Regulon

Regulon: R-158

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
642.05931159Pr-7Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
2268 ENSG00000000938 FGR P09769
5329 ENSG00000011422 PLAUR Q03405
972 ENSG00000019582 CD74 P04233
864 ENSG00000020633 RUNX3 Q13761
3459 ENSG00000027697 IFNGR1 A0A2R8Y4U4
4481 ENSG00000038945 MSR1 P21757
6916 ENSG00000059377 TBXAS1 P24557
64778 ENSG00000075420 FNDC3B Q53EP0
55843 ENSG00000075884 ARHGAP15 Q53QZ3
3566 ENSG00000077238 IL4R P24394
5996 ENSG00000090104 RGS1 Q08116
3912 ENSG00000091136 LAMB1 P07942
4627 ENSG00000100345 MYH9 P35579
25939 ENSG00000101347 SAMHD1 Q9Y3Z3
945 ENSG00000105383 CD33 P20138
22797 ENSG00000105967 TFEC O14948
9404 ENSG00000110031 LPXN O60711
51411 ENSG00000110934 BIN2 Q9UBW5
397 ENSG00000111348 ARHGDIB P52566
5777 ENSG00000111679 PTPN6 P29350
202 ENSG00000112297 AIM1 Q96QW7
2335 ENSG00000115414 FN1 P02751
56944 ENSG00000116774 OLFML3 Q9NRN5
5552 ENSG00000122862 SRGN P10124
1236 ENSG00000126353 CCR7 P32248
10095 ENSG00000130429 ARPC1B O15143
241 ENSG00000132965 ALOX5AP P20292
474344 ENSG00000133561 GIMAP6 B4DH95
55303 ENSG00000133574 GIMAP4 A0A090N7X0
11309 ENSG00000137491 SLCO2B1 A0A1B0GX35
83478 ENSG00000138639 ARHGAP24 Q8N264
11010 ENSG00000139278 GLIPR1 B4E3S5
8477 ENSG00000140030 GPR65 Q8IYL9
963 ENSG00000143119 CD53 P19397
6001 ENSG00000148908 RGS10 O43665
64092 ENSG00000155307 SAMSN1 Q9NSI8
3570 ENSG00000160712 IL6R P08887
1234 ENSG00000160791 CCR5 P51681
3678 ENSG00000161638 ITGA5 P08648
7805 ENSG00000162511 LAPTM5 Q13571
25903 ENSG00000162745 OLFML2B Q68BL8
5966 ENSG00000162924 REL Q04864
7048 ENSG00000163513 TGFBR2 A3QNQ0
5724 ENSG00000169403 PTAFR P25105
929 ENSG00000170458 CD14 P08571
5293 ENSG00000171608 PIK3CD O00329
719 ENSG00000171860 C3AR1 Q16581
7096 ENSG00000174125 TLR1 Q15399
2 ENSG00000175899 A2M P01023
2885 ENSG00000177885 GRB2 P62993
3059 ENSG00000180353 HCLS1 P14317
10320 ENSG00000185811 IKZF1 Q13422
2124 ENSG00000185862 EVI2B P34910
51284 ENSG00000196664 TLR7 Q9NYK1
2760 ENSG00000196743 GM2A P17900
5660 ENSG00000197746 PSAP P07602
4668 ENSG00000198951 NAGA P17050
3119 ENSG00000233209 HLA-DQB1 Q5SU54
9936 ENSG00000241399 CD302 Q8IX05
1050 ENSG00000245848 CEBPA P49715
5788 ENSG00000262418 PTPRC P08575
10628 ENSG00000265972 TXNIP Q9H3M7
11024 ENSG00000277398 LILRA1 O75019
140 ENSG00000282608 ADORA3 P0DMS8

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
PF-04691502PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
PICOTAMIDETBXAS1Small moleculeINHIBITORThromboxane-A synthase inhibitor40
UMBRALISIBPIK3CDSmall moleculeINHIBITORTyrosine-protein kinase ABL inhibitor40
FIBOFLAPON SODIUMALOX5APSmall moleculeINHIBITOR5-lipoxygenase activating protein inhibitor30
ATN-161ITGB3ProteinANTAGONISTIntegrin alpha-5/beta-1 antagonist20
BGT-226PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
SONOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
RUPATADINEPTAFRSmall moleculeANTAGONISTPlatelet activating factor receptor antagonist30
HYDROXYCHLOROQUINETLR7Small moleculeANTAGONISTToll-like receptor 7 antagonist42
TERBOGRELTBXA2RSmall moleculeINHIBITORThromboxane-A synthase inhibitor20
PARSACLISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor30
INTERFERON GAMMA-1BIFNGR1ProteinAGONISTInterferon gamma receptor agonist40
VOXTALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor21
CINTREDEKIN BESUDOTOXIL4RProteinBINDING AGENTInterleukin 13 receptor binding agent33
PICLIDENOSONADORA3Small moleculeAGONISTAdenosine A3 receptor agonist30
NEMIRALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
RP-6530PIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor10
APITOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
DASATINIBABL1Small moleculeINHIBITORPlatelet-derived growth factor receptor beta inhibitor42
DS-7423PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
GSK-2269557PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
L19IL2FN1AntibodyBINDING AGENTFibronectin binding agent30
INCB-40093PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
PAXALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
AS-1409FN1AntibodyBINDING AGENTFibronectin binding agent10
PICTILISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
CCR5MAB004CCR5AntibodyINHIBITORC-C chemokine receptor type 5 inhibitor10
VICRIVIROCCCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist30
CAFFEINE, CITRATEDADORA1Small moleculeANTAGONISTAdenosine receptor antagonist40
TG100-115PIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor20
VS-5584PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
COPANLISIBPIK3CASmall moleculeINHIBITORPI3-kinase p110-alpha subunit inhibitor40
SAMOTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
AVE-9633CD33AntibodyBINDING AGENTMyeloid cell surface antigen CD33 binding agent10
VOBARILIZUMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor20
VESATOLIMODTLR7Small moleculeACTIVATORToll-like receptor 7 activator20
DUVELISIBPIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor40
L19TNFAFN1AntibodyBINDING AGENTFibronectin binding agent20
APLAVIROCCCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist30
MARAVIROCCCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist40
AZD-8848TLR7Small moleculeAGONISTToll-like receptor 7 agonist20
DACTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor30
ZANDELISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor30
TOCILIZUMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor42
AZD-8186PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor10
GNF-Pf-5468PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
WX-037PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
LERONLIMABCCR5AntibodyANTAGONISTC-C chemokine receptor type 5 antagonist30
PILARALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor21
ILORASERTIBPDGFRBSmall moleculeINHIBITORSerine/threonine-protein kinase Aurora inhibitor20
PREXIGEBERSENGRB2OligonucleotideANTISENSE INHIBITORGrowth factor receptor-bound protein 2 mRNA antisense inhibitor20
TASELISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor30
L19SIP 131IFN1AntibodyOTHERFibronectin other20
AMG-319PIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
HYDROXYCHLOROQUINE SULFATETLR7Small moleculeANTAGONISTToll-like receptor 7 antagonist40
HGS-1025CCR5AntibodyINHIBITORC-C chemokine receptor type 5 inhibitor10
COPANLISIB HYDROCHLORIDEPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor40
TENALISIBPIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor20
SELETALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
PF-04605412ITGA5AntibodyINHIBITORFibronectin receptor alpha inhibitor10
GEDATOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
OMIPALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
SARILUMABIL6RAntibodyANTAGONISTInterleukin-6 receptor alpha subunit antagonist40
UMBRALISIB TOSYLATECSNK1ESmall moleculeINHIBITORTyrosine-protein kinase ABL inhibitor40
GEMTUZUMABCD33AntibodyBINDING AGENTMyeloid cell surface antigen CD33 binding agent30
CENICRIVIROCCCR2Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist30
IDELALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor40
APLAVIROC HYDROCHLORIDECCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist30
XL-228ABL1Small moleculeINHIBITORTyrosine-protein kinase ABL inhibitor10
FIMEPINOSTATPIK3CDSmall moleculeINHIBITORPI3-kinase p110-alpha subunit inhibitor20
SATRALIZUMABIL6RAntibodyANTAGONISTIL6Ralpha/GP130 antagonist40
CPG-52852TLR7Small moleculeAGONISTToll-like receptor 7 agonist20
IMIQUIMODTLR7Small moleculeAGONISTToll-like receptor 7 agonist41
IC14CD14AntibodyINHIBITORMonocyte differentiation antigen CD14 inhibitor20
CAFFEINEADORA1Small moleculeANTAGONISTAdenosine receptor antagonist40
BMS-813160CCR5Small moleculeANTAGONISTC-C chemokine receptor type 2 antagonist20
GEMTUZUMAB OZOGAMICINCD33AntibodyBINDING AGENTMyeloid cell surface antigen CD33 binding agent40
PF-04634817CCR5Small moleculeANTAGONISTC-C chemokine receptor type 2 antagonist20
TG100-801EPHB4Small moleculeINHIBITORSRC inhibitor20
INCB-9471CCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist20
VICRIVIROC MALEATECCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist30
ADENOSINEADORA1Small moleculeAGONISTAdenosine receptor agonist40
VB-201CD14Small moleculeINHIBITORToll-like receptor 2 inhibitor20
DUPILUMABIL4RAntibodyANTAGONISTInterleukin-4 receptor subunit alpha antagonist40
ACALISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
PF-232798CCR5Small moleculeINHIBITORC-C chemokine receptor type 5 inhibitor20
GSK-2245035TLR7Small moleculeAGONISTToll-like receptor 7 agonist20
VELIFLAPONALOX5APSmall moleculeINHIBITOR5-lipoxygenase activating protein inhibitor30
TELRATOLIMODTLR8Small moleculeAGONISTToll-like receptor 8 agonist10
AZD5672CCR5Small moleculeANTAGONISTC-C chemokine receptor type 5 antagonist20
OCRIPLASMINLAMA2EnzymePROTEOLYTIC ENZYMEFibronectin proteolytic enzyme40
CAL-263PIK3CGSmall moleculeINHIBITORPI3-kinase p110-gamma subunit inhibitor10
OXTRIPHYLLINEPDE4ASmall moleculeINHIBITORPhosphodiesterase 3 inhibitor40
MILATUZUMABCD74AntibodyANTAGONISTHLA-DR antigens-associated invariant chain antagonist20
VOLOCIXIMABITGB1AntibodyANTAGONISTIntegrin alpha-5/beta-1 antagonist30
NAMODENOSONADORA3Small moleculeAGONISTAdenosine A3 receptor agonist20
LENIOLISIBPIK3CDSmall moleculeINHIBITORPI3-kinase p110-delta subunit inhibitor20
OZAGRELTBXAS1Small moleculeINHIBITORThromboxane-A synthase inhibitor30
PA-799PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
LINTUZUMABCD33AntibodyOTHERMyeloid cell surface antigen CD33 other30
LEVILIMABIL6RAntibodyINHIBITORInterleukin-6 receptor alpha subunit inhibitor30
GSK-1059615PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
BUPARLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor32
THEOPHYLLINEADORA1Small moleculeINHIBITORPhosphodiesterase 3 inhibitor40
SF-1126PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
AMINOPHYLLINEPDE3ASmall moleculeINHIBITORPhosphodiesterase 3 inhibitor40
FIBOFLAPONALOX5APSmall moleculeINHIBITOR5-lipoxygenase activating protein inhibitor30
ENMD-981693PDGFRBSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor20
PANULISIBACVRL1Small moleculeINHIBITORSerine/threonine-protein kinase receptor R3 inhibitor10
NELFINAVIRABCB1Small moleculeSUBSTRATE/INDUCER/INHIBITOREnergy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells, drugbank00

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-158

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-13818ADAMTS8down-regulatesARID5AactivatesR-158156Drugs (110)
CMF-15768MED12down-regulatesARID5AactivatesR-158153Drugs (110)
CMF-15950KCNB2up-regulatesARID5AactivatesR-158152Drugs (110)
CMF-18015PRPF40Bdown-regulatesARID5AactivatesR-158158Drugs (110)
CMF-18828SLFN13up-regulatesARID5AactivatesR-158153Drugs (110)
CMF-23852TP53down-regulatesARID5AactivatesR-158159Drugs (110)
CMF-24247OR5D18down-regulatesARID5AactivatesR-158151Drugs (110)
CMF-27630ANKRD36up-regulatesARID5AactivatesR-158153Drugs (110)
CMF-30343FAM75C1down-regulatesARID5AactivatesR-158151Drugs (110)
CMF-33873ZNF292up-regulateshsa-mir-125brepressesR-158108Drugs (110)
CMF-33880SKAP2down-regulateshsa-mir-328repressesR-158277Drugs (110)
CMF-33915SDPRdown-regulateshsa-mir-328repressesR-158273Drugs (110)
CMF-34850NEBdown-regulateshsa-mir-328repressesR-158275Drugs (110)
CMF-35099HTR5Adown-regulateshsa-mir-328repressesR-158275Drugs (110)
CMF-35952AHNAK2up-regulateshsa-mir-25repressesR-15822Drugs (110)
CMF-35960AHNAK2up-regulateshsa-mir-125brepressesR-158105Drugs (110)
CMF-35981AHNAK2up-regulateshsa-mir-95repressesR-158735Drugs (110)
CMF-36126TNK2up-regulateshsa-mir-125brepressesR-158107Drugs (110)
CMF-36141TNK2up-regulateshsa-mir-17-3prepressesR-1585240Drugs (110)
CMF-36241TRIM6-TRIM34up-regulateshsa-mir-125brepressesR-158105Drugs (110)
CMF-36262KIF4Aup-regulateshsa-mir-130brepressesR-15896Drugs (110)
CMF-36707ATP8A2up-regulateshsa-mir-25repressesR-15822Drugs (110)
CMF-36717ATP8A2up-regulateshsa-mir-17-3prepressesR-1585240Drugs (110)
CMF-37163CYP4F22down-regulateshsa-mir-7repressesR-1581817Drugs (110)
CMF-37394ABCA10down-regulateshsa-mir-95repressesR-158737Drugs (110)
CMF-37684ADAMTS8up-regulateshsa-mir-17-3prepressesR-1585240Drugs (110)
CMF-37841PRKCDup-regulateshsa-mir-328repressesR-1582722Drugs (110)
CMF-37862PRKCDup-regulateshsa-mir-130brepressesR-15896Drugs (110)
CMF-37911C1orf177down-regulateshsa-mir-551brepressesR-158225Drugs (110)
CMF-37951COL6A2down-regulateshsa-mir-17-3prepressesR-1585217Drugs (110)
CMF-38022PPEF2down-regulateshsa-mir-551brepressesR-158223Drugs (110)
CMF-38071OR51F1up-regulateshsa-mir-551brepressesR-158225Drugs (110)
CMF-38076OR51F1up-regulateshsa-mir-25repressesR-15822Drugs (110)
CMF-38399KCNB2down-regulateshsa-mir-551brepressesR-158225Drugs (110)
CMF-38438KCNB2down-regulateshsa-mir-17-3prepressesR-1585236Drugs (110)
CMF-38513NFIXdown-regulateshsa-mir-328repressesR-158277Drugs (110)
CMF-38959PRPF40Bup-regulateshsa-mir-125brepressesR-1581010Drugs (110)
CMF-39097DNMBPdown-regulateshsa-mir-328repressesR-158276Drugs (110)
CMF-39127DNMBPdown-regulateshsa-mir-17-3prepressesR-1585235Drugs (110)
CMF-39277SLFN13down-regulateshsa-mir-328repressesR-158273Drugs (110)
CMF-39281SLFN13down-regulateshsa-mir-488repressesR-158196Drugs (110)
CMF-39319INPP5Jup-regulateshsa-mir-488repressesR-1581910Drugs (110)
CMF-39360UPF1down-regulateshsa-mir-328repressesR-158272Drugs (110)
CMF-39484NF1down-regulateshsa-mir-551brepressesR-1582218Drugs (110)
CMF-39528NF1down-regulateshsa-mir-488repressesR-1581912Drugs (110)
CMF-39542NF1down-regulateshsa-mir-125brepressesR-158109Drugs (110)
CMF-39572NF1down-regulateshsa-mir-95repressesR-1587347Drugs (110)
CMF-39759RPSAP58down-regulateshsa-mir-17-3prepressesR-1585240Drugs (110)
CMF-39815UGT2B4down-regulateshsa-mir-149repressesR-1585135Drugs (110)
CMF-39950TDRD9down-regulateshsa-mir-17-3prepressesR-1585242Drugs (110)
CMF-40315MUC17down-regulateshsa-mir-125brepressesR-158109Drugs (110)
CMF-41242TP53up-regulateshsa-mir-551brepressesR-1582214Drugs (110)
CMF-41255TP53up-regulateshsa-mir-25repressesR-15822Drugs (110)
CMF-41321TP53up-regulateshsa-mir-17-3prepressesR-1585252Drugs (110)
CMF-42160NAALADL1down-regulateshsa-mir-328repressesR-158277Drugs (110)
CMF-42338SDK1down-regulateshsa-mir-328repressesR-158276Drugs (110)
CMF-42347SDK1down-regulateshsa-mir-7repressesR-1581814Drugs (110)
CMF-42384KRTAP20-2down-regulateshsa-mir-7repressesR-1581815Drugs (110)
CMF-43256SALL4up-regulateshsa-mir-125brepressesR-158106Drugs (110)