Program Pr-9

Genes (38)

SNAI2, NID2, ASPN, COL1A1, FN1, ISLR, LUM, COL6A2, RCN3, COL1A2, COL3A1, COL5A2, IL1R1, GLT8D2, COL5A1, OLFML2B, COL18A1, FBLN1, COL6A3, PCOLCE, BGN, CD248, P4HA2, PLS3, SERPINE1, MAN2A1, FHL2, ADAM12, RBMS1, ADAMTS1, ARSJ, PLXND1, LAMB1, SH2B3, THBD, TGFB1, LRRC32, TPM4

Regulons (30)

R-144, R-161, R-251, R-366, R-381, R-423, R-654, R-1128, R-1256, R-1287, R-1327, R-1413, R-1522, R-1837, R-1908, R-2001, R-2102, R-2115, R-2705, R-3045, R-3219, R-3365, R-3368, R-3375, R-3551, R-3562, R-3603, R-3617, R-3700, R-3706

Regulons in program Pr-9

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-144	1.64976	12	14
R-161	1.75921	13	8
R-251	1.63612	5	15
R-366	1.81546	7	7
R-381	1.66992	18	10
R-423	1.77017	16	4
R-654	1.76991	19	11
R-1128	1.81394	20	2
R-1256	2.10844	9	34
R-1287	1.46134	11	7
R-1327	1.65512	7	11
R-1413	1.69174	9	7
R-1522	1.89048	11	9
R-1837	1.59007	14	3
R-1908	1.79142	17	7
R-2001	1.58254	13	4
R-2102	1.69941	11	13
R-2115	2.02894	8	5
R-2705	2.49437	19	14
R-3045	0.800633	7	1
R-3219	2.17703	7	1
R-3365	1.62602	7	6
R-3368	1.74818	6	4
R-3375	1.77938	7	12
R-3551	1.4535	12	6
R-3562	1.57484	14	6
R-3603	1.99062	9	25
R-3617	1.73409	5	9
R-3700	1.22959	5	4
R-3706	1.152	7	3

Genes in program Pr-9

EnsEMBL Id	Entrez Id	Preferred
ENSG00000019549	6591	SNAI2
ENSG00000087303	22795	NID2
ENSG00000106819	54829	ASPN
ENSG00000108821	1277	COL1A1
ENSG00000115414	2335	FN1
ENSG00000129009	3671	ISLR
ENSG00000139329	4060	LUM
ENSG00000142173	1292	COL6A2
ENSG00000142552	57333	RCN3
ENSG00000164692	1278	COL1A2
ENSG00000168542	1281	COL3A1
ENSG00000204262	1290	COL5A2
ENSG00000115594	3554	IL1R1
ENSG00000120820	83468	GLT8D2
ENSG00000130635	1289	COL5A1
ENSG00000162745	25903	OLFML2B
ENSG00000182871	80781	COL18A1
ENSG00000077942	2192	FBLN1
ENSG00000163359	1293	COL6A3
ENSG00000106333	5118	PCOLCE
ENSG00000182492	633	BGN
ENSG00000174807	57124	CD248
ENSG00000072682	8974	P4HA2
ENSG00000102024	5358	PLS3
ENSG00000106366	5054	SERPINE1
ENSG00000112893	4124	MAN2A1
ENSG00000115641	2274	FHL2
ENSG00000148848	8038	ADAM12
ENSG00000153250	5937	RBMS1
ENSG00000154734	9510	ADAMTS1
ENSG00000180801	79642	ARSJ
ENSG00000004399	23129	PLXND1
ENSG00000091136	3912	LAMB1
ENSG00000111252	10019	SH2B3
ENSG00000178726	7056	THBD
ENSG00000105329	7040	TGFB1
ENSG00000137507	2615	LRRC32
ENSG00000167460	7171	TPM4

Causal Mechanistic Flows with Program Pr-9

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00347	COL6A3	up-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-00358	COL6A3	up-regulates	NFATC4	activates	R-2705	10	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-00419	MUC16	down-regulates	NFATC4	activates	R-2705	10	1	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-00775	TPTE2	down-regulates	NFATC4	activates	R-2705	10	3	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-01745	ACAN	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-01861	DAO	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-01963	PCDH9	down-regulates	GATA6	activates	R-1256	18	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-01969	PCDH9	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02188	ANO1	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02213	PPL	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02357	KCNH6	down-regulates	NFATC4	activates	R-2705	10	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02594	ROBO1	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02685	SLC9A10	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-02772	BRD8	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-03182	ZNF91	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-03403	CCDC60	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-03411	CCDC60	down-regulates	KLF4	activates	R-2115	10	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-04558	LAMC3	down-regulates	GATA6	activates	R-1256	18	8	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-05028	NUP210L	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-05098	SPEG	down-regulates	GATA6	activates	R-1256	18	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-05107	SPEG	down-regulates	HMGA2	activates	R-3603	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-05890	FAM71B	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-07149	ATRX	down-regulates	NFATC4	activates	R-2705	10	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-07717	TRPM2	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-08112	PLEKHG4B	down-regulates	GATA6	activates	R-1256	18	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-09058	DLG5	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-09158	RANBP6	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-09252	RP1	down-regulates	RXRA	activates	R-3219	13	3	Drugs (5) Regulator Drugs (2) SDX-101, DANTHRON Regulon Drugs (3) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ONTUXIZUMAB
CMF-09272	RP1	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-10232	SEMG1	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-10234	SEMG1	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-12648	REN	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-13820	ADAMTS8	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-14115	HEATR7B2	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-14120	HEATR7B2	down-regulates	NFATC4	activates	R-2705	10	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-14980	XK	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-15151	YEATS2	down-regulates	GATA6	activates	R-1256	18	5	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-15154	YEATS2	down-regulates	HMGA2	activates	R-3603	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-15932	OR13C8	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-16159	NLRP11	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-16233	USP11	down-regulates	GATA6	activates	R-1256	18	6	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-16260	USP11	down-regulates	NFATC4	activates	R-2705	10	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-17489	DYNC1I1	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-19448	NF1	up-regulates	HMGA2	activates	R-3603	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-19511	NF1	up-regulates	KLF4	activates	R-2115	10	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-19568	NF1	up-regulates	NFATC4	activates	R-2705	10	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-20054	ARHGEF16	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-20056	ARHGEF16	down-regulates	HMGA2	activates	R-3603	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-20281	ENAM	down-regulates	NFATC4	activates	R-2705	10	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-21146	ZNF208	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-22151	PDGFRA	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-22170	PDGFRA	down-regulates	KLF4	activates	R-2115	10	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-22182	PDGFRA	down-regulates	NFATC4	activates	R-2705	10	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-22723	IDH1	down-regulates	HMGA2	activates	R-3603	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-22940	IDH1	down-regulates	NFATC4	activates	R-2705	10	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-23395	FAM47C	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-23398	FAM47C	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-24613	THADA	down-regulates	KLF4	activates	R-2115	10	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-25055	IQSEC3	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-25341	PARG	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-26265	CEP250	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-26396	MAGEB1	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-26408	MAGEB1	down-regulates	NFATC4	activates	R-2705	10	3	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-27792	CSMD3	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28084	CELSR3	down-regulates	GATA6	activates	R-1256	18	4	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28291	KRTAP4-8	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28423	MYO9B	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28429	MYO9B	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28624	ARHGAP28	down-regulates	GATA6	activates	R-1256	18	3	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-28627	ARHGAP28	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-29351	RPL13AP6	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-29928	GABRA6	down-regulates	GATA6	activates	R-1256	18	1	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30540	JHDM1D	down-regulates	HMGA2	activates	R-3603	2	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30552	JHDM1D	down-regulates	NFATC4	activates	R-2705	10	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30684	ABCA13	down-regulates	GATA6	activates	R-1256	18	7	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30697	ABCA13	down-regulates	HMGA2	activates	R-3603	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30901	NPY5R	down-regulates	GATA6	activates	R-1256	18	2	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30905	NPY5R	down-regulates	NFATC4	activates	R-2705	10	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) L19IL2, AS-1409, ALEPLASININ, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-30911	LRRC55	down-regulates	KLF4	activates	R-2115	10	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-34505	SSPO	up-regulates	hsa-mir-98	represses	R-3603	8	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-35364	ATRX	up-regulates	hsa-mir-98	represses	R-3603	8	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-36301	MSL3	up-regulates	hsa-mir-98	represses	R-3603	8	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-37918	MYO1A	up-regulates	hsa-mir-98	represses	R-3603	8	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-38000	XK	up-regulates	hsa-mir-98	represses	R-3603	8	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-40686	IDH1	up-regulates	hsa-mir-98	represses	R-3603	8	8	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-41588	LTBP2	up-regulates	hsa-mir-98	represses	R-3603	8	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-41863	IQSEC3	up-regulates	hsa-mir-98	represses	R-3603	8	7	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN
CMF-43137	GABRA6	up-regulates	hsa-mir-98	represses	R-3603	8	1	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

Program

Pr-9

Program Pr-9

Genes (38)

Regulons (30)

Regulons in program Pr-9

Genes in program Pr-9

Causal Mechanistic Flows with Program Pr-9

Regulator Drugs (0)

Regulon Drugs (3)

Regulator Drugs (0)

Regulon Drugs (7)

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Regulon Drugs (7)

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Regulon Drugs (7)

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Regulon Drugs (5)

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Regulon Drugs (5)

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Regulon Drugs (3)

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Regulon Drugs (5)

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Regulon Drugs (3)

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Regulon Drugs (7)

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Regulon Drugs (5)

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Regulon Drugs (3)

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Regulon Drugs (3)

Regulator Drugs (0)

Regulon Drugs (5)

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Regulon Drugs (5)

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Regulon Drugs (2)

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Regulon Drugs (5)

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Regulon Drugs (5)

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Regulon Drugs (7)

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Regulon Drugs (5)

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Regulon Drugs (5)

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Regulon Drugs (5)

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Regulon Drugs (3)

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Regulon Drugs (5)

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Regulon Drugs (7)

Regulator Drugs (0)

Regulon Drugs (3)