Regulon

Regulon: R-1848

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
36	3.05319	1	8	Pr-43

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
54677	ENSG00000005469	CROT	Q9UKG9
9902	ENSG00000011028	MRC2	Q9UBG0
7132	ENSG00000067182	TNFRSF1A	P19438
6717	ENSG00000075142	SRI	P30626
51619	ENSG00000078967	UBE2D4	Q9Y2X8
7205	ENSG00000087077	TRIP6	Q15654
54498	ENSG00000088826	SMOX	Q9NWM0
4897	ENSG00000091129	NRCAM	Q92823
8406	ENSG00000101955	SRPX	P78539
760	ENSG00000104267	CA2	P00918
5445	ENSG00000105854	PON2	Q15165
55240	ENSG00000115107	STEAP3	A1P3F0
2202	ENSG00000115380	EFEMP1	Q12805
1647	ENSG00000116717	GADD45A	P24522
1266	ENSG00000117519	CNN3	Q15417
2152	ENSG00000117525	F3	P13726
5825	ENSG00000117528	ABCD3	P28288
57134	ENSG00000117643	MAN1C1	Q9NR34
10267	ENSG00000132329	RAMP1	O60894
2012	ENSG00000134531	EMP1	P54849
967	ENSG00000135404	CD63	P08962
92579	ENSG00000141349	G6PC3	K7ENK1
8324	ENSG00000155760	FZD7	O75084
1827	ENSG00000159200	RCAN1	P53805
5806	ENSG00000163661	PTX3	P26022
9263	ENSG00000164543	STK17A	Q9UEE5
9122	ENSG00000168679	SLC16A4	O15374
1140	ENSG00000170175	CHRNB1	P11230
23333	ENSG00000173852	DPY19L1	Q2PZI1
114897	ENSG00000173918	C1QTNF1	Q9BXJ1
1466	ENSG00000175183	CSRP2	Q16527
56674	ENSG00000175348	TMEM9B	Q9NQ34
977	ENSG00000177697	CD151	A0A024RCB3
24147	ENSG00000179431	FJX1	Q86VR8
25840	ENSG00000185432	METTL7A	A0A024R118
3269	ENSG00000196639	HRH1	P35367

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase
CISATRACURIUM	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
PROMETHAZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPROLIDINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LEVOCETIRIZINE DIHYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
KETOTIFEN FUMARATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
PYRILAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPELENNAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
GSK-1995057	TNFRSF1A	Antibody	INHIBITOR	Tumor necrosis factor receptor R1 inhibitor	1
RUPATADINE	PTAFR	Small molecule	ANTAGONIST	Platelet activating factor receptor antagonist	3
DOXYLAMINE SUCCINATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CISATRACURIUM BESYLATE	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
MECLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BEPOTASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BROMPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CLEMASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
OLOPATADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
SUXAMETHONIUM	CHRNA1	Small molecule	AGONIST	Muscle-type nicotinic acetylcholine receptor agonist	4
PRAMLINTIDE	RAMP1	Protein	AGONIST	Amylin receptor AMY1, CALCR/RAMP1 agonist	4
CYPROHEPTADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BRINZOLAMIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
EPINASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TERFENADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CARBINOXAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DEXCHLORPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
CHLORPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DORZOLAMIDE HYDROCHLORIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
DICHLORPHENAMIDE	CA4	Small molecule	INHIBITOR	Carbonic anhydrase IV inhibitor	4
DEXBROMPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
OLOPATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ASTEMIZOLE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CHLORPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
HISTAMINE	HRH1	Small molecule	AGONIST	Histamine H1 receptor agonist	4
LEVOCABASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DEXBROMPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MIVACURIUM	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
EBASTINE	HRH1	Small molecule	INVERSE AGONIST	Histamine H1 receptor inverse agonist	3
SULTHIAME	CA2	Small molecule	INHIBITOR	Carbonic anhydrase inhibitor	4
CINNARIZINE	HRH1	Small molecule	BLOCKER	Voltage-gated L-type calcium channel blocker	4
HYDROXYZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LORATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DORZOLAMIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
LY2624803	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	2
ROCURONIUM BROMIDE	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
PHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACETAZOLAMIDE	CA4	Small molecule	INHIBITOR	Carbonic anhydrase XII inhibitor	4
TRIPROLIDINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHAZOLAMIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
MIVACURIUM CHLORIDE	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
PRAMLINTIDE ACETATE	RAMP1	Protein	AGONIST	Amylin receptor AMY1, CALCR/RAMP1 agonist	4
DIPHENHYDRAMINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIMIPRAMINE	SLC6A2	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4
BUCLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EPINASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
KETOTIFEN	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
FEXOFENADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BILASTINE	HRH1	Small molecule	INVERSE AGONIST	Histamine H1 receptor inverse agonist	4
CHLORPHENOXAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LEVOCABASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIBENZEPIN	HRH1	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4
TISOTUMAB VEDOTIN	F3	Antibody	BINDING AGENT	Coagulation factor III binding agent	4
PROMETHAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZELASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE CITRATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TOLAZOLINE	HRH1	Small molecule	ANTAGONIST	Adrenergic receptor alpha antagonist	4
METHYLPROMAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZELASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ANTAZOLINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYCLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
FEXOFENADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DOXYLAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CETIRIZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENYLPYRALINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ESMIRTAZAPINE MALEATE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3
LEVOCETIRIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACRIVASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BEPOTASTINE BESYLATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
THENALIDINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIMENHYDRINATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
GSK-1004723	HRH1	Small molecule	ANTAGONIST	Histamine H3 receptor antagonist	2
PYRILAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
DEXCHLORPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYPROHEPTADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
PHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CLEMASTINE FUMARATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TOPIRAMATE	CA4	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4
VANTICTUMAB	FZD5	Antibody	ANTAGONIST	Frizzled-1 antagonist	1
BROMODIPHENHYDRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIMETHINDENE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ESMIRTAZAPINE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3
BROMPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MECLIZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHAPYRILENE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EMEDASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MIZOLASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
HYDROXYZINE PAMOATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ALCAFTADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACETAZOLAMIDE SODIUM	CA4	Small molecule	INHIBITOR	Carbonic anhydrase XII inhibitor	4
BETAHISTINE	HRH1	Small molecule	AGONIST	Histamine H1 receptor agonist	4
CARBINOXAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DESLORATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
POLMACOXIB	PTGS2	Small molecule	INHIBITOR	Carbonic anhydrase I inhibitor	3
ROCURONIUM	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
CETIRIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHDILAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DAVALINTIDE	RAMP1	Protein	AGONIST	Calcitonin gene-related peptide type 1 receptor agonist	2

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1848

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-02295	ERG	down-regulates	FOXL1	represses	R-1848	25	3	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-03731	DSP	down-regulates	FOXL1	represses	R-1848	25	17	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-04826	NEFM	down-regulates	FOXL1	represses	R-1848	25	7	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-23173	RNF17	down-regulates	FOXL1	represses	R-1848	25	4	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-24291	SMCHD1	down-regulates	FOXL1	represses	R-1848	25	4	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-24449	SEMA3C	up-regulates	FOXL1	represses	R-1848	25	9	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-26421	SPAG5	down-regulates	FOXL1	represses	R-1848	25	4	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE
CMF-29764	SLC5A7	down-regulates	FOXL1	represses	R-1848	25	6	Drugs (110) Regulator Drugs (0) Regulon Drugs (110) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, PRAMLINTIDE, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE, DAVALINTIDE

Regulon: R-1848

Regulon Summary

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Causal Flows

Causal Mechanistic Flows for Regulon R-1848

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