Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HMBOX1 - homeobox containing 1
Function
Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 79618 | ENSG00000147421 | HMBOX1 | Q6NT76 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1045 | Pr-58 | 1 | 1 | 4 |
| R-1105 | Pr-58 | 1 | 1 | 8 |
| R-1147 | Pr-58 | 1 | 1 | 12 |
| R-1167 | Pr-58 | 1 | 1 | 6 |
| R-1227 | Pr-58 | 1 | 1 | 4 |
| R-1474 | Pr-58 | 1 | 1 | 7 |
| R-1528 | Pr-58 | 1 | 1 | 3 |
| R-1600 | Pr-58 | 1 | 1 | 7 |
| R-1632 | Pr-58 | 1 | 1 | 9 |
| R-1682 | Pr-58 | 1 | 1 | 17 |
| R-1792 | Pr-58 | 1 | 1 | 1 |
| R-2757 | Pr-58 | 1 | 1 | 19 |
| R-2891 | Pr-58 | 1 | 1 | 5 |
| R-3289 | Pr-58 | 1 | 1 | 5 |
| R-3462 | Pr-58 | 1 | 1 | 12 |
| R-3645 | Pr-58 | 1 | 1 | 6 |
| R-723 | Pr-58 | 1 | 1 | 14 |