Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ZNF281 - zinc finger protein 281
Function
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 23528 | ENSG00000162702 | ZNF281 | Q9Y2X9 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000162702 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-07162 | ATRX | up-regulates | ZNF281 | activates | R-915 | 24 | 8 | Drugs (1) |
| CMF-07165 | ATRX | up-regulates | ZNF281 | activates | R-913 | 24 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11811 | DNAH17 | up-regulates | ZNF281 | activates | R-915 | 24 | 3 | Drugs (1) |
| CMF-13657 | FMN1 | up-regulates | ZNF281 | activates | R-915 | 24 | 14 | Drugs (1) |
| CMF-17075 | MAGEA6 | down-regulates | ZNF281 | activates | R-913 | 24 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18765 | LY75 | down-regulates | ZNF281 | activates | R-913 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22973 | IDH1 | up-regulates | ZNF281 | activates | R-915 | 24 | 15 | Drugs (1) |
| CMF-22976 | IDH1 | up-regulates | ZNF281 | activates | R-913 | 24 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24104 | TP53 | up-regulates | ZNF281 | activates | R-915 | 24 | 11 | Drugs (1) |
| CMF-24106 | TP53 | up-regulates | ZNF281 | activates | R-913 | 24 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25837 | CD163 | up-regulates | ZNF281 | activates | R-915 | 24 | 1 | Drugs (1) |
| CMF-26371 | ZFHX4 | down-regulates | ZNF281 | activates | R-913 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26516 | EGFR | down-regulates | ZNF281 | activates | R-915 | 24 | 8 | Drugs (1) |
| CMF-26519 | EGFR | down-regulates | ZNF281 | activates | R-913 | 24 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29255 | AQP10 | up-regulates | ZNF281 | activates | R-915 | 24 | 4 | Drugs (1) |