Regulon

Regulon: R-2285

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
6	2.48321	1	10	Pr-104

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5742	ENSG00000095303	PTGS1	P23219
684	ENSG00000130303	BST2	Q10589
9023	ENSG00000138135	CH25H	O95992
55080	ENSG00000139192	TAPBPL	Q9BX59
55281	ENSG00000146859	TMEM140	Q9NV12
3990	ENSG00000166035	LIPC	P11150

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
IBUPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	2
PIRPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
PHENYLBUTAZONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
ACETAMINOPHEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	2
OXYPHENBUTAZONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BROMFENAC SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
OLSALAZINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
LORNOXICAM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
FLURBIPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DIPYRONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
FENOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
ANTIPYRINE	PTGS1	Small molecule	INHIBITOR	Cyclooxygenase-1 inhibitor	4	0
NAPROXEN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DEXKETOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
ASPIRIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	2
ESFLURBIPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	3	0
ALOXIPRIN	PTGS2	Unknown	INHIBITOR	Cyclooxygenase inhibitor	4	0
INDOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
KETOROLAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
INDOMETHACIN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BENZYDAMINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
NAPROXEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DICLOFENAC EPOLAMINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
FENOPROFEN CALCIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
MECLOFENAMIC ACID	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
OLSALAZINE SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
APAZONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
MESALAMINE	PPARG	Small molecule	AGONIST	Peroxisome proliferator-activated receptor gamma agonist	4	0
ACEMETACIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
IBUPROFEN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BALSALAZIDE DISODIUM	PPARG	Small molecule	INHIBITOR	Arachidonate 5-lipoxygenase inhibitor	4	0
NEPAFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DICLOFENAC POTASSIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
IBUPROFEN LYSINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
PIROXICAM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
SUPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
SULFASALAZINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	1
MECLOFENAMATE SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
LOXOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	3	0
DICLOFENAC SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BENZYDAMINE HYDROCHLORIDE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
TOLMETIN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
KETOROLAC TROMETHAMINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
ALCLOFENAC	PTGS1	Small molecule	INHIBITOR	Cyclooxygenase-1 inhibitor	4	0
DEXIBUPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
SULINDAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
KETOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BALSALAZIDE	PPARG	Small molecule	INHIBITOR	Arachidonate 5-lipoxygenase inhibitor	4	0
NAPROXCINOD	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	3	0
TOLMETIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DICLOFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BISMUTH SUBSALICYLATE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
MEFENAMIC ACID	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
GLAFENINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DIFLUNISAL	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BROMFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
NAPROXEN ETEMESIL	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	2	0
INDOMETHACIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
OXAPROZIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2285

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-04014	DSP	up-regulates	STAT6	activates	R-2285	11	4	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-04602	LAMC3	down-regulates	STAT6	activates	R-2285	11	4	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-08613	FOXR2	down-regulates	STAT6	activates	R-2285	11	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-10013	ALB	up-regulates	STAT6	activates	R-2285	11	1	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-16866	OR5I1	down-regulates	STAT6	activates	R-2285	11	3	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-17560	CNTNAP3	up-regulates	STAT6	activates	R-2285	11	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-20150	TDRD9	up-regulates	STAT6	activates	R-2285	11	3	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-21925	PRAME	up-regulates	STAT6	activates	R-2285	11	2	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-22127	OR2T34	down-regulates	STAT6	activates	R-2285	11	6	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN
CMF-22184	PDGFRA	down-regulates	STAT6	activates	R-2285	11	4	Drugs (59) Regulator Drugs (0) Regulon Drugs (59) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, ACETAMINOPHEN, OXYPHENBUTAZONE, BROMFENAC SODIUM, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, ANTIPYRINE, NAPROXEN SODIUM, DEXKETOPROFEN, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, MESALAMINE, ACEMETACIN, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, ALCLOFENAC, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN

Regulon: R-2285

Regulon Summary

Regulon Genes

Regulon Drugs

Causal Flows

Causal Mechanistic Flows for Regulon R-2285

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)

Regulator Drugs (0)

Regulon Drugs (59)