Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SRF - serum response factor

Function

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6722 ENSG00000112658 SRF P11831

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000112658 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-02090ABCA4up-regulatesSRFactivatesR-1140186Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-02094ABCA4up-regulatesSRFactivatesR-1138186Drugs (16)
CMF-02095ABCA4up-regulatesSRFactivatesR-1129186Drugs (20)
CMF-02815MST1up-regulatesSRFactivatesR-1129182Drugs (20)
CMF-05886FAM71Bdown-regulatesSRFactivatesR-1133181Drugs (4)
CMF-07954F5up-regulatesSRFactivatesR-1138183Drugs (16)
CMF-08325AFMup-regulatesSRFactivatesR-1140186Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-08327AFMup-regulatesSRFactivatesR-1133186Drugs (4)
CMF-08329AFMup-regulatesSRFactivatesR-1138186Drugs (16)
CMF-08330AFMup-regulatesSRFactivatesR-1129186Drugs (20)
CMF-08424COL17A1up-regulatesSRFactivatesR-1138182Drugs (16)
CMF-11251OR5W2up-regulatesSRFactivatesR-1140183Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-11253OR5W2up-regulatesSRFactivatesR-1138183Drugs (16)
CMF-11834SKIV2Lup-regulatesSRFactivatesR-1129182Drugs (20)
CMF-14051ANO9down-regulatesSRFactivatesR-1133185Drugs (4)
CMF-17519CNTNAP3down-regulatesSRFactivatesR-1129183Drugs (20)
CMF-18442LAMA1up-regulatesSRFactivatesR-1140184Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-18443LAMA1up-regulatesSRFactivatesR-1133184Drugs (4)
CMF-18445LAMA1up-regulatesSRFactivatesR-1129184Drugs (20)
CMF-20203GPR15up-regulatesSRFactivatesR-1133184Drugs (4)
CMF-23099UNC45Bup-regulatesSRFactivatesR-1129183Drugs (20)
CMF-23331CCDC132up-regulatesSRFactivatesR-1140184Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-23334CCDC132up-regulatesSRFactivatesR-1129184Drugs (20)
CMF-23353DOCK2up-regulatesSRFactivatesR-1129182Drugs (20)
CMF-24831SULT1B1up-regulatesSRFactivatesR-1133183Drugs (4)
CMF-24832SULT1B1up-regulatesSRFactivatesR-1138183Drugs (16)
CMF-24833SULT1B1up-regulatesSRFactivatesR-1129183Drugs (20)
CMF-27206HTR3Aup-regulatesSRFactivatesR-1129183Drugs (20)
CMF-27244PDYNup-regulatesSRFactivatesR-1133182Drugs (4)
CMF-27297CHD5up-regulatesSRFactivatesR-1140183Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-27299CHD5up-regulatesSRFactivatesR-1138183Drugs (16)
CMF-28186NEBLdown-regulatesSRFactivatesR-1129183Drugs (20)
CMF-28310EP400up-regulatesSRFactivatesR-1140181Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-29091TUBB4Qup-regulatesSRFactivatesR-1129184Drugs (20)
CMF-29174AQP10down-regulatesSRFactivatesR-1129183Drugs (20)
CMF-29852ABCC9up-regulatesSRFactivatesR-1140186Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-29855ABCC9up-regulatesSRFactivatesR-1133186Drugs (4)
CMF-29857ABCC9up-regulatesSRFactivatesR-1129186Drugs (20)
CMF-30511JHDM1Ddown-regulatesSRFactivatesR-1140185Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

ADAVOSERTIB

CMF-30515JHDM1Ddown-regulatesSRFactivatesR-1138185Drugs (16)