Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation SLC4A7_code_potential_somatic

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-08625	SLC4A7	down-regulates	POU3F3	represses	R-2622	19	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-08630	SLC4A7	down-regulates	FOXD3	represses	R-576	25	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-08632	SLC4A7	up-regulates	NR3C1	activates	R-2033	21	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08634	SLC4A7	up-regulates	NR3C1	activates	R-2047	21	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08636	SLC4A7	down-regulates	FEV	represses	R-3031	5	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) TAS0612, OCRIPLASMIN
CMF-08640	SLC4A7	up-regulates	FOXC1	activates	R-663	20	3	Drugs (61) Regulator Drugs (0) Regulon Drugs (61) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, CUSATUZUMAB, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, VORSETUZUMAB MAFODOTIN, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, MDX-1411, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, LAROTAXEL, RG-7841, LORVOTUZUMAB MERTANSINE
CMF-08642	SLC4A7	up-regulates	PRRX1	activates	R-3072	18	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) TAS0612, OCRIPLASMIN
CMF-08643	SLC4A7	down-regulates	HOXB13	represses	R-3231	15	5	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-08651	SLC4A7	down-regulates	GBX2	represses	R-2078	7	1	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-08654	SLC4A7	down-regulates	HNF1A	represses	R-1788	18	3	Drugs (10) Regulator Drugs (0) Regulon Drugs (10) RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT
CMF-36322	SLC4A7	down-regulates	hsa-mir-328	represses	R-152	27	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) MARIMASTAT
CMF-36323	SLC4A7	down-regulates	hsa-mir-328	represses	R-227	27	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-36324	SLC4A7	down-regulates	hsa-mir-328	represses	R-2441	27	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-36325	SLC4A7	down-regulates	hsa-mir-328	represses	R-1047	27	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-36326	SLC4A7	down-regulates	hsa-mir-328	represses	R-3143	27	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-36327	SLC4A7	down-regulates	hsa-mir-328	represses	R-1890	27	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN
CMF-36328	SLC4A7	down-regulates	hsa-mir-326	represses	R-218	16	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36329	SLC4A7	down-regulates	hsa-mir-326	represses	R-2459	16	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36330	SLC4A7	down-regulates	hsa-mir-326	represses	R-2760	16	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36331	SLC4A7	down-regulates	hsa-mir-326	represses	R-2892	16	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36332	SLC4A7	down-regulates	hsa-mir-326	represses	R-2950	16	6	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36333	SLC4A7	down-regulates	hsa-mir-326	represses	R-1546	16	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) OCRIPLASMIN
CMF-36334	SLC4A7	down-regulates	hsa-mir-375	represses	R-218	61	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36335	SLC4A7	down-regulates	hsa-mir-375	represses	R-2459	61	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36336	SLC4A7	down-regulates	hsa-mir-375	represses	R-2892	61	5	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB
CMF-36337	SLC4A7	down-regulates	hsa-mir-375	represses	R-1546	61	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) OCRIPLASMIN
CMF-36338	SLC4A7	down-regulates	hsa-mir-375	represses	R-1949	61	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

Causal Mechanistic Flows regulated by Mutation SLC4A7_code_potential_somatic

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Regulon Drugs (8)

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Regulon Drugs (61)

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