Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation ATP8B4_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02186 | ATP8B4 | up-regulates | REST | represses | R-464 | 5 | 1 | Drugs (26) Regulator Drugs (0)Regulon Drugs (26)ACAMPROSATE CALCIUM, AV-101, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, MEMANTINE HYDROCHLORIDE, ORPHENADRINE HYDROCHLORIDE, NERAMEXANE, KETAMINE, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, ORPHENADRINE, FELBAMATE, AMANTADINE HYDROCHLORIDE, RAPASTINEL, LANICEMINE, ACAMPROSATE, RALFINAMIDE, GW468816, NERAMEXANE MESYLATE, ORPHENADRINE CITRATE, APIMOSTINEL, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, KETAMINE HYDROCHLORIDE |