Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation OR2M3_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03538 | OR2M3 | up-regulates | TP53 | activates | R-1781 | 13 | 2 | Drugs (32) Regulator Drugs (0)Regulon Drugs (32)PF-04691502, VACTOSERTIB, BGT-226, SONOLISIB, VOXTALISIB, RP-6530, APITOLISIB, DS-7423, PAXALISIB, PICTILISIB, TG100-115, VS-5584, SAMOTOLISIB, DUVELISIB, DACTOLISIB, GNF-Pf-5468, WX-037, PILARALISIB, TASELISIB, TENALISIB, GEDATOLISIB, OMIPALISIB, VERNAKALANT, VERNAKALANT HYDROCHLORIDE, CAL-263, RHIGM12B7, PA-799, GALUNISERTIB, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB |