Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation OR8K3_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-25499 | OR8K3 | up-regulates | FOXO1 | activates | R-708 | 21 | 1 | Drugs (45) Regulator Drugs (0)Regulon Drugs (45)PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB |