Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation THADA_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-24581 | THADA | down-regulates | STAT3 | activates | R-1527 | 25 | 5 | Drugs (3) |
| CMF-24584 | THADA | down-regulates | STAT3 | activates | R-1539 | 25 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24590 | THADA | down-regulates | LEF1 | activates | R-1425 | 18 | 2 | Drugs (2) |
| CMF-24593 | THADA | down-regulates | MAF | activates | R-179 | 19 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-24594 | THADA | down-regulates | RORA | activates | R-1949 | 8 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24595 | THADA | down-regulates | IRF1 | activates | R-118 | 25 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-24598 | THADA | down-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-24599 | THADA | down-regulates | MEOX2 | activates | R-2196 | 14 | 4 | Drugs (1) |
| CMF-24601 | THADA | down-regulates | MEOX2 | activates | R-2202 | 14 | 4 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT |
| CMF-24604 | THADA | down-regulates | HMGA2 | activates | R-3604 | 2 | 1 | Drugs (1) |
| CMF-24605 | THADA | down-regulates | ELF4 | activates | R-3010 | 20 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)SULTHIAME, CILENGITIDE, SENICAPOC, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, ABITUZUMAB |
| CMF-24609 | THADA | down-regulates | KLF4 | activates | R-2122 | 10 | 6 | Drugs (2) |
| CMF-24611 | THADA | down-regulates | KLF4 | activates | R-2120 | 10 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24612 | THADA | down-regulates | KLF4 | activates | R-2116 | 10 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24613 | THADA | down-regulates | KLF4 | activates | R-2115 | 10 | 6 | Drugs (2) |
| CMF-41615 | THADA | up-regulates | hsa-mir-93 | represses | R-378 | 44 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-41616 | THADA | up-regulates | hsa-mir-93 | represses | R-998 | 44 | 2 | Drugs (5) |