Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation SCN1A_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03502 | SCN1A | down-regulates | LHX1 | represses | R-2964 | 17 | 3 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-03504 | SCN1A | down-regulates | LHX1 | represses | R-2971 | 17 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03509 | SCN1A | up-regulates | SOX9 | activates | R-1225 | 16 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-03510 | SCN1A | up-regulates | MEOX2 | activates | R-2195 | 14 | 2 | Drugs (24) Regulator Drugs (0)Regulon Drugs (24)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-03511 | SCN1A | up-regulates | MEOX2 | activates | R-2203 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03512 | SCN1A | up-regulates | HLX | activates | R-3583 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03513 | SCN1A | up-regulates | HLX | activates | R-3588 | 10 | 2 | Drugs (1) |
| CMF-03515 | SCN1A | down-regulates | GATA2 | represses | R-1802 | 4 | 2 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE |
| CMF-34476 | SCN1A | down-regulates | hsa-mir-375 | represses | R-2843 | 61 | 6 | Drugs (2) |
| CMF-34477 | SCN1A | down-regulates | hsa-mir-375 | represses | R-2892 | 61 | 6 | Drugs (3) |
| CMF-34478 | SCN1A | down-regulates | hsa-mir-375 | represses | R-1140 | 61 | 6 | Drugs (1) |
| CMF-34479 | SCN1A | down-regulates | hsa-mir-375 | represses | R-1546 | 61 | 6 | Drugs (1) |
| CMF-34480 | SCN1A | down-regulates | hsa-mir-375 | represses | R-1949 | 61 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34481 | SCN1A | down-regulates | hsa-mir-375 | represses | R-2029 | 61 | 6 | Drugs (1) |