Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation PRKCD_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-14471PRKCDup-regulatesPOU3F3repressesR-2623192Drugs (92)
CMF-14474PRKCDdown-regulatesFOXO1activatesR-704213Drugs (24)
CMF-14476PRKCDdown-regulatesFOXO1activatesR-710213Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14477PRKCDdown-regulatesSREBF1activatesR-2507125Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

TOSEDOSTAT

CMF-14478PRKCDdown-regulatesSREBF1activatesR-2503125Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14479PRKCDdown-regulatesSREBF1activatesR-2500125Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14480PRKCDdown-regulatesSREBF1activatesR-2501125Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14481PRKCDdown-regulatesSREBF1activatesR-2498125Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, NATALIZUMAB, FIRATEGRAST, VOLOCIXIMAB, ABITUZUMAB

CMF-14482PRKCDdown-regulatesEGR1activatesR-991204Drugs (9)
CMF-14483PRKCDdown-regulatesEGR1activatesR-1006204Drugs (8)
CMF-14484PRKCDdown-regulatesEGR1activatesR-998204Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST

CMF-14485PRKCDdown-regulatesEGR1activatesR-996204Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

OCRIPLASMIN, GSK-690693

CMF-14491PRKCDdown-regulatesFOSL1activatesR-1985124Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN

CMF-14492PRKCDdown-regulatesFOSL1activatesR-1993124Drugs (58)
CMF-14493PRKCDdown-regulatesFOSL1activatesR-1984124Drugs (7)
CMF-14494PRKCDdown-regulatesFOSL1activatesR-1982124Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN

CMF-14496PRKCDdown-regulatesGATA6activatesR-1258183Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14497PRKCDdown-regulatesFOSactivatesR-339961Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

SULTHIAME, BIVATUZUMAB

CMF-14501PRKCDdown-regulatesMAXactivatesR-3503184Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

ABRILUMAB, NATALIZUMAB, FIRATEGRAST, VEDOLIZUMAB

CMF-14502PRKCDdown-regulatesMAXactivatesR-3493184Drugs (21)
CMF-14503PRKCDdown-regulatesMAXactivatesR-3491184Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, FRESOLIMUMAB

CMF-14505PRKCDdown-regulatesGATA3activatesR-309672Drugs (8)
CMF-14507PRKCDdown-regulatesSTAT6activatesR-2279114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DIQUAFOSOL, DIQUAFOSOL TETRASODIUM

CMF-14508PRKCDdown-regulatesSTAT6activatesR-2281114Drugs (8)
CMF-14510PRKCDdown-regulatesSTAT6activatesR-2280114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DANVATIRSEN, CARLUMAB

CMF-14512PRKCDdown-regulatesFLI1activatesR-3265112Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

RILOTUMUMAB, FICLATUZUMAB

CMF-37840PRKCDup-regulateshsa-mir-328repressesR-1522722Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

MARIMASTAT

CMF-37841PRKCDup-regulateshsa-mir-328repressesR-1582722Drugs (110)
CMF-37842PRKCDup-regulateshsa-mir-328repressesR-2272722Drugs (9)
CMF-37843PRKCDup-regulateshsa-mir-328repressesR-2462722Drugs (63)
CMF-37844PRKCDup-regulateshsa-mir-328repressesR-2572722Drugs (149)

Regulator Drugs (0)

Regulon Drugs (149)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, NEMIRALISIB, RP-6530, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, PEGSUNERCEPT, GOLIMUMAB, VICRIVIROC, CAFFEINE, CITRATED, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, L19TNFA, APLAVIROC, MARAVIROC, AZD-8848, DACTOLISIB, BOSUTINIB, BAFETINIB, ZANDELISIB, HMPL-523, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, CPG-52852, SELGANTOLIMOD, R-333, IMIQUIMOD, GUSACITINIB, REMTOLUMAB, TOLIMIDONE, CAFFEINE, MOTOLIMOD, TOMIVOSERTIB, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, ADENOSINE, DUPILUMAB, ACALISIB, PF-232798, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, AZD5672, OCRIPLASMIN, CAL-263, OXTRIPHYLLINE, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, NAMODENOSON, LENIOLISIB, OZAGREL, PA-799, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, GSK-690693, THEOPHYLLINE, SF-1126, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-37845PRKCDup-regulateshsa-mir-328repressesR-2902722Drugs (110)
CMF-37846PRKCDup-regulateshsa-mir-328repressesR-3562722Drugs (108)
CMF-37847PRKCDup-regulateshsa-mir-328repressesR-24412722Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

MARIMASTAT, TOSEDOSTAT

CMF-37848PRKCDup-regulateshsa-mir-328repressesR-10062722Drugs (8)
CMF-37849PRKCDup-regulateshsa-mir-328repressesR-10472722Drugs (9)
CMF-37850PRKCDup-regulateshsa-mir-328repressesR-17342722Drugs (8)
CMF-37851PRKCDup-regulateshsa-mir-328repressesR-37892722Drugs (8)
CMF-37852PRKCDup-regulateshsa-mir-328repressesR-20432722Drugs (8)
CMF-37853PRKCDup-regulateshsa-mir-328repressesR-1572722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37854PRKCDup-regulateshsa-mir-328repressesR-2452722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37855PRKCDup-regulateshsa-mir-328repressesR-26012722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37856PRKCDup-regulateshsa-mir-328repressesR-27652722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37857PRKCDup-regulateshsa-mir-328repressesR-29452722Drugs (7)
CMF-37858PRKCDup-regulateshsa-mir-328repressesR-30292722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37859PRKCDup-regulateshsa-mir-328repressesR-31312722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37860PRKCDup-regulateshsa-mir-328repressesR-35712722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37861PRKCDup-regulateshsa-mir-328repressesR-18952722Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, ALEPLASININ, BRENSOCATIB, PF-04605412, VOLOCIXIMAB

CMF-37862PRKCDup-regulateshsa-mir-130brepressesR-15896Drugs (110)
CMF-37863PRKCDup-regulateshsa-mir-130brepressesR-24696Drugs (63)
CMF-37864PRKCDup-regulateshsa-mir-130brepressesR-25796Drugs (149)

Regulator Drugs (0)

Regulon Drugs (149)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, NEMIRALISIB, RP-6530, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, PEGSUNERCEPT, GOLIMUMAB, VICRIVIROC, CAFFEINE, CITRATED, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, L19TNFA, APLAVIROC, MARAVIROC, AZD-8848, DACTOLISIB, BOSUTINIB, BAFETINIB, ZANDELISIB, HMPL-523, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, CPG-52852, SELGANTOLIMOD, R-333, IMIQUIMOD, GUSACITINIB, REMTOLUMAB, TOLIMIDONE, CAFFEINE, MOTOLIMOD, TOMIVOSERTIB, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, ADENOSINE, DUPILUMAB, ACALISIB, PF-232798, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, AZD5672, OCRIPLASMIN, CAL-263, OXTRIPHYLLINE, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, NAMODENOSON, LENIOLISIB, OZAGREL, PA-799, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, GSK-690693, THEOPHYLLINE, SF-1126, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-37865PRKCDup-regulateshsa-mir-130brepressesR-29096Drugs (110)
CMF-37866PRKCDup-regulateshsa-mir-130brepressesR-35696Drugs (108)
CMF-37867PRKCDup-regulateshsa-mir-130brepressesR-275996Drugs (9)
CMF-37868PRKCDup-regulateshsa-mir-641repressesR-8686Drugs (43)
CMF-37869PRKCDup-regulateshsa-mir-641repressesR-19286Drugs (56)
CMF-37870PRKCDup-regulateshsa-mir-641repressesR-23286Drugs (60)
CMF-37871PRKCDup-regulateshsa-mir-641repressesR-27586Drugs (29)
CMF-37872PRKCDup-regulateshsa-mir-641repressesR-35086Drugs (20)
CMF-37873PRKCDup-regulateshsa-mir-641repressesR-99886Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST