Regulon

Regulon: R-3580

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
102.82852112Pr-3Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
1356 ENSG00000047457 CP D6RE86
79670 ENSG00000083223 ZCCHC6 Q5VYS8
59 ENSG00000107796 ACTA2 P62736
1362 ENSG00000108582 CPD O75976
6648 ENSG00000112096 SOD2
411 ENSG00000113273 ARSB P15848
1824 ENSG00000134755 DSC2 Q02487
5031 ENSG00000171631 P2RY6 Q15077
23765 ENSG00000177663 IL17RA Q96F46
5770 ENSG00000196396 PTPN1 P18031

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
BRODALUMABIL17RAAntibodyANTAGONISTInterleukin-17 receptor A antagonist40
DIQUAFOSOLP2RY2Small moleculeAGONISTPyrimidinergic receptor P2Y6 agonist30
DIQUAFOSOL TETRASODIUMP2RY2Small moleculeAGONISTPyrimidinergic receptor P2Y6 agonist30

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3580

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-02696UBE3Cdown-regulatesHLXactivatesR-3580101Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-06337MATN4down-regulatesHLXactivatesR-3580102Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-08596FOXR2down-regulatesHLXactivatesR-3580102Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-09028NALCNdown-regulatesHLXactivatesR-3580102Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-09270RP1down-regulatesHLXactivatesR-3580103Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-12294GPR98down-regulatesHLXactivatesR-3580104Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-13796ADAMTS8down-regulatesHLXactivatesR-3580103Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-19388NF1up-regulatesHLXactivatesR-35801010Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-26260CEP250down-regulatesHLXactivatesR-3580103Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-27233PCDH11Xdown-regulatesHLXactivatesR-3580101Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-28404MYO9Bdown-regulatesHLXactivatesR-3580105Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-30199OR4K13down-regulatesHLXactivatesR-3580101Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

BRODALUMAB, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM