Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation NBPF9_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-23305 | NBPF9 | up-regulates | IRF1 | activates | R-115 | 25 | 1 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-41175 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-171 | 58 | 22 | Drugs (2) |
| CMF-41176 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-189 | 58 | 22 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41177 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-274 | 58 | 22 | Drugs (2) |
| CMF-41178 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-307 | 58 | 22 | Drugs (2) |
| CMF-41179 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-411 | 58 | 22 | Drugs (2) |
| CMF-41180 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-2489 | 58 | 22 | Drugs (2) |
| CMF-41181 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-2605 | 58 | 22 | Drugs (2) |
| CMF-41182 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-3028 | 58 | 22 | Drugs (2) |
| CMF-41183 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-1091 | 58 | 22 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41184 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-1457 | 58 | 22 | Drugs (2) |
| CMF-41185 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-3695 | 58 | 22 | Drugs (2) |
| CMF-41186 | NBPF9 | down-regulates | hsa-mir-139 | represses | R-1847 | 58 | 22 | Drugs (2) |
| CMF-41187 | NBPF9 | up-regulates | hsa-mir-339 | represses | R-597 | 1 | 1 | Drugs (65) Regulator Drugs (0)Regulon Drugs (65)ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, PRALUZATAMAB RAVTANSINE, LADIRATUZUMAB VEDOTIN, PACLITAXEL, CROLIBULIN, PACLITAXEL POLIGLUMEX, PATUPILONE, ASG-5ME, ANG1005, PINATUZUMAB VEDOTIN, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DESFLURANE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, ABT-751, MIRVETUXIMAB SORAVTANSINE, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, PLITIDEPSIN, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, SAR-408701, CABAZITAXEL, PACLITAXEL DOCOSAHEXAENOIC ACID, ISOFLURANE, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, SEVOFLURANE, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, AZINTUXIZUMAB VEDOTIN, DOXAPRAM, DOXAPRAM HYDROCHLORIDE, LAROTAXEL, RG-7841, GSK-690693, LORVOTUZUMAB MERTANSINE |
| CMF-41188 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-171 | 13 | 12 | Drugs (2) |
| CMF-41189 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-189 | 13 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41190 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-274 | 13 | 12 | Drugs (2) |
| CMF-41191 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-307 | 13 | 12 | Drugs (2) |
| CMF-41192 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-411 | 13 | 12 | Drugs (2) |
| CMF-41193 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-2489 | 13 | 12 | Drugs (2) |
| CMF-41194 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-2605 | 13 | 12 | Drugs (2) |
| CMF-41195 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-3028 | 13 | 12 | Drugs (2) |
| CMF-41196 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-1091 | 13 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41197 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-1457 | 13 | 12 | Drugs (2) |
| CMF-41198 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-3695 | 13 | 12 | Drugs (2) |
| CMF-41199 | NBPF9 | down-regulates | hsa-mir-138 | represses | R-1847 | 13 | 12 | Drugs (2) |