Pr-8
Genes (83)
LAMB1, TGFB1, SH2B3, CD93, OLFML2B, CD248, HYAL2, LXN, NOX4, MAP3K8, FRMD4B, PLVAP, HIGD1B, TMEM2, FOXF2, RASGRP3, SPON2, NOS3, JAG2, PAPSS2, TNFRSF14, PRKCH, FOXC1, COL5A3, PCDH12, LRRC32, CLEC1A, MMRN2, CDH5, OLFML2A, GJA4, MCAM, MMP9, COL4A2, SMTN, NDUFA4L2, COL4A1, PLXDC1, GPR4, PRR16, LBH, PTP4A3, LAMC3, TIE1, PDGFRB, KDR, ENPEP, ERG, CD34, SCARF1, NOTCH3, RRBP1, PXDN, DYSF, NFIC, BGN, SEMA3F, MXRA5, MYO1B, STARD8, TBC1D4, RGS3, CTSK, IER2, FZD4, GAS6, OLFML1, PLXND1, ENG, IGFBP4, COL18A1, BRD4, TRIOBP, VWF, CETP, RAP2B, PDGFB, RASIP1, PDLIM1, ZAP70, G0S2, PLAGL1, TBX2Regulons (35)
R-23, R-296, R-301, R-309, R-344, R-355, R-380, R-388, R-617, R-920, R-947, R-952, R-960, R-962, R-1009, R-1049, R-1202, R-1233, R-1334, R-1402, R-1519, R-1622, R-1822, R-2042, R-2092, R-2132, R-2369, R-2552, R-3262, R-3266, R-3272, R-3641, R-3712, R-3773, R-3796Regulons in program Pr-8
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-23 | 1.87266 | 6 | 1 |
| R-296 | 1.15312 | 15 | 12 |
| R-301 | 0.456578 | 10 | 10 |
| R-309 | 0.754963 | 6 | 7 |
| R-344 | 0.668898 | 7 | 8 |
| R-355 | 1.00035 | 5 | 9 |
| R-380 | 0.244222 | 18 | 10 |
| R-388 | 0.746042 | 10 | 4 |
| R-617 | 0.672694 | 8 | 1 |
| R-920 | 1.51236 | 9 | 4 |
| R-947 | 1.17005 | 19 | 5 |
| R-952 | 1.77591 | 11 | 1 |
| R-960 | 0.552252 | 8 | 6 |
| R-962 | 1.63073 | 8 | 3 |
| R-1009 | 1.49066 | 8 | 10 |
| R-1049 | 1.44317 | 7 | 3 |
| R-1202 | 0.272736 | 5 | 13 |
| R-1233 | 1.43968 | 8 | 13 |
| R-1334 | 0.26296 | 14 | 15 |
| R-1402 | 1.41297 | 10 | 9 |
| R-1519 | 0.799692 | 15 | 12 |
| R-1622 | 2.14562 | 5 | 4 |
| R-1822 | 1.19726 | 6 | 1 |
| R-2042 | 1.49431 | 9 | 5 |
| R-2092 | 1.63158 | 5 | 3 |
| R-2132 | 0.672832 | 6 | 5 |
| R-2369 | 0.668966 | 5 | 4 |
| R-2552 | 0.952142 | 6 | 9 |
| R-3262 | 1.12329 | 13 | 18 |
| R-3266 | 1.38784 | 7 | 8 |
| R-3272 | 0.570684 | 13 | 5 |
| R-3641 | 0.680249 | 6 | 2 |
| R-3712 | 0.60215 | 12 | 2 |
| R-3773 | 2.25552 | 5 | 8 |
| R-3796 | 1.07694 | 8 | 5 |
Genes in program Pr-8
Causal Mechanistic Flows with Program Pr-8
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-13303 | ADAM22 | up-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-16581 | RBM19 | down-regulates | TCF4 | activates | R-1622 | 17 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16805 | DDX11L2 | down-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-19655 | RPSAP58 | up-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-20455 | CUX2 | up-regulates | TCF4 | activates | R-1622 | 17 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20666 | CYP4B1 | up-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-24598 | THADA | down-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-25162 | FLT3 | up-regulates | TCF4 | activates | R-1622 | 17 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26317 | CHGB | up-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-29694 | ESRRB | down-regulates | TCF4 | activates | R-1622 | 17 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30535 | JHDM1D | down-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
| CMF-30749 | POLRMT | up-regulates | NR5A2 | activates | R-3773 | 3 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)BINTRAFUSP ALFA, LUSPATERCEPT, FRESOLIMUMAB, OCRIPLASMIN, LY-2382770 |
CMFlow summary not available
Enrichment summary not available