| CMF-20290 | FREM1 | up-regulates | NFKB1 | activates | R-297 | 25 | 3 | Drugs (6) |
| CMF-20293 | FREM1 | down-regulates | FOXD3 | represses | R-576 | 25 | 3 | Drugs (8) |
| CMF-20297 | FREM1 | up-regulates | SREBF1 | activates | R-2499 | 12 | 4 | Drugs (89) Regulator Drugs (0)Regulon Drugs (89)PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE |
| CMF-20301 | FREM1 | up-regulates | MAFG | activates | R-1510 | 13 | 3 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-20303 | FREM1 | down-regulates | FEV | represses | R-3030 | 5 | 2 | Drugs (71) Regulator Drugs (0)Regulon Drugs (71)ESTROGENS, ESTERIFIED, SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, RALOXIFENE, PRINABEREL, LASOFOXIFENE, AMUVATINIB, BAZEDOXIFENE ACETATE, CHLOROTRIANISENE, ESTRIOL, BIRINAPANT, ACOLBIFENE, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, SYNTHETIC CONJUGATED ESTROGENS, B, OSPEMIFENE, TEPOTINIB HYDROCHLORIDE, TOREMIFENE CITRATE, FORETINIB, RALOXIFENE HYDROCHLORIDE, ONARTUZUMAB, SAR-125844, ERTEBEREL, AMG-208, FULVESTRANT, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, ESTROGENS, CONJUGATED SYNTHETIC A, ESTROGENS, CONJUGATED, MK-8033, FISPEMIFENE, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, AFIMOXIFENE, MK-2461, MERESTINIB, DIETHYLSTILBESTROL DIPHOSPHATE, BMS-777607, BAZEDOXIFENE, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, MF101, AUS-131, CRIZOTINIB, TOREMIFENE, EMD-1204831, TIVANTINIB, ESTRAMUSTINE PHOSPHATE, NEDOSIRAN SODIUM, TELISOTUZUMAB, ESTETROL, TEPOTINIB, EMIBETUZUMAB, BPI-9016, ESTRAMUSTINE PHOSPHATE SODIUM, PF-04217903, ARZOXIFENE, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN |
| CMF-20304 | FREM1 | down-regulates | FEV | represses | R-3031 | 5 | 2 | Drugs (2) |
| CMF-20311 | FREM1 | down-regulates | FOXD2 | represses | R-2583 | 6 | 3 | Drugs (1) |
| CMF-20315 | FREM1 | down-regulates | MNX1 | represses | R-2260 | 4 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20316 | FREM1 | down-regulates | MNX1 | activates | R-2261 | 4 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20317 | FREM1 | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20318 | FREM1 | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) |
| CMF-20321 | FREM1 | down-regulates | VSX1 | represses | R-2356 | 16 | 4 | Drugs (33) Regulator Drugs (0)Regulon Drugs (33)SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB |
| CMF-20325 | FREM1 | up-regulates | CEBPB | activates | R-1304 | 23 | 3 | Drugs (6) |
| CMF-20331 | FREM1 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) |
| CMF-40014 | FREM1 | down-regulates | hsa-mir-153 | represses | R-152 | 62 | 23 | Drugs (1) |
| CMF-40015 | FREM1 | down-regulates | hsa-mir-153 | represses | R-177 | 62 | 23 | Drugs (7) |
| CMF-40016 | FREM1 | down-regulates | hsa-mir-153 | represses | R-227 | 62 | 23 | Drugs (9) |
| CMF-40017 | FREM1 | down-regulates | hsa-mir-153 | represses | R-2326 | 62 | 23 | Drugs (1) |
| CMF-40018 | FREM1 | down-regulates | hsa-mir-153 | represses | R-2402 | 62 | 23 | Drugs (1) |
| CMF-40019 | FREM1 | down-regulates | hsa-mir-153 | represses | R-2426 | 62 | 23 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-40020 | FREM1 | down-regulates | hsa-mir-153 | represses | R-2441 | 62 | 23 | Drugs (2) |
| CMF-40021 | FREM1 | down-regulates | hsa-mir-153 | represses | R-626 | 62 | 23 | Drugs (8) |
| CMF-40022 | FREM1 | down-regulates | hsa-mir-153 | represses | R-679 | 62 | 23 | Drugs (8) |
| CMF-40023 | FREM1 | down-regulates | hsa-mir-153 | represses | R-738 | 62 | 23 | Drugs (8) |
| CMF-40024 | FREM1 | down-regulates | hsa-mir-153 | represses | R-2798 | 62 | 23 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-40025 | FREM1 | down-regulates | hsa-mir-153 | represses | R-2837 | 62 | 23 | Drugs (1) |
| CMF-40026 | FREM1 | down-regulates | hsa-mir-153 | represses | R-3013 | 62 | 23 | Drugs (8) |
| CMF-40027 | FREM1 | down-regulates | hsa-mir-153 | represses | R-970 | 62 | 23 | Drugs (8) |
| CMF-40028 | FREM1 | down-regulates | hsa-mir-153 | represses | R-1006 | 62 | 23 | Drugs (8) |
| CMF-40029 | FREM1 | down-regulates | hsa-mir-153 | represses | R-1047 | 62 | 23 | Drugs (9) |
| CMF-40030 | FREM1 | down-regulates | hsa-mir-153 | represses | R-1067 | 62 | 23 | Drugs (7) |
| CMF-40031 | FREM1 | down-regulates | hsa-mir-153 | represses | R-3143 | 62 | 23 | Drugs (9) |
| CMF-40032 | FREM1 | down-regulates | hsa-mir-153 | represses | R-3231 | 62 | 23 | Drugs (7) |
| CMF-40033 | FREM1 | down-regulates | hsa-mir-153 | represses | R-3449 | 62 | 23 | Drugs (8) |
| CMF-40034 | FREM1 | down-regulates | hsa-mir-153 | represses | R-3459 | 62 | 23 | Drugs (8) |
| CMF-40035 | FREM1 | down-regulates | hsa-mir-153 | represses | R-3604 | 62 | 23 | Drugs (1) Regulator Drugs (0)Regulon Drugs (1)PROBUCOL |
| CMF-40036 | FREM1 | down-regulates | hsa-mir-153 | represses | R-1645 | 62 | 23 | Drugs (8) |
| CMF-40037 | FREM1 | down-regulates | hsa-mir-326 | represses | R-2260 | 16 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-40038 | FREM1 | down-regulates | hsa-mir-326 | represses | R-2532 | 16 | 5 | Drugs (8) |
| CMF-40039 | FREM1 | down-regulates | hsa-mir-326 | represses | R-2759 | 16 | 5 | Drugs (9) |
| CMF-40040 | FREM1 | down-regulates | hsa-mir-326 | represses | R-1906 | 16 | 5 | Drugs (9) |
| CMF-40041 | FREM1 | down-regulates | hsa-mir-326 | represses | R-2006 | 16 | 5 | Drugs (3) |
| CMF-40042 | FREM1 | down-regulates | hsa-mir-375 | represses | R-2260 | 61 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-40043 | FREM1 | down-regulates | hsa-mir-375 | represses | R-812 | 61 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-40044 | FREM1 | down-regulates | hsa-mir-375 | represses | R-2006 | 61 | 3 | Drugs (3) |