Pr-83
Genes (383)
PSMB1, DNAJA2, OSTM1, LYRM1, POLR2C, BRF2, BUD31, ZNHIT1, TFAM, SLC25A11, B9D1, AIP, RAD1, STK16, CAPZA1, PYROXD1, MAD2L1BP, NDUFA1, SNRPB2, EMG1, DAD1, MED18, SDF2, BLOC1S1, EIF4E2, COX5B, NDUFB5, PTRH2, ITGB3BP, SNRPG, TPRKB, FAU, TIMM8B, ATP5J, MED7, MED8, SSR2, ATP5I, MRPL13, CRLF3, ALKBH1, SUB1, COQ6, TBCC, NOSIP, ZNF226, DERA, CENPQ, PSMA4, HEBP2, TAF11, CDC42, TSG101, ACTR6, EXOSC5, LYRM2, EIF3I, CHMP5, TGDS, TXNL1, TOMM22, PROCR, PSMA7, UBE2D3, COX6A1, MRPL18, GMNN, COX7A2, RNF7, EIF1B, SPCS1, HSPE1, SUMO1, ATP6V0B, ENY2, LYPLA1, SNRPD2, TIMM8A, OSGEPL1, ANAPC13, LSM4, NDUFA2, POMP, TIMM10, PIGC, MRPL44, GTF2B, TARBP2, GTF2A2, SEC11A, COPS3, ZNF593, PSMA5, TIPRL, RPS27A, RPS3A, GIN1, BTF3, COMMD3, RPS3, PIGF, TCEB1, AZIN1, TMBIM4, RER1, MRPL17, ATP5G1, MAGOH, TFB2M, SCNM1, GTPBP8, NUDT2, PRDX3, TMED3, ATP5L, SNUPN, CRADD, HINT1, SF3B5, C1GALT1C1, PPIH, PPP1CA, PARL, UBE2N, BOLA1, HIGD1A, RPS27L, ADH5, UBL5, SUPT4H1, MRPL33, PDCD6, PSMB3, TBCE, FRG1, CYB5R4, PSMC6, RPS19, RPL18A, ZNF410, SPCS3, EAPP, TPT1, RPS29, ZDHHC6, FAS, TRAPPC3, MRPS35, TMEM14A, PSMA6, CLN5, GPX7, ATP5F1, CTBS, DR1, ATP5E, UBE2D2, IL10, CCDC90B, COX17, NDUFA9, GOLGA7, MRPL39, DCK, POLR3K, MEMO1, UQCRQ, CAMLG, POLR2G, FNTA, RPS7, TCEAL1, LSM1, NDUFV2, CYC1, DIABLO, TOR3A, HSBP1, GTF2H5, RPL18, RPS5, MYNN, PPP2R3C, GMFB, ZNF35, NTHL1, MPG, MRPL24, GPS1, POLR1C, IMP3, HMBS, GSTP1, THG1L, TMEM123, RPN1, PPIA, ITGAE, MAGED2, POP4, C1QBP, C11orf58, PSMD9, CCNG1, PDCD10, PNO1, PCID2, GNG11, SLC35D2, COX7B, PPP4C, FAM96B, PAIP1, MRPS11, PSMD13, METTL9, LYRM4, MRPL46, ZNHIT3, SNX11, NDUFAB1, AGA, LRRC40, FH, BET1, C5orf15, AUP1, TXNDC9, LRRC42, NDUFB3, SEC22A, NQO2, YWHAQ, SRP9, CNIH4, EAF2, APIP, THYN1, CETN3, ADK, C14orf2, CBR3, SUCLG1, VKORC1, CNBP, PRKRA, NDUFA4, ATP5J2, ATP5O, HYPK, CIAPIN1, MRPL22, PPIE, HNRNPC, RBX1, C20orf24, ATG4A, NPM3, MRPS27, GNPDA1, BNIP1, NIT2, RPL24, BCAS2, WARS2, SDHB, PPP1R8, MED28, MRPS14, RAB9A, GLO1, MRPS7, UROD, PPT1, CCDC59, RNASEH2B, ATP6V1G1, BPHL, METTL5, WDR61, SDHC, ABHD10, CNOT8, VBP1, C2orf47, ANAPC10, CYB5A, TRAPPC2L, NFU1, CHCHD7, TRIAP1, SSR4, NPM1, 15-Sep, NDUFB1, DRG1, POLR3C, HSD17B11, MRPS12, RPS20, ERH, RPS13, RPS10, RNF113A, RPS15A, RPLP1, RPS11, RPL10, RPL35A, RPS23, RPL14, RPL10A, RPP21, TAF7, C8orf33, ZNF143, RPLP0, MTCH2, CASP6, LSM6, RFC2, RP2, C1orf109, CBX3, POT1, ABCB7, EIF2S1, ATG3, EIF3M, NRAS, ABHD5, CPNE3, PSMD10, COMMD10, TDRD7, SELT, EIF3E, EIF4A3, UFC1, RNF139, EBAG9, ATP5A1, RWDD2B, TMEM186, RPS25, CD9, LSM7, RPE, INTS12, NME7, DPY19L4, HMGN4, ZNF140, SLC25A5, PARD6A, HTRA2, PSMB4, NUP54, STX18, E2F6, TIMM17B, SPATA7, CCNB1IP1, TIA1, ALG5, ETNK1, SLC38A6, SLC35A1, ZNF552, CCT7, MTFR1, SNAPC1, INPP4A, VAPA, CALB1, MREG, SNX5, EIF3J, DECR1, ERGIC3, AMZ2, DDX47, PSMC4Regulons (33)
R-0, R-1, R-6, R-8, R-14, R-16, R-22, R-27, R-41, R-54, R-59, R-79, R-82, R-434, R-587, R-779, R-788, R-845, R-931, R-1439, R-1515, R-1583, R-1779, R-1870, R-2152, R-2178, R-2328, R-2638, R-2651, R-2661, R-3204, R-3470, R-3755Regulons in program Pr-83
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-0 | -0.427412 | 40 | 3 |
| R-1 | -1.2162 | 6 | 8 |
| R-6 | -0.627957 | 110 | 8 |
| R-8 | -1.71569 | 16 | 6 |
| R-14 | -0.650651 | 101 | 4 |
| R-16 | -1.78115 | 14 | 4 |
| R-22 | -0.650593 | 7 | 3 |
| R-27 | 0.577332 | 6 | 3 |
| R-41 | -0.713407 | 86 | 8 |
| R-54 | -0.909164 | 142 | 6 |
| R-59 | -2.46086 | 16 | 3 |
| R-79 | -0.32388 | 49 | 6 |
| R-82 | -1.33946 | 7 | 13 |
| R-434 | 0.220176 | 9 | 6 |
| R-587 | -0.380805 | 11 | 5 |
| R-779 | -0.476165 | 8 | 1 |
| R-788 | -2.11263 | 6 | 2 |
| R-845 | -0.798423 | 5 | 6 |
| R-931 | -1.45055 | 8 | 7 |
| R-1439 | -0.458525 | 11 | 5 |
| R-1515 | -0.567743 | 5 | 5 |
| R-1583 | -0.960811 | 7 | 14 |
| R-1779 | -1.07914 | 8 | 1 |
| R-1870 | -0.574119 | 10 | 5 |
| R-2152 | -1.11058 | 7 | 6 |
| R-2178 | -1.2168 | 16 | 8 |
| R-2328 | -0.152606 | 6 | 4 |
| R-2638 | -1.85834 | 7 | 6 |
| R-2651 | -0.63415 | 9 | 11 |
| R-2661 | -0.472993 | 7 | 6 |
| R-3204 | -1.25448 | 5 | 2 |
| R-3470 | -0.677979 | 9 | 17 |
| R-3755 | -0.986857 | 7 | 9 |
Genes in program Pr-83
Causal Mechanistic Flows with Program Pr-83
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01716 | SGOL2 | up-regulates | NKX3-1 | represses | R-788 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02637 | LBP | up-regulates | YY1 | activates | R-59 | 25 | 6 | Drugs (3) |
| CMF-03113 | DNAH8 | up-regulates | YY1 | activates | R-59 | 25 | 1 | Drugs (3) |
| CMF-09913 | CD163L1 | up-regulates | NKX3-1 | represses | R-788 | 25 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20515 | BCL11A | down-regulates | YY1 | activates | R-59 | 25 | 5 | Drugs (3) |
CMFlow summary not available
Enrichment summary not available