Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation RAD51AP2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-11747 | RAD51AP2 | up-regulates | NR3C1 | activates | R-2051 | 21 | 1 | Drugs (1) |
| CMF-11750 | RAD51AP2 | down-regulates | STAT4 | represses | R-1147 | 16 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11752 | RAD51AP2 | up-regulates | EP300 | activates | R-3413 | 5 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11754 | RAD51AP2 | up-regulates | SOX9 | activates | R-1227 | 16 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11756 | RAD51AP2 | down-regulates | SIX6 | represses | R-3176 | 4 | 1 | Drugs (4) |
| CMF-11766 | RAD51AP2 | up-regulates | POU3F2 | activates | R-2175 | 17 | 4 | Drugs (1) |
| CMF-37248 | RAD51AP2 | down-regulates | hsa-mir-490 | represses | R-3475 | 35 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37249 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2051 | 155 | 17 | Drugs (1) |
| CMF-37250 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2175 | 155 | 17 | Drugs (1) |
| CMF-37251 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2202 | 155 | 17 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT |
| CMF-37252 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2465 | 155 | 17 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-37253 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2492 | 155 | 17 | Drugs (1) |
| CMF-37254 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2652 | 155 | 17 | Drugs (1) |
| CMF-37255 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-635 | 155 | 17 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-37256 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-752 | 155 | 17 | Drugs (1) |
| CMF-37257 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-812 | 155 | 17 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37258 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-1138 | 155 | 17 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-37259 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-1140 | 155 | 17 | Drugs (1) |
| CMF-37260 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-1294 | 155 | 17 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT |
| CMF-37261 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-3475 | 155 | 17 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37262 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-3707 | 155 | 17 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT |
| CMF-37263 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-1882 | 155 | 17 | Drugs (1) |
| CMF-37264 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-1916 | 155 | 17 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-37265 | RAD51AP2 | down-regulates | hsa-mir-129 | represses | R-2029 | 155 | 17 | Drugs (1) |