Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation KIF4A_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-08235KIF4Adown-regulatesIRF2activatesR-417257Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

TOSEDOSTAT

CMF-08236KIF4Adown-regulatesIRF2activatesR-420257Drugs (6)
CMF-08237KIF4Adown-regulatesIRF2activatesR-418257Drugs (4)
CMF-08239KIF4Adown-regulatesIRF2activatesR-413257Drugs (139)

Regulator Drugs (0)

Regulon Drugs (139)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, UMBRALISIB, FIBOFLAPON SODIUM, ATN-161, BGT-226, SONOLISIB, CSL-324, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, R-348, PF-06651600, AMY-101, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, ABIVERTINIB MALEATE, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, EFALIZUMAB, DACTOLISIB, BOSUTINIB, FILGRASTIM, ZANDELISIB, HMPL-523, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, RO-5458640, TASELISIB, L19SIP 131I, AMG-319, IBRUTINIB, TADEKINIG ALFA, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, SELGANTOLIMOD, R-333, OTLERTUZUMAB, GUSACITINIB, BI-836826, MOTOLIMOD, TREGALIZUMAB, ERITORAN TETRASODIUM, TG100-801, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, LENOGRASTIM, POSELTINIB, LIFITEGRAST, VB-201, ACALISIB, ZANOLIMUMAB, MIVAVOTINIB CITRATE, VELIFLAPON, PIRTOBRUTINIB, TELRATOLIMOD, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, FOSTAMATINIB, TOMARALIMAB, ELSUBRUTINIB, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-08240KIF4Adown-regulatesIRF2activatesR-419257Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-08241KIF4Adown-regulatesIRF2activatesR-424257Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-08244KIF4Adown-regulatesNFKB1activatesR-298258Drugs (17)
CMF-08245KIF4Adown-regulatesNFKB1activatesR-300258Drugs (23)
CMF-08247KIF4Adown-regulatesNFKB1activatesR-294258Drugs (5)
CMF-08248KIF4Adown-regulatesNFKB1activatesR-292258Drugs (20)
CMF-08249KIF4Adown-regulatesNFKB1activatesR-290258Drugs (110)
CMF-08250KIF4Adown-regulatesNFKB1activatesR-299258Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-08251KIF4Aup-regulatesIKZF2repressesR-1886162Drugs (4)
CMF-08252KIF4Aup-regulatesIKZF2repressesR-1883162Drugs (107)

Regulator Drugs (0)

Regulon Drugs (107)

CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, GSK-1995057, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, TISOTUMAB VEDOTIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE

CMF-08253KIF4Adown-regulatesSREBF1activatesR-2503124Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08255KIF4Adown-regulatesSREBF1activatesR-2500124Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08256KIF4Adown-regulatesSREBF1activatesR-2498124Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, NATALIZUMAB, FIRATEGRAST, VOLOCIXIMAB, ABITUZUMAB

CMF-08257KIF4Adown-regulatesMAFactivatesR-185198Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

DANVATIRSEN

CMF-08258KIF4Adown-regulatesMAFactivatesR-174198Drugs (16)
CMF-08259KIF4Adown-regulatesMAFactivatesR-175198Drugs (4)
CMF-08260KIF4Adown-regulatesMAFactivatesR-173198Drugs (89)
CMF-08264KIF4Adown-regulatesMAFactivatesR-179198Drugs (6)
CMF-08265KIF4Adown-regulatesSPI1activatesR-375256Drugs (10)
CMF-08266KIF4Adown-regulatesSPI1activatesR-370256Drugs (199)

Regulator Drugs (0)

Regulon Drugs (199)

PF-04691502, LY-2787106, FOSTAMATINIB DISODIUM, PICOTAMIDE, SARGRAMOSTIM, UMBRALISIB, PAZOPANIB, MIDOSTAURIN, FIBOFLAPON SODIUM, ATN-161, BGT-226, SONOLISIB, RUPATADINE, CSL-324, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, SUNITINIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, PEXIDARTINIB HYDROCHLORIDE, PF-06651600, AMY-101, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, PAZOPANIB HYDROCHLORIDE, ABIVERTINIB MALEATE, VICRIVIROC, MEDI-2338, VATALANIB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, CAROTUXIMAB, L19TNFA, EDICOTINIB, APLAVIROC, MARAVIROC, AZD-8848, SUNITINIB MALATE, EFALIZUMAB, DACTOLISIB, BOSUTINIB, BAFETINIB, FILGRASTIM, ZANDELISIB, HMPL-523, PLX-7486, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, SOTRASTAURIN, PILARALISIB, ILORASERTIB, DAPANSUTRILE, ENMD-2076, RO-5458640, CCX354, PREXIGEBERSEN, AMG-820, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, IBRUTINIB, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, PLX-5622, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, ENTOLIMOD, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, AZD4818, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, CPG-52852, R-333, IMIQUIMOD, IC14, OTLERTUZUMAB, GUSACITINIB, BI-836826, TOLIMIDONE, MAVRILIMUMAB, TREGALIZUMAB, ERITORAN TETRASODIUM, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, VICRIVIROC MALEATE, LENOGRASTIM, POSELTINIB, PEXIDARTINIB, LIFITEGRAST, VB-201, QUIZARTINIB, ACALISIB, PF-232798, ZANOLIMUMAB, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, PIRTOBRUTINIB, TELRATOLIMOD, AZD5672, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, LINIFANIB, FOSTAMATINIB, ELSUBRUTINIB, IMC-CS4, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, ARRY-382, EMACTUZUMAB, LINTUZUMAB, TIRABRUTINIB, DELCASERTIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, ORELABRUTINIB, GSK-1070806, FIBOFLAPON, CABIRALIZUMAB, AL-78898A, ENMD-981693, PANULISIB, AXATILIMAB

CMF-08269KIF4Adown-regulatesSPI1activatesR-371256Drugs (31)
CMF-08272KIF4Adown-regulatesARID3AactivatesR-680196Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB

CMF-08275KIF4Adown-regulatesARID3AactivatesR-683196Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-08278KIF4Aup-regulatesPAX7repressesR-369831Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08282KIF4Adown-regulatesPRRX1activatesR-3071185Drugs (34)
CMF-08283KIF4Adown-regulatesPRRX1activatesR-3073185Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A

CMF-08285KIF4Adown-regulatesELK3activatesR-361021Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

TIGATUZUMAB, CONATUMUMAB, DULANERMIN, LEXATUMUMAB, DROZITUMAB

CMF-08287KIF4Adown-regulatesIKZF1activatesR-3137164Drugs (7)

Regulator Drugs (0)

Regulon Drugs (7)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN

CMF-08288KIF4Adown-regulatesIKZF1activatesR-3133164Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

CINTREDEKIN BESUDOTOX

CMF-08289KIF4Adown-regulatesIKZF1activatesR-3140164Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08290KIF4Adown-regulatesIKZF1activatesR-3138164Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-08291KIF4Adown-regulatesCEBPGactivatesR-1048233Drugs (13)
CMF-08292KIF4Adown-regulatesCEBPGactivatesR-1046233Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB

CMF-08296KIF4Aup-regulatesGBX2repressesR-208471Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08297KIF4Aup-regulatesMYCNrepressesR-180652Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NIVOCASAN, EMRICASAN

CMF-08298KIF4Aup-regulatesMYCNrepressesR-180752Drugs (5)
CMF-08300KIF4Adown-regulatesMAXactivatesR-3491182Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, FRESOLIMUMAB

CMF-08302KIF4Adown-regulatesRELactivatesR-24684Drugs (63)
CMF-08303KIF4Adown-regulatesRELactivatesR-25284Drugs (17)
CMF-08304KIF4Adown-regulatesRELactivatesR-24884Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DAVANAT, CINTREDEKIN BESUDOTOX

CMF-08309KIF4Adown-regulatesSTAT6activatesR-2287114Drugs (6)
CMF-08310KIF4Adown-regulatesSTAT6activatesR-2280114Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

DANVATIRSEN, CARLUMAB

CMF-08313KIF4Adown-regulatesSMAD1activatesR-1495214Drugs (7)
CMF-08315KIF4Aup-regulatesPOU6F2repressesR-2612122Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

ALEPLASININ, VESENCUMAB

CMF-08316KIF4Aup-regulatesPOU6F2repressesR-2616122Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-36262KIF4Aup-regulateshsa-mir-130brepressesR-15896Drugs (110)
CMF-36263KIF4Aup-regulateshsa-mir-130brepressesR-24696Drugs (63)
CMF-36264KIF4Aup-regulateshsa-mir-130brepressesR-25796Drugs (149)

Regulator Drugs (0)

Regulon Drugs (149)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, NEMIRALISIB, RP-6530, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, PEGSUNERCEPT, GOLIMUMAB, VICRIVIROC, CAFFEINE, CITRATED, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, L19TNFA, APLAVIROC, MARAVIROC, AZD-8848, DACTOLISIB, BOSUTINIB, BAFETINIB, ZANDELISIB, HMPL-523, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, CPG-52852, SELGANTOLIMOD, R-333, IMIQUIMOD, GUSACITINIB, REMTOLUMAB, TOLIMIDONE, CAFFEINE, MOTOLIMOD, TOMIVOSERTIB, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, ADENOSINE, DUPILUMAB, ACALISIB, PF-232798, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, AZD5672, OCRIPLASMIN, CAL-263, OXTRIPHYLLINE, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, NAMODENOSON, LENIOLISIB, OZAGREL, PA-799, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, GSK-690693, THEOPHYLLINE, SF-1126, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-36265KIF4Aup-regulateshsa-mir-130brepressesR-29096Drugs (110)
CMF-36266KIF4Aup-regulateshsa-mir-130brepressesR-35696Drugs (108)
CMF-36267KIF4Aup-regulateshsa-mir-130brepressesR-275996Drugs (9)