Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

LHX5 - LIM homeobox 5

Function

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
64211	ENSG00000089116	LHX5	Q9H2C1

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000089116 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01192	SKAP2	down-regulates	LHX5	represses	R-3061	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01193	SKAP2	down-regulates	LHX5	represses	R-3052	11	2	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-01559	CACNA1B	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-02413	LRP2	down-regulates	LHX5	represses	R-3056	11	3	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-02414	LRP2	down-regulates	LHX5	represses	R-3052	11	3	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-04776	ADAMTS20	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-04989	PRR23C	down-regulates	LHX5	represses	R-3061	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05397	KDELC2	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-05946	KIAA1244	down-regulates	LHX5	represses	R-3052	11	1	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-06117	HTR5A	down-regulates	LHX5	represses	R-3054	11	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-07442	THOC2	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-07482	LRRIQ1	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-08416	ADCY2	down-regulates	LHX5	represses	R-3061	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09444	ZIC4	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-11435	CYP4F22	down-regulates	LHX5	represses	R-3054	11	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-11894	PALM2-AKAP2	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-12387	MAST4	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-13735	TUBA3C	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-13736	TUBA3C	down-regulates	LHX5	represses	R-3052	11	2	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-14102	DENND2A	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-14530	GPR112	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-16823	ADAMTS2	down-regulates	LHX5	represses	R-3054	11	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-16889	CR2	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-17321	SYNJ2	down-regulates	LHX5	represses	R-3052	11	1	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-18490	LAMA1	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-19451	NF1	down-regulates	LHX5	represses	R-3054	11	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-19453	NF1	down-regulates	LHX5	represses	R-3052	11	6	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-20227	GPR15	down-regulates	LHX5	represses	R-3061	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24806	HIST1H2BE	down-regulates	LHX5	represses	R-3056	11	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-24807	HIST1H2BE	down-regulates	LHX5	represses	R-3061	11	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24974	NLRP1	down-regulates	LHX5	represses	R-3056	11	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-24976	NLRP1	down-regulates	LHX5	represses	R-3061	11	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26534	PLXNA4	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-27638	ANKRD36	down-regulates	LHX5	represses	R-3054	11	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-28952	NPHS1	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-28986	ZFC3H1	down-regulates	LHX5	represses	R-3061	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29073	DNAH3	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-29318	C12orf51	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-29800	SLC5A7	down-regulates	LHX5	represses	R-3054	11	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-29881	ABCC9	down-regulates	LHX5	represses	R-3056	11	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-30072	FAM126B	up-regulates	LHX5	represses	R-3061	11	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31054	PNPLA7	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-31477	SIGNALING_EVENTS_MEDIATED_BY_TCPTP	down-regulates	LHX5	represses	R-3061	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

LHX5 - LIM homeobox 5

Function

Causal Mechanistic Flows with ENSG00000089116 as Regulator

Regulator Drugs (0)

Regulon Drugs (0)

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Regulon Drugs (33)

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Regulon Drugs (8)

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Regulon Drugs (33)

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Regulon Drugs (8)

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Regulon Drugs (33)

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Regulon Drugs (8)

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Regulon Drugs (8)

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Regulon Drugs (2)

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Regulon Drugs (8)

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Regulon Drugs (8)

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Regulon Drugs (33)

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Regulon Drugs (33)

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Regulon Drugs (33)

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Regulon Drugs (8)

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