Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation DENND1C_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-18935 | DENND1C | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18952 | DENND1C | down-regulates | VSX1 | activates | R-2361 | 16 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)CHENODIOL, URSODIOL, VANDETANIB, OBETICHOLIC ACID, TROPIFEXOR, PX-102, TERN-101, NIDUFEXOR, CILOFEXOR |
| CMF-39335 | DENND1C | up-regulates | hsa-mir-454-3p | represses | R-117 | 31 | 4 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-39336 | DENND1C | up-regulates | hsa-mir-454-3p | represses | R-2836 | 31 | 4 | Drugs (4) |
| CMF-39337 | DENND1C | up-regulates | hsa-mir-454-3p | represses | R-896 | 31 | 4 | Drugs (4) |
| CMF-39338 | DENND1C | up-regulates | hsa-mir-454-3p | represses | R-1613 | 31 | 4 | Drugs (4) |
| CMF-39339 | DENND1C | up-regulates | hsa-mir-98 | represses | R-2836 | 8 | 3 | Drugs (4) |
| CMF-39340 | DENND1C | up-regulates | hsa-mir-98 | represses | R-896 | 8 | 3 | Drugs (4) |
| CMF-39341 | DENND1C | up-regulates | hsa-mir-98 | represses | R-1613 | 8 | 3 | Drugs (4) |
| CMF-39342 | DENND1C | up-regulates | hsa-mir-20b | represses | R-117 | 44 | 2 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-39343 | DENND1C | up-regulates | hsa-mir-20b | represses | R-171 | 44 | 2 | Drugs (2) |