Regulon

Regulon: R-356

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
502.42291157Pr-7Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
23129 ENSG00000004399 PLXND1 Q9Y4D7
221 ENSG00000006534 ALDH3B1 P43353
920 ENSG00000010610 CD4 P01730
695 ENSG00000010671 BTK Q06187
7305 ENSG00000011600 TYROBP O43914
9961 ENSG00000013364 MVP Q14764
3459 ENSG00000027697 IFNGR1 A0A2R8Y4U4
2896 ENSG00000030582 GRN P28799
8832 ENSG00000066294 CD84 Q9UIB8
3912 ENSG00000091136 LAMB1 P07942
8829 ENSG00000099250 NRP1 O14786
1522 ENSG00000101160 CTSZ Q9UBR2
11151 ENSG00000102879 CORO1A P31146
22797 ENSG00000105967 TFEC O14948
9144 ENSG00000108639 SYNGR2 O43760
9404 ENSG00000110031 LPXN O60711
51296 ENSG00000110446 SLC15A3 Q8IY34
51411 ENSG00000110934 BIN2 Q9UBW5
2335 ENSG00000115414 FN1 P02751
56944 ENSG00000116774 OLFML3 Q9NRN5
1441 ENSG00000119535 CSF3R Q99062
718 ENSG00000125730 C3 P01024
27180 ENSG00000129450 SIGLEC9 Q9Y336
10095 ENSG00000130429 ARPC1B O15143
9535 ENSG00000130755 GMFG O60234
4245 ENSG00000131446 MGAT1 P26572
241 ENSG00000132965 ALOX5AP P20292
1794 ENSG00000134516 DOCK2 Q92608
3936 ENSG00000136167 LCP1 P13796
7409 ENSG00000141968 VAV1 P15498
6518 ENSG00000142583 SLC2A5 P22732
10184 ENSG00000145685 LHFPL2 Q6ZUX7
51571 ENSG00000153310 FAM49B Q9NUQ9
23643 ENSG00000154589 LY96 Q9Y6Y9
11326 ENSG00000155659 VSIG4 Q9Y279
912 ENSG00000158473 CD1D P15813
3689 ENSG00000160255 ITGB2 D3DSM0
3570 ENSG00000160712 IL6R P08887
25903 ENSG00000162745 OLFML2B Q68BL8
5966 ENSG00000162924 REL Q04864
11314 ENSG00000167851 CD300A Q9UGN4
3684 ENSG00000169896 ITGAM P11215
929 ENSG00000170458 CD14 P08571
5293 ENSG00000171608 PIK3CD O00329
7100 ENSG00000187554 TLR5 B1AZ06
51284 ENSG00000196664 TLR7 Q9NYK1
51703 ENSG00000197142 ACSL5 Q9ULC5
240 ENSG00000275565 ALOX5 P09917
4689 ENSG00000275990 NCF4 Q15080
5265 ENSG00000277377 SERPINA1 P01009

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
PF-04691502PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
UMBRALISIBPIK3CDSmall moleculeINHIBITORTyrosine-protein kinase ABL inhibitor40
FIBOFLAPON SODIUMALOX5APSmall moleculeINHIBITOR5-lipoxygenase activating protein inhibitor30
BGT-226PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
SONOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
CSL-324CSF3RUnknownANTAGONISTGranulocyte colony stimulating factor receptor antagonist20
HYDROXYCHLOROQUINETLR7Small moleculeANTAGONISTToll-like receptor 7 antagonist42
PARSACLISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor30
INTERFERON GAMMA-1BIFNGR1ProteinAGONISTInterferon gamma receptor agonist40
VOXTALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor21
BMS-986142BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
HM-71224BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor10
NEMIRALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
RP-6530PIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor10
APITOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
AME-133VITGB2AntibodyINHIBITORIntegrin beta-2 inhibitor20
DS-7423PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
GSK-2269557PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
L19IL2FN1AntibodyBINDING AGENTFibronectin binding agent30
INCB-40093PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
MSC-2364447BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor10
PAXALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
AS-1409FN1AntibodyBINDING AGENTFibronectin binding agent10
PICTILISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
PF-06651600BTKSmall moleculeINHIBITORTEC family kinase inhibitor30
AMY-101C3ProteinINHIBITORComplement C3 inhibitor20
LIPEGFILGRASTIMCSF3RProteinAGONISTGranulocyte colony stimulating factor receptor agonist40
ABIVERTINIBBTKSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor30
VRC-01LSCD4UnknownBINDING AGENTT-cell surface antigen CD4 binding agent20
ABIVERTINIB MALEATEEGFRSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
TG100-115PIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor20
VS-5584PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
COPANLISIBPIK3CASmall moleculeINHIBITORPI3-kinase p110-alpha subunit inhibitor40
SAMOTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
VOBARILIZUMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor20
VESATOLIMODTLR7Small moleculeACTIVATORToll-like receptor 7 activator20
DUVELISIBPIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor40
L19TNFAFN1AntibodyBINDING AGENTFibronectin binding agent20
AZD-8848TLR7Small moleculeAGONISTToll-like receptor 7 agonist20
EFALIZUMABITGALAntibodyINHIBITORIntegrin alpha-L/beta-2 (LFA-1) inhibitor40
DACTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor30
FILGRASTIMCSF3RProteinAGONISTGranulocyte colony stimulating factor receptor agonist40
ZANDELISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor30
TOCILIZUMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor42
AZD-8186PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor10
GNF-Pf-5468PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
WX-037PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
RILZABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
BALUGRASTIMCSF3RProteinAGONISTGranulocyte colony stimulating factor receptor agonist20
SPEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
PILARALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor21
TASELISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor30
L19SIP 131IFN1AntibodyOTHERFibronectin other20
AMG-319PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
IBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor41
HYDROXYCHLOROQUINE SULFATETLR7Small moleculeANTAGONISTToll-like receptor 7 antagonist40
COPANLISIB HYDROCHLORIDEPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor40
TENALISIBPIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor20
SELETALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
GEDATOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
OMIPALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
SARILUMABIL6RAntibodyANTAGONISTInterleukin-6 receptor alpha subunit antagonist40
UMBRALISIB TOSYLATECSNK1ESmall moleculeINHIBITORTyrosine-protein kinase ABL inhibitor40
ENTOLIMODTLR5UnknownAGONISTToll-like receptor 5 agonist20
IDELALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor40
ZANUBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor40
FIMEPINOSTATPIK3CDSmall moleculeINHIBITORPI3-kinase p110-alpha subunit inhibitor20
SATRALIZUMABIL6RAntibodyANTAGONISTIL6Ralpha/GP130 antagonist40
EVOBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
CPG-52852TLR7Small moleculeAGONISTToll-like receptor 7 agonist20
IMIQUIMODTLR7Small moleculeAGONISTToll-like receptor 7 agonist41
IC14CD14AntibodyINHIBITORMonocyte differentiation antigen CD14 inhibitor20
TREGALIZUMABCD4AntibodyAGONISTT-cell surface antigen CD4 agonist20
ERITORAN TETRASODIUMTLR4Small moleculeANTAGONISTToll-like receptor 4/MD-2 antagonist30
SPEBRUTINIB BESYLATEBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
PEGCETACOPLANC3ProteinINHIBITORComplement C3 inhibitor40
LENOGRASTIMCSF3RProteinAGONISTGranulocyte colony stimulating factor receptor agonist40
POSELTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
LIFITEGRASTITGALSmall moleculeANTAGONISTIntegrin alpha-L/beta-2 (LFA-1) antagonist40
VB-201CD14Small moleculeINHIBITORToll-like receptor 2 inhibitor20
ACALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
ZANOLIMUMABCD4AntibodyOTHERT-cell surface antigen CD4 other30
GSK-2245035TLR7Small moleculeAGONISTToll-like receptor 7 agonist20
VELIFLAPONALOX5APSmall moleculeINHIBITOR5-lipoxygenase activating protein inhibitor30
PIRTOBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
TELRATOLIMODTLR8Small moleculeAGONISTToll-like receptor 8 agonist10
IBALIZUMABCD4AntibodyINHIBITORT-cell surface antigen CD4 inhibitor40
OCRIPLASMINLAMA2EnzymePROTEOLYTIC ENZYMEFibronectin proteolytic enzyme40
CAL-263PIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor10
UB-421CD4UnknownINHIBITORT-cell surface antigen CD4 inhibitor30
ACALABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor41
ERITORANTLR4Small moleculeANTAGONISTToll-like receptor 4/MD-2 antagonist30
ELSUBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
BRANEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
LENIOLISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
PA-799PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
TIRABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
FENEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
LEVILIMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor30
GSK-1059615PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
PEGFILGRASTIMCSF3RProteinAGONISTGranulocyte colony stimulating factor receptor agonist40
BUPARLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor32
VESENCUMABNRP1AntibodyINHIBITORNeuropilin-1 inhibitor10
SF-1126PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
ORELABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
FIBOFLAPONALOX5APSmall moleculeINHIBITOR5-lipoxygenase activating protein inhibitor30
AL-78898AC3UnknownINHIBITORComplement C3 inhibitor20
PANULISIBACVRL1Small moleculeINHIBITORSerine/threonine-protein kinase receptor R3 inhibitor10

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-356

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01612MCM6up-regulatesATF5activatesR-356146Drugs (108)
CMF-15387DSEup-regulatesATF5activatesR-356143Drugs (108)
CMF-17978PRPF40Bdown-regulatesATF5activatesR-3561410Drugs (108)
CMF-27600ANKRD36up-regulatesATF5activatesR-356145Drugs (108)
CMF-33877ZNF292up-regulateshsa-mir-125brepressesR-356108Drugs (108)
CMF-33884SKAP2down-regulateshsa-mir-328repressesR-356277Drugs (108)
CMF-33917SDPRdown-regulateshsa-mir-328repressesR-356273Drugs (108)
CMF-34700LAMC3up-regulateshsa-mir-130brepressesR-35693Drugs (108)
CMF-34854NEBdown-regulateshsa-mir-328repressesR-356275Drugs (108)
CMF-35103HTR5Adown-regulateshsa-mir-328repressesR-356275Drugs (108)
CMF-35741SUSD1up-regulateshsa-mir-7repressesR-356182Drugs (108)
CMF-35743SUSD1up-regulateshsa-mir-551brepressesR-356226Drugs (108)
CMF-35964AHNAK2up-regulateshsa-mir-125brepressesR-356105Drugs (108)
CMF-35985AHNAK2up-regulateshsa-mir-95repressesR-356735Drugs (108)
CMF-36130TNK2up-regulateshsa-mir-125brepressesR-356107Drugs (108)
CMF-36153TNK2up-regulateshsa-mir-17-3prepressesR-3565240Drugs (108)
CMF-36245TRIM6-TRIM34up-regulateshsa-mir-125brepressesR-356105Drugs (108)
CMF-36266KIF4Aup-regulateshsa-mir-130brepressesR-35696Drugs (108)
CMF-36671ALBdown-regulateshsa-mir-328repressesR-356274Drugs (108)
CMF-36675ALBdown-regulateshsa-mir-551brepressesR-356224Drugs (108)
CMF-36729ATP8A2up-regulateshsa-mir-17-3prepressesR-3565240Drugs (108)
CMF-37174CYP4F22down-regulateshsa-mir-7repressesR-3561817Drugs (108)
CMF-37696ADAMTS8up-regulateshsa-mir-17-3prepressesR-3565240Drugs (108)
CMF-37846PRKCDup-regulateshsa-mir-328repressesR-3562722Drugs (108)
CMF-37866PRKCDup-regulateshsa-mir-130brepressesR-35696Drugs (108)
CMF-37915C1orf177down-regulateshsa-mir-551brepressesR-356225Drugs (108)
CMF-37962COL6A2down-regulateshsa-mir-17-3prepressesR-3565217Drugs (108)
CMF-38024PPEF2down-regulateshsa-mir-551brepressesR-356223Drugs (108)
CMF-38075OR51F1up-regulateshsa-mir-551brepressesR-356225Drugs (108)
CMF-38403KCNB2down-regulateshsa-mir-551brepressesR-356225Drugs (108)
CMF-38449KCNB2down-regulateshsa-mir-17-3prepressesR-3565236Drugs (108)
CMF-38518NFIXdown-regulateshsa-mir-328repressesR-356277Drugs (108)
CMF-38569CPNE8down-regulateshsa-mir-17-3prepressesR-3565228Drugs (108)
CMF-38963PRPF40Bup-regulateshsa-mir-125brepressesR-3561010Drugs (108)
CMF-38977SGIP1down-regulateshsa-mir-363repressesR-356191Drugs (108)
CMF-38986SGIP1down-regulateshsa-mir-17-3prepressesR-3565226Drugs (108)
CMF-39004SGIP1down-regulateshsa-mir-130brepressesR-35691Drugs (108)
CMF-39101DNMBPdown-regulateshsa-mir-328repressesR-356276Drugs (108)
CMF-39143DNMBPdown-regulateshsa-mir-17-3prepressesR-3565235Drugs (108)
CMF-39323INPP5Jup-regulateshsa-mir-488repressesR-3561910Drugs (108)
CMF-39490NF1down-regulateshsa-mir-551brepressesR-3562218Drugs (108)
CMF-39532NF1down-regulateshsa-mir-488repressesR-3561912Drugs (108)
CMF-39546NF1down-regulateshsa-mir-125brepressesR-356109Drugs (108)
CMF-39580NF1down-regulateshsa-mir-95repressesR-3567347Drugs (108)
CMF-39771RPSAP58down-regulateshsa-mir-17-3prepressesR-3565240Drugs (108)
CMF-39825UGT2B4down-regulateshsa-mir-149repressesR-3565135Drugs (108)
CMF-39963TDRD9down-regulateshsa-mir-17-3prepressesR-3565242Drugs (108)
CMF-40319MUC17down-regulateshsa-mir-125brepressesR-356109Drugs (108)
CMF-41248TP53up-regulateshsa-mir-551brepressesR-3562214Drugs (108)
CMF-41302TP53up-regulateshsa-mir-363repressesR-3561915Drugs (108)
CMF-41337TP53up-regulateshsa-mir-17-3prepressesR-3565252Drugs (108)
CMF-42164NAALADL1down-regulateshsa-mir-328repressesR-356277Drugs (108)
CMF-42304PCDH11Xup-regulateshsa-mir-95repressesR-356733Drugs (108)
CMF-42341SDK1down-regulateshsa-mir-328repressesR-356276Drugs (108)
CMF-42357SDK1down-regulateshsa-mir-7repressesR-3561814Drugs (108)
CMF-42395KRTAP20-2down-regulateshsa-mir-7repressesR-3561815Drugs (108)
CMF-43260SALL4up-regulateshsa-mir-125brepressesR-356106Drugs (108)