Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation CDKL5_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-17348 | CDKL5 | down-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-17351 | CDKL5 | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-17356 | CDKL5 | up-regulates | NKX2-2 | represses | R-3293 | 17 | 2 | Drugs (4) |
| CMF-17357 | CDKL5 | up-regulates | TCF7L1 | represses | R-450 | 9 | 1 | Drugs (24) Regulator Drugs (0)Regulon Drugs (24)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-38853 | CDKL5 | up-regulates | hsa-mir-551b | represses | R-3267 | 22 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMPLITAPIDE, PD-360324, MCS-110, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090 |
| CMF-38854 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-171 | 14 | 12 | Drugs (2) |
| CMF-38855 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-189 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38856 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-274 | 14 | 12 | Drugs (2) |
| CMF-38857 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-307 | 14 | 12 | Drugs (2) |
| CMF-38858 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 12 | Drugs (2) |
| CMF-38859 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-2489 | 14 | 12 | Drugs (2) |
| CMF-38860 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-2605 | 14 | 12 | Drugs (2) |
| CMF-38861 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-3028 | 14 | 12 | Drugs (2) |
| CMF-38862 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38863 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-1457 | 14 | 12 | Drugs (2) |
| CMF-38864 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-3695 | 14 | 12 | Drugs (2) |
| CMF-38865 | CDKL5 | up-regulates | hsa-mir-10b | represses | R-1847 | 14 | 12 | Drugs (2) |
| CMF-38866 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-171 | 79 | 12 | Drugs (2) |
| CMF-38867 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-189 | 79 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38868 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-274 | 79 | 12 | Drugs (2) |
| CMF-38869 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-307 | 79 | 12 | Drugs (2) |
| CMF-38870 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-411 | 79 | 12 | Drugs (2) |
| CMF-38871 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-2489 | 79 | 12 | Drugs (2) |
| CMF-38872 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-2605 | 79 | 12 | Drugs (2) |
| CMF-38873 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-3028 | 79 | 12 | Drugs (2) |
| CMF-38874 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-1091 | 79 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38875 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-1457 | 79 | 12 | Drugs (2) |
| CMF-38876 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-3695 | 79 | 12 | Drugs (2) |
| CMF-38877 | CDKL5 | up-regulates | hsa-mir-338 | represses | R-1847 | 79 | 12 | Drugs (2) |