Pr-22
Genes (46)
GNAI2, ACTR3, FAM134B, HK2, RNASE3, LAP3, CD44, CHI3L2, RAB36, PYGL, PLEKHA4, AEBP1, GBP1, RASSF8, EGF, KCNMB1, HSPB8, AMFR, TIPARP, ERMAP, MICALL2, PFKFB3, FHL3, CCR10, SLC22A4, SH3BP2, TGFB2, CA3, RETSAT, SREBF1, ABCC3, FNDC4, CDKN1A, RHOB, KCNE4, TCN2, PRUNE2, PACRG, HSPB6, MTMR11, GYS1, SCARA3, RGS19, KCNJ8, ACOX2, DDORegulons (12)
R-352, R-1447, R-1680, R-1768, R-2478, R-2503, R-2945, R-3399, R-3404, R-3491, R-3509, R-3647Regulons in program Pr-22
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-352 | 2.36161 | 5 | 9 |
| R-1447 | 3.18866 | 20 | 3 |
| R-1680 | 2.54092 | 14 | 10 |
| R-1768 | 3.24169 | 6 | 28 |
| R-2478 | 3.3775 | 16 | 8 |
| R-2503 | 3.16051 | 8 | 29 |
| R-2945 | 3.57806 | 16 | 29 |
| R-3399 | 3.05101 | 7 | 5 |
| R-3404 | 3.05946 | 15 | 9 |
| R-3491 | 2.62911 | 11 | 8 |
| R-3509 | 2.14244 | 9 | 9 |
| R-3647 | 2.43949 | 8 | 37 |
Genes in program Pr-22
Causal Mechanistic Flows with Program Pr-22
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00512 | HMCN1 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
| CMF-00587 | HMCN1 | down-regulates | PGR | represses | R-3404 | 8 | 1 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-00642 | HMCN1 | up-regulates | STAT5A | activates | R-2945 | 21 | 11 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-00706 | HMCN1 | up-regulates | MAX | activates | R-3491 | 18 | 6 | Drugs (4) |
| CMF-00938 | TPTE | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
| CMF-01062 | ZNF292 | down-regulates | SREBF1 | activates | R-2503 | 12 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01246 | RNF168 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-01454 | MTOR | down-regulates | SATB1 | represses | R-1680 | 24 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-01957 | PCDH9 | down-regulates | STAT5A | activates | R-2945 | 21 | 13 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-01985 | PCDH9 | down-regulates | MAX | activates | R-3491 | 18 | 3 | Drugs (4) |
| CMF-02331 | ERG | down-regulates | PAX5 | represses | R-352 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03193 | GCC2 | down-regulates | STAT5A | activates | R-2945 | 21 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-03752 | DSP | up-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04179 | RBPJL | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-04204 | RBPJL | up-regulates | SREBF1 | activates | R-2503 | 12 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04259 | RBPJL | up-regulates | STAT5A | activates | R-2945 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-04513 | LAMC3 | up-regulates | SATB1 | represses | R-1680 | 24 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-04630 | CYP4F12 | down-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04652 | DMD | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-04656 | DMD | up-regulates | STAT5A | activates | R-2945 | 21 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-04662 | DMD | down-regulates | NR2C2 | represses | R-3509 | 3 | 1 | Drugs (2) |
| CMF-04732 | ADAMTS20 | up-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04760 | ADAMTS20 | up-regulates | STAT5A | activates | R-2945 | 21 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-04831 | NEFM | up-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04904 | ABCC5 | down-regulates | SREBF1 | activates | R-2503 | 12 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04917 | ABCC5 | down-regulates | IRF7 | activates | R-2478 | 21 | 9 | Drugs (2) |
| CMF-04950 | ABCC5 | down-regulates | STAT5A | activates | R-2945 | 21 | 10 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-05356 | KDELC2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-06123 | HTR5A | down-regulates | PAX5 | represses | R-352 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06263 | PCLO | up-regulates | SREBF1 | activates | R-2503 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06500 | RPL23AP32 | down-regulates | PGR | represses | R-3404 | 8 | 2 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-06644 | SCNN1G | down-regulates | STAT5A | activates | R-2945 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-06646 | SCNN1G | down-regulates | FOS | activates | R-3399 | 6 | 1 | Drugs (2) |
| CMF-06664 | ATRX | up-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
| CMF-06718 | ATRX | up-regulates | SATB1 | represses | R-1680 | 24 | 15 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-06774 | ATRX | down-regulates | SREBF1 | activates | R-2503 | 12 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06798 | ATRX | down-regulates | IRF7 | activates | R-2478 | 21 | 19 | Drugs (2) |
| CMF-06954 | ATRX | down-regulates | STAT5A | activates | R-2945 | 21 | 14 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-07387 | THOC2 | down-regulates | SATB1 | represses | R-1680 | 24 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-07412 | THOC2 | down-regulates | PGR | represses | R-3404 | 8 | 2 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-07455 | THOC2 | down-regulates | PAX5 | represses | R-352 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08004 | OR5D13 | down-regulates | NR2C2 | represses | R-3509 | 3 | 1 | Drugs (2) |
| CMF-08253 | KIF4A | down-regulates | SREBF1 | activates | R-2503 | 12 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08300 | KIF4A | down-regulates | MAX | activates | R-3491 | 18 | 2 | Drugs (4) |
| CMF-09016 | NALCN | up-regulates | PGR | represses | R-3404 | 8 | 1 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-09101 | TLL2 | down-regulates | PAX5 | represses | R-352 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09305 | HCLS1 | down-regulates | PAX5 | represses | R-352 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11187 | NRK | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
| CMF-11218 | NRK | down-regulates | PAX5 | represses | R-352 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11659 | AHR | down-regulates | PGR | represses | R-3404 | 8 | 3 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-11742 | BRDT | down-regulates | NR2C2 | represses | R-3509 | 3 | 1 | Drugs (2) |
| CMF-12119 | COL6A3 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-12868 | ATP11C | up-regulates | SREBF1 | activates | R-2503 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12920 | HTR3E | down-regulates | SREBF1 | activates | R-2503 | 12 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12941 | HTR3E | down-regulates | STAT5A | activates | R-2945 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-14162 | CD1D | up-regulates | MAX | activates | R-3491 | 18 | 2 | Drugs (4) |
| CMF-14384 | SLC4A1 | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
| CMF-14478 | PRKCD | down-regulates | SREBF1 | activates | R-2503 | 12 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14497 | PRKCD | down-regulates | FOS | activates | R-3399 | 6 | 1 | Drugs (2) |
| CMF-14503 | PRKCD | down-regulates | MAX | activates | R-3491 | 18 | 4 | Drugs (4) |
| CMF-14768 | SLC5A12 | down-regulates | NR2C2 | represses | R-3509 | 3 | 2 | Drugs (2) |
| CMF-14890 | SDHAP3 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-15048 | PTEN | up-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15594 | DCHS2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-15630 | DCHS2 | down-regulates | PGR | represses | R-3404 | 8 | 2 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-15791 | GRM3 | up-regulates | IRF7 | activates | R-2478 | 21 | 7 | Drugs (2) |
| CMF-15955 | KCNB2 | up-regulates | FOS | activates | R-3399 | 6 | 1 | Drugs (2) |
| CMF-16029 | NFIX | up-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16279 | COBLL1 | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
| CMF-16287 | COBLL1 | down-regulates | PGR | represses | R-3404 | 8 | 1 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-16358 | KCNG1 | down-regulates | SREBF1 | activates | R-2503 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16404 | SUSD5 | up-regulates | IRF7 | activates | R-2478 | 21 | 12 | Drugs (2) |
| CMF-16449 | SUSD5 | up-regulates | STAT5A | activates | R-2945 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-17134 | CDH18 | up-regulates | SREBF1 | activates | R-2503 | 12 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17163 | CDH18 | up-regulates | STAT5A | activates | R-2945 | 21 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-17173 | CDH18 | down-regulates | NR2C2 | represses | R-3509 | 3 | 1 | Drugs (2) |
| CMF-17313 | SYNJ2 | up-regulates | STAT5A | activates | R-2945 | 21 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-17446 | OR5L2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-18273 | MEGF8 | up-regulates | IRF9 | activates | R-1447 | 15 | 3 | Drugs (2) |
| CMF-18329 | DNMBP | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-18396 | FANCM | down-regulates | STAT5A | activates | R-2945 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-18426 | LAMA1 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
| CMF-18704 | MPP7 | down-regulates | IRF7 | activates | R-2478 | 21 | 6 | Drugs (2) |
| CMF-18796 | SLFN13 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-18804 | SLFN13 | up-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20085 | TDRD9 | up-regulates | IRF9 | activates | R-1447 | 15 | 8 | Drugs (2) |
| CMF-20432 | CUX2 | up-regulates | STAT5A | activates | R-2945 | 21 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-20532 | ADCY1 | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
| CMF-20543 | ADCY1 | down-regulates | SATB1 | represses | R-1680 | 24 | 8 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-20973 | KRTAP4-7 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
| CMF-21152 | SH3TC2 | up-regulates | MAX | activates | R-3491 | 18 | 2 | Drugs (4) |
| CMF-21428 | GRIK3 | down-regulates | PAX5 | represses | R-352 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21495 | POTEF | up-regulates | STAT5A | activates | R-2945 | 21 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-21555 | MUC17 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-21628 | MUC17 | up-regulates | IRF7 | activates | R-2478 | 21 | 12 | Drugs (2) |
| CMF-21806 | ITSN1 | down-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22105 | OR2T34 | down-regulates | STAT5A | activates | R-2945 | 21 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-22256 | IDH1 | up-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
| CMF-22328 | IDH1 | up-regulates | SATB1 | represses | R-1680 | 24 | 18 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-22398 | IDH1 | down-regulates | SREBF1 | activates | R-2503 | 12 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22438 | IDH1 | down-regulates | IRF7 | activates | R-2478 | 21 | 20 | Drugs (2) |
| CMF-22622 | IDH1 | down-regulates | STAT5A | activates | R-2945 | 21 | 16 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-22907 | IDH1 | up-regulates | NR2C2 | represses | R-3509 | 3 | 3 | Drugs (2) |
| CMF-23144 | LINGO2 | down-regulates | STAT5A | activates | R-2945 | 21 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-23176 | RNF17 | up-regulates | SREBF1 | activates | R-2503 | 12 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23336 | CCDC132 | down-regulates | PGR | represses | R-3404 | 8 | 1 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-23557 | TP53 | up-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
| CMF-23615 | TP53 | up-regulates | SATB1 | represses | R-1680 | 24 | 17 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-23675 | TP53 | down-regulates | SREBF1 | activates | R-2503 | 12 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23835 | TP53 | down-regulates | STAT5A | activates | R-2945 | 21 | 13 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-23926 | TP53 | down-regulates | FOS | activates | R-3399 | 6 | 5 | Drugs (2) |
| CMF-24046 | TP53 | up-regulates | NR2C2 | represses | R-3509 | 3 | 3 | Drugs (2) |
| CMF-24075 | TP53 | up-regulates | PAX5 | represses | R-352 | 6 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24311 | SMCHD1 | up-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24356 | SMCHD1 | up-regulates | MAX | activates | R-3491 | 18 | 1 | Drugs (4) |
| CMF-24687 | UGT2A3 | down-regulates | PAX5 | represses | R-352 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24760 | CHAT | down-regulates | PGR | represses | R-3404 | 8 | 1 | Drugs (22) Regulator Drugs (21)NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) |
| CMF-25010 | IQSEC3 | down-regulates | IRF9 | activates | R-1447 | 15 | 4 | Drugs (2) |
| CMF-25021 | IQSEC3 | down-regulates | SREBF1 | activates | R-2503 | 12 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25812 | CD163 | up-regulates | SATB1 | represses | R-1680 | 24 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-25978 | CTNNA2 | down-regulates | FGF9 | represses | R-1768 | 4 | 1 | Drugs (1) |
| CMF-26336 | CHGB | down-regulates | NR2C2 | represses | R-3509 | 3 | 1 | Drugs (2) |
| CMF-26448 | EGFR | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
| CMF-26986 | MGAM | up-regulates | SREBF1 | activates | R-2503 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27047 | DNAH5 | up-regulates | FOS | activates | R-3399 | 6 | 2 | Drugs (2) |
| CMF-27276 | CHD5 | down-regulates | FGF9 | represses | R-1768 | 4 | 4 | Drugs (1) |
| CMF-27332 | CHD5 | up-regulates | STAT5A | activates | R-2945 | 21 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-27569 | ANKRD36 | down-regulates | SATB1 | represses | R-1680 | 24 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-27671 | FAM83H | down-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27677 | FAM83H | down-regulates | IRF7 | activates | R-2478 | 21 | 6 | Drugs (2) |
| CMF-28918 | NR1H4 | down-regulates | NR2C2 | represses | R-3509 | 3 | 2 | Drugs (2) |
| CMF-29121 | FOLH1B | down-regulates | STAT5A | activates | R-2945 | 21 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-29146 | AQP10 | up-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
| CMF-29166 | AQP10 | up-regulates | SATB1 | represses | R-1680 | 24 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-29177 | AQP10 | down-regulates | SREBF1 | activates | R-2503 | 12 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29771 | SLC5A7 | up-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29826 | ABCC9 | down-regulates | FGF9 | represses | R-1768 | 4 | 3 | Drugs (1) |
| CMF-30032 | FAM126B | down-regulates | FGF9 | represses | R-1768 | 4 | 2 | Drugs (1) |
| CMF-33906 | RNF168 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-34534 | RBPJL | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 9 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-34892 | KDELC2 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-36506 | ZIC4 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-37236 | BRDT | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-37662 | TUBA3C | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-37857 | PRKCD | up-regulates | hsa-mir-328 | represses | R-2945 | 27 | 22 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-38031 | PTEN | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 10 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-38802 | CDH18 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-39102 | DNMBP | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-39893 | CRNN | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-42166 | NAALADL1 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-42343 | SDK1 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-42579 | FOXG1 | down-regulates | hsa-mir-328 | represses | R-2945 | 27 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-31249 | SHP2_SIGNALING | up-regulates | STAT5A | activates | R-2945 | 21 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-31468 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | STAT5A | activates | R-2945 | 21 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-31561 | EGF_RECEPTOR_SIGNALING_PATHWAY | up-regulates | STAT5A | activates | R-2945 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-31591 | EGF_RECEPTOR_SIGNALING_PATHWAY | up-regulates | MAX | activates | R-3491 | 18 | 5 | Drugs (4) |
| CMF-32108 | A6B1_AND_A6B4_INTEGRIN_SIGNALING | up-regulates | STAT5A | activates | R-2945 | 21 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-32818 | E_CADHERIN_SIGNALING_IN_KERATINOCYTES | up-regulates | STAT5A | activates | R-2945 | 21 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-33354 | ERBB1_DOWNSTREAM_SIGNALING | up-regulates | STAT5A | activates | R-2945 | 21 | 9 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |