Regulon

Regulon: R-373

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
32	2.71651	1	12	Pr-155

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5606	ENSG00000034152	MAP2K3	J3QL77
11284	ENSG00000039650	PNKP	Q96T60
5566	ENSG00000072062	PRKACA	P17612
5817	ENSG00000073008	PVR	A0A0C4DG49
6560	ENSG00000124067	SLC12A4	Q9UP95
6385	ENSG00000124145	SDC4	P31431
9322	ENSG00000125733	TRIP10	W4VSQ9
6238	ENSG00000125844	RRBP1	Q9P2E9
3949	ENSG00000130164	LDLR	P01130
3911	ENSG00000130702	LAMA5	O15230
1847	ENSG00000138166	DUSP5	Q16690
5371	ENSG00000140464	PML	P29590
5045	ENSG00000140564	FURIN	P09958
2064	ENSG00000141736	ERBB2	P04626
1969	ENSG00000142627	EPHA2	P29317
114884	ENSG00000144645	OSBPL10	Q9BXB5
4000	ENSG00000160789	LMNA	P02545
4665	ENSG00000166886	NAB2	Q15742
4862	ENSG00000170485	NPAS2	Q99743
54961	ENSG00000172830	SSH3	Q8TE77
1717	ENSG00000172893	DHCR7	B4E1K5
9986	ENSG00000173653	RCE1	Q9Y256
23612	ENSG00000174307	PHLDA3	Q9Y5J5
8061	ENSG00000175592	FOSL1	P15407
977	ENSG00000177697	CD151	A0A024RCB3
4059	ENSG00000187244	BCAM	P50895
29780	ENSG00000188677	PARVB	Q9HBI1
2050	ENSG00000196411	EPHB4	P54760
26037	ENSG00000197555	SIPA1L1	O43166
51232	ENSG00000277354	CRIM1	Q53TH9
22904	ENSG00000278788	SBNO2	Q9Y2G9
81	ENSG00000282844	ACTN4	O43707

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
POZIOTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor inhibitor	2	0
MM-111	ERBB2	Unknown	INHIBITOR	ErbB-2/ErbB-3 heterodimer inhibitor	2	0
TRASTUZUMAB DERUXTECAN	TOP1	Antibody	INHIBITOR	DNA topoisomerase I inhibitor	4	0
VARLITINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	2	0
CUDC-101	HDAC1	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
LAPATINIB DITOSYLATE	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
TUCATINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	0
HEMAY-022	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
MP-412	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
TRASTUZUMAB EMTANSINE	ERBB2	Antibody	INHIBITOR	Tubulin inhibitor	4	0
ZENOCUTUZUMAB	ERBB2	Antibody	INHIBITOR	ErbB-2/ErbB-3 heterodimer inhibitor	2	0
CANERTINIB DIHYDROCHLORIDE	ERBB4	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	3	0
NERATINIB MALEATE	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-4 inhibitor	4	0
MUBRITINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
LAPATINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
SAPITINIB	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	2	0
NERATINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	2
BMS-690514	KDR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
AC-480	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
DACOMITINIB	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-4 inhibitor	4	2
KBP5209	ERBB2	Unknown	INHIBITOR	Epidermal growth factor receptor inhibitor	1	0
TARLOXOTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor inhibitor	2	0
VANDETANIB	EPHA2	Small molecule	INHIBITOR	Tyrosine-protein kinase SRC inhibitor	4	2
ALLITINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
ERTUMAXOMAB	ERBB2	Antibody	CROSS-LINKING AGENT	T-cell surface glycoprotein CD3 epsilon chain cross-linking agent	2	0
TRASTUZUMAB DUOCARMAZINE	ERBB2	Antibody	BINDING AGENT	Receptor protein-tyrosine kinase erbB-2 binding agent	3	0
MARGETUXIMAB	ERBB2	Antibody	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	0
TRASTUZUMAB	ERBB2	Antibody	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	0
T-DM1	ERBB2	Antibody	BINDING AGENT	Receptor protein-tyrosine kinase erbB-2 binding agent	3	0
CANERTINIB	ERBB4	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	3	0
BDTX189	EGFR	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Epidermal growth factor receptor erbB1 negative allosteric modulator	1	0
JNJ-26483327	ERBB2	Small molecule	INHIBITOR	Tyrosine-protein kinase FYN inhibitor	1	0
TESEVATINIB	ERBB2	Small molecule	INHIBITOR	Ephrin type-B receptor 4 inhibitor	3	2
JI-101	PDGFRB	Small molecule	INHIBITOR	Ephrin type-B receptor 4 inhibitor	2	0
AFATINIB DIMALEATE	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	0
CP-724714	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	2	0
AFATINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	1
TG100-801	EPHB4	Small molecule	INHIBITOR	SRC inhibitor	2	0
OCRIPLASMIN	LAMA2	Enzyme	PROTEOLYTIC ENZYME	Fibronectin proteolytic enzyme	4	0
AEE-788	KDR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	1
PYROTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
TAK-285	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	1	0
REGORAFENIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	4	2
PERTUZUMAB	ERBB2	Antibody	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	0
GSK-690693	PRKACB	Small molecule	INHIBITOR	Protein kinase C (PKC) inhibitor	1	0
GANCOTAMAB	TOP2A	Antibody	INHIBITOR	DNA topoisomerase II alpha inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-373

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01103	ZNF292	down-regulates	SPI1	activates	R-373	25	12	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-09068	FLT1	down-regulates	SPI1	activates	R-373	25	2	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-10100	TACR3	down-regulates	SPI1	activates	R-373	25	3	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-12262	GPR98	down-regulates	SPI1	activates	R-373	25	13	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-13068	OTC	up-regulates	SPI1	activates	R-373	25	3	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-13781	ADAMTS8	down-regulates	SPI1	activates	R-373	25	12	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-14133	CD1D	up-regulates	SPI1	activates	R-373	25	5	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-16997	FLNA	down-regulates	SPI1	activates	R-373	25	2	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-22145	PDGFRA	down-regulates	SPI1	activates	R-373	25	9	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-23717	TP53	down-regulates	SPI1	activates	R-373	25	15	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-29194	AQP10	down-regulates	SPI1	activates	R-373	25	8	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB
CMF-30374	RNF130	down-regulates	SPI1	activates	R-373	25	5	Drugs (47) Regulator Drugs (0) Regulon Drugs (47) POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, DASATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, REGORAFENIB, PERTUZUMAB, GSK-690693, GANCOTAMAB

Regulon: R-373

Regulon Summary

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Causal Flows

Causal Mechanistic Flows for Regulon R-373

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