Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
NKX3-1 - NK3 homeobox 1
Function
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 4824 | ENSG00000167034 | NKX3-1 | Q99801 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000167034 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01716 | SGOL2 | up-regulates | NKX3-1 | represses | R-788 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02444 | IGF2BP1 | up-regulates | NKX3-1 | represses | R-780 | 25 | 2 | Drugs (4) |
| CMF-05326 | PCSK6 | down-regulates | NKX3-1 | represses | R-770 | 25 | 4 | Drugs (3) |
| CMF-05327 | PCSK6 | down-regulates | NKX3-1 | represses | R-767 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-08486 | MSL3 | up-regulates | NKX3-1 | represses | R-770 | 25 | 4 | Drugs (3) |
| CMF-08487 | MSL3 | up-regulates | NKX3-1 | represses | R-767 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-09913 | CD163L1 | up-regulates | NKX3-1 | represses | R-788 | 25 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12848 | ABCB5 | up-regulates | NKX3-1 | represses | R-780 | 25 | 7 | Drugs (4) |
| CMF-13231 | SLC26A8 | down-regulates | NKX3-1 | represses | R-770 | 25 | 10 | Drugs (3) |
| CMF-13232 | SLC26A8 | down-regulates | NKX3-1 | represses | R-767 | 25 | 10 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-14163 | CD1D | down-regulates | NKX3-1 | represses | R-770 | 25 | 2 | Drugs (3) |