Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

FOXO4 - forkhead box O4

Function

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4303 ENSG00000184481 FOXO4 P98177

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000184481 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00254CDC27up-regulatesFOXO4repressesR-3103171Drugs (8)
CMF-01354SDPRdown-regulatesFOXO4repressesR-3105172Drugs (86)
CMF-04492MYH8down-regulatesFOXO4repressesR-3111176Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04496MYH8down-regulatesFOXO4repressesR-3103176Drugs (8)
CMF-07181ATRXup-regulatesFOXO4repressesR-31071712Drugs (4)
CMF-07185ATRXup-regulatesFOXO4repressesR-31051712Drugs (86)
CMF-07186ATRXup-regulatesFOXO4repressesR-31111712Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07187ATRXup-regulatesFOXO4repressesR-31061712Drugs (20)
CMF-07191ATRXup-regulatesFOXO4repressesR-31031712Drugs (8)
CMF-08964ARHGAP32up-regulatesFOXO4repressesR-3107172Drugs (4)
CMF-08965ARHGAP32up-regulatesFOXO4repressesR-3106172Drugs (20)
CMF-09782MTF1up-regulatesFOXO4repressesR-3105172Drugs (86)
CMF-11293OR10H5up-regulatesFOXO4repressesR-3105172Drugs (86)
CMF-11452CYP4F22down-regulatesFOXO4repressesR-3111173Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-15754FN1down-regulatesFOXO4repressesR-3111174Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-15757FN1down-regulatesFOXO4repressesR-3103174Drugs (8)
CMF-17828HERC2down-regulatesFOXO4repressesR-3105171Drugs (86)
CMF-19045UPF1down-regulatesFOXO4repressesR-3103173Drugs (8)
CMF-19970ANO4down-regulatesFOXO4repressesR-3103173Drugs (8)
CMF-20626ADCY1down-regulatesFOXO4repressesR-3103173Drugs (8)
CMF-20746ALPK1down-regulatesFOXO4repressesR-3111173Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20747ALPK1down-regulatesFOXO4repressesR-3106173Drugs (20)
CMF-22024MOCS3up-regulatesFOXO4repressesR-3105171Drugs (86)
CMF-23001IDH1up-regulatesFOXO4repressesR-31071714Drugs (4)
CMF-23006IDH1up-regulatesFOXO4repressesR-31051714Drugs (86)
CMF-23007IDH1up-regulatesFOXO4repressesR-31111714Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-23009IDH1up-regulatesFOXO4repressesR-31061714Drugs (20)
CMF-23013IDH1up-regulatesFOXO4repressesR-31031714Drugs (8)
CMF-24119TP53up-regulatesFOXO4repressesR-3107179Drugs (4)
CMF-24122TP53up-regulatesFOXO4repressesR-3111179Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24123TP53up-regulatesFOXO4repressesR-3106179Drugs (20)
CMF-24127TP53up-regulatesFOXO4repressesR-3103179Drugs (8)
CMF-27227HTR3Adown-regulatesFOXO4repressesR-3106171Drugs (20)
CMF-29336C12orf51down-regulatesFOXO4repressesR-3107173Drugs (4)
CMF-29337C12orf51down-regulatesFOXO4repressesR-3106173Drugs (20)