-34092TMEM146down-regulateshsa-mir-454-3prepressesR-3973112Drugs (16)
CMF-34362SPEF2up-regulateshsa-mir-20brepressesR-397443Drugs (16)
CMF-34396WDR90up-regulateshsa-mir-106brepressesR-397216Drugs (16)
CMF-34403WDR90up-regulateshsa-mir-93repressesR-3974416Drugs (16)
CMF-34586MYH8down-regulateshsa-mir-346repressesR-3972014Drugs (16)
CMF-34619MYH8down-regulateshsa-mir-129repressesR-39715550Drugs (16)
CMF-34705CYP4F12up-regulateshsa-mir-93repressesR-3974414Drugs (16)
CMF-34918KIAA1549down-regulateshsa-mir-346repressesR-3972013Drugs (16)
CMF-34979SIRPGdown-regulateshsa-mir-346repressesR-3972018Drugs (16)
CMF-35005OTOAup-regulateshsa-mir-758repressesR-39711Drugs (16)
CMF-35029FGFR3down-regulateshsa-mir-346repressesR-3972016Drugs (16)
CMF-35054FGFR3down-regulateshsa-mir-454-3prepressesR-3973129Drugs (16)
CMF-35086FGFR3down-regulateshsa-mir-20brepressesR-3974426Drugs (16)
CMF-35215ATRXup-regulateshsa-mir-139repressesR-3975858Drugs (16)
CMF-35273ATRXup-regulateshsa-mir-454-3prepressesR-3973122Drugs (16)
CMF-35477ATRXup-regulateshsa-mir-106brepressesR-3972112Drugs (16)
CMF-35493ATRXup-regulateshsa-mir-17-3prepressesR-3975231Drugs (16)
CMF-35526ATRXup-regulateshsa-mir-93repressesR-3974435Drugs (16)
CMF-35713ATRXup-regulateshsa-mir-20brepressesR-3974435Drugs (16)
CMF-35976AHNAK2up-regulateshsa-mir-106brepressesR-3972116Drugs (16)
CMF-35998AHNAK2up-regulateshsa-mir-93repressesR-3974426Drugs (16)
CMF-36026AHNAK2up-regulateshsa-mir-20brepressesR-3974426Drugs (16)
CMF-36069DPPA4down-regulateshsa-mir-93repressesR-3974422Drugs (16)
CMF-36157TNK2up-regulateshsa-mir-17-3prepressesR-3975240Drugs (16)
CMF-36423RANBP6up-regulateshsa-mir-93repressesR-397441Drugs (16)
CMF-36692ATP8A2up-regulateshsa-mir-454-3prepressesR-3973127Drugs (16)
CMF-36733ATP8A2up-regulateshsa-mir-17-3prepressesR-3975240Drugs (16)
CMF-36763ATP8A2up-regulateshsa-mir-93repressesR-3974432Drugs (16)
CMF-36797ATP8A2up-regulateshsa-mir-20brepressesR-3974431Drugs (16)
CMF-37202CYP4F22down-regulateshsa-mir-129repressesR-39715535Drugs (16)
CMF-37384WDFY3down-regulateshsa-mir-106brepressesR-397217Drugs (16)
CMF-37408ACACBdown-regulateshsa-mir-20brepressesR-3974415Drugs (16)
CMF-37675ADAMTS8up-regulateshsa-mir-758repressesR-39711Drugs (16)
CMF-37700ADAMTS8up-regulateshsa-mir-17-3prepressesR-3975240Drugs (16)
CMF-37812ANKRD33down-regulateshsa-mir-106brepressesR-397215Drugs (16)
CMF-37821ANKRD33down-regulateshsa-mir-93repressesR-3974425Drugs (16)
CMF-37937SLC5A12down-regulateshsa-mir-17-3prepressesR-3975213Drugs (16)
CMF-38009PPEF2down-regulateshsa-mir-346repressesR-3972016Drugs (16)
CMF-38057FAM110Bup-regulateshsa-mir-139repressesR-397588Drugs (16)
CMF-38090OR51F1up-regulateshsa-mir-106brepressesR-3972117Drugs (16)
CMF-38110OR51F1up-regulateshsa-mir-93repressesR-3974435Drugs (16)
CMF-38324ZNF845up-regulateshsa-mir-454-3prepressesR-3973127Drugs (16)
CMF-38428KCNB2down-regulateshsa-mir-106brepressesR-3972115Drugs (16)
CMF-38452KCNB2down-regulateshsa-mir-17-3prepressesR-3975236Drugs (16)
CMF-38480KCNB2down-regulateshsa-mir-93repressesR-3974427Drugs (16)
CMF-38500NFIXdown-regulateshsa-mir-346repressesR-3972017Drugs (16)
CMF-38570CPNE8down-regulateshsa-mir-17-3prepressesR-3975228Drugs (16)
CMF-38591CPNE8down-regulateshsa-mir-93repressesR-3974420Drugs (16)
CMF-38769FLNAup-regulateshsa-mir-106brepressesR-397217Drugs (16)
CMF-38989SGIP1down-regulateshsa-mir-17-3prepressesR-3975226Drugs (16)
CMF-39013SGIP1down-regulateshsa-mir-93repressesR-3974423Drugs (16)
CMF-39036SGIP1down-regulateshsa-mir-20brepressesR-3974423Drugs (16)
CMF-39329INPP5Jup-regulateshsa-mir-758repressesR-39711Drugs (16)
CMF-39347UPF1down-regulateshsa-mir-346repressesR-3972016Drugs (16)
CMF-39363UPF1down-regulateshsa-mir-139repressesR-3975813Drugs (16)
CMF-39562NF1down-regulateshsa-mir-106brepressesR-3972120Drugs (16)
CMF-39630NF1down-regulateshsa-mir-93repressesR-3974431Drugs (16)
CMF-39721NF1down-regulateshsa-mir-20brepressesR-3974431Drugs (16)
CMF-39775RPSAP58down-regulateshsa-mir-17-3prepressesR-3975240Drugs (16)
CMF-39934TDRD9down-regulateshsa-mir-106brepressesR-3972121Drugs (16)
CMF-39967TDRD9down-regulateshsa-mir-17-3prepressesR-3975242Drugs (16)
CMF-40205KRTAP4-7down-regulateshsa-mir-17-3prepressesR-3975217Drugs (16)
CMF-40428IDH1up-regulateshsa-mir-346repressesR-3972020Drugs (16)
CMF-40459IDH1up-regulateshsa-mir-139repressesR-3975858Drugs (16)
CMF-40517IDH1up-regulateshsa-mir-454-3prepressesR-3973122Drugs (16)
CMF-40765IDH1up-regulateshsa-mir-106brepressesR-3972112Drugs (16)
CMF-40781IDH1up-regulateshsa-mir-17-3prepressesR-3975231Drugs (16)
CMF-40816IDH1up-regulateshsa-mir-93repressesR-3974435Drugs (16)
CMF-41003IDH1up-regulateshsa-mir-20brepressesR-3974435Drugs (16)
CMF-41226TP53up-regulateshsa-mir-346repressesR-3972020Drugs (16)
CMF-41341TP53up-regulateshsa-mir-17-3prepressesR-3975252Drugs (16)
CMF-41384TP53up-regulateshsa-mir-93repressesR-3974444Drugs (16)
CMF-41546TP53up-regulateshsa-mir-20brepressesR-3974444Drugs (16)
CMF-41776IQSEC3up-regulateshsa-mir-454-3prepressesR-3973125Drugs (16)
CMF-41907IQSEC3up-regulateshsa-mir-20brepressesR-3974434Drugs (16)
CMF-42015CD163up-regulateshsa-mir-149repressesR-3975116Drugs (16)
CMF-42146NAALADL1down-regulateshsa-mir-346repressesR-3972018Drugs (16)
CMF-42169NAALADL1down-regulateshsa-mir-139repressesR-3975814Drugs (16)
CMF-42289MVPup-regulateshsa-mir-17-3prepressesR-3975212Drugs (16)
CMF-42327SDK1down-regulateshsa-mir-346repressesR-3972014Drugs (16)
CMF-42358SDK1down-regulateshsa-mir-758repressesR-39711Drugs (16)
CMF-42363SDK1down-regulateshsa-mir-129repressesR-39715522Drugs (16)
CMF-42469FSTL5down-regulateshsa-mir-17-3prepressesR-3975216Drugs (16)
CMF-42742AQP10up-regulateshsa-mir-758repressesR-39711Drugs (16)
CMF-42752AQP10up-regulateshsa-mir-129repressesR-39715541Drugs (16)
CMF-42963ESRRBdown-regulateshsa-mir-454-3prepressesR-3973115Drugs (16)
CMF-42998ESRRBdown-regulateshsa-mir-17-3prepressesR-3975228Drugs (16)
CMF-43038ESRRBdown-regulateshsa-mir-20brepressesR-3974428Drugs (16)
CMF-43185PRKDCdown-regulateshsa-mir-346repressesR-3972016Drugs (16)