Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation EPHRIN_B_REVERSE_SIGNALING_PID_NCI_NATURE_nonsilent_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-33218 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | NFKB1 | activates | R-299 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-33228 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | IRF1 | activates | R-113 | 25 | 5 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)TAS0612, LANATOSIDE C, CEP-1347, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-33232 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | TEAD3 | activates | R-2107 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-33237 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | STAT5A | activates | R-2950 | 21 | 6 | Drugs (3) |
| CMF-33238 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | STAT5A | activates | R-2940 | 21 | 6 | Drugs (2) |
| CMF-33239 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | STAT5A | activates | R-2958 | 21 | 6 | Drugs (1) |
| CMF-33242 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | ELK3 | activates | R-3610 | 2 | 2 | Drugs (5) |
| CMF-33245 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | STAT5B | activates | R-1544 | 9 | 4 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)BINTRAFUSP ALFA, TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, LUSPATERCEPT, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, FRESOLIMUMAB, RONICICLIB, AT-7519, MARIMASTAT |
| CMF-33246 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | STAT5B | activates | R-1546 | 9 | 4 | Drugs (1) |
| CMF-33250 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | CEBPA | activates | R-2596 | 21 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-33251 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | CEBPA | activates | R-2604 | 21 | 4 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)ICATIBANT ACETATE, LABRADIMIL, FASITIBANT, BAMINERCEPT, ICATIBANT |
| CMF-33254 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | IRF8 | activates | R-403 | 18 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33255 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | IRF8 | activates | R-409 | 18 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |