Program

Program Pr-110

Genes (146)

NUDCD3, CYP46A1, CTNNA2, RASGRP2, BMP7, SYT17, DOCK4, SEC14L1, CC2D1A, PRKACB, MYO10, PITPNC1, ZDHHC14, APOLD1, FBXL7, NCDN, CLIP3, CRTC1, GIT1, SPTBN1, KIAA0513, ATP13A2, KIAA0232, CLSTN1, ARNT2, SPTAN1, NPTXR, PNMA2, ITPK1, GRIA3, LRP4, TEAD1, MAGI2, FRY, NCOA1, ABLIM1, ANKRD26, ALDH5A1, THRA, TERF2, PIK3R1, RAB6B, SLITRK5, ERBB4, NOS1AP, MYO16, MAPK10, TRIM23, RTN3, PPP3CA, NAP1L3, SLC9A6, CKB, SNPH, NDRG4, SLC6A1, SPTBN4, DYNC1H1, KBTBD11, MLF2, SLC4A3, ATP1B2, PINK1, ADORA1, PTDSS2, C3orf18, PCSK1N, SASH1, SERGEF, TCEA2, NGRN, EZH1, PIP5K1C, PIK3IP1, PBLD, CYP2J2, FAM107A, GPR37, MAOA, MAP3K5, MGLL, COBL, GRIK4, DEAF1, C11orf49, ZBTB20, ATP1A2, TUBG2, LMO3, CAMK2B, NEBL, ZFYVE21, SNTA1, BEX4, MEGF9, ALDOC, TRIM2, SLC1A2, ALDH2, CAP2, ALDH6A1, MBNL2, RTN1, VIP, SLC13A3, ACSL6, NTSR2, PDE4DIP, GPC5, SNN, SIRPA, FXYD1, C1orf21, ASTN1, DDAH1, TANC2, ATP2A2, PNMA1, PDE8B, TERF2IP, WASF3, DGKG, SOBP, PFKM, ZHX3, TAC1, WWC1, HSD11B1, MT1G, SYT11, LMO4, ANGPT1, PRKCA, GRIA1, ANK2, KLHL26, MAP3K13, FGF14, RUNDC3B, BTBD3, SUCLA2, GNG7, KCNIP1, CALM1, ARHGEF12, ABHD14A

Regulons (29)

R-34, R-555, R-569, R-708, R-732, R-755, R-760, R-949, R-1329, R-1348, R-1397, R-1456, R-1471, R-1687, R-1747, R-1854, R-2065, R-2141, R-2234, R-2282, R-2554, R-2597, R-2741, R-2829, R-3062, R-3065, R-3118, R-3484, R-3519

Regulons in program Pr-110

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-34	0.597944	15	3
R-555	0.867375	14	4
R-569	0.27273	5	4
R-708	-2.15045	13	8
R-732	-0.796627	7	12
R-755	-0.796627	7	11
R-760	0.123716	8	8
R-949	0.745963	16	9
R-1329	2.35049	6	2
R-1348	0.428951	6	13
R-1397	1.09628	11	20
R-1456	1.04577	7	1
R-1471	1.46335	7	2
R-1687	1.50752	7	6
R-1747	0.180669	6	11
R-1854	0.875139	27	10
R-2065	-0.133414	6	5
R-2141	0.182421	6	5
R-2234	1.23919	7	10
R-2282	0.474722	9	2
R-2554	0.884487	5	5
R-2597	2.652	9	5
R-2741	2.60804	6	3
R-2829	1.7061	16	9
R-3062	2.09705	5	4
R-3065	0.742721	8	4
R-3118	-0.613159	6	16
R-3484	0.586042	9	6
R-3519	1.27449	8	5

Genes in program Pr-110

EnsEMBL Id	Entrez Id	Preferred
ENSG00000015676	23386	NUDCD3
ENSG00000036530	10858	CYP46A1
ENSG00000066032	1496	CTNNA2
ENSG00000068831	10235	RASGRP2
ENSG00000101144	655	BMP7
ENSG00000103528	51760	SYT17
ENSG00000128512	9732	DOCK4
ENSG00000129657	6397	SEC14L1
ENSG00000132024	54862	CC2D1A
ENSG00000142875	5567	PRKACB
ENSG00000145555	4651	MYO10
ENSG00000154217	26207	PITPNC1
ENSG00000175048	79683	ZDHHC14
ENSG00000178878	81575	APOLD1
ENSG00000183580	23194	FBXL7
ENSG00000020129	23154	NCDN
ENSG00000105270	25999	CLIP3
ENSG00000105662	23373	CRTC1
ENSG00000108262	28964	GIT1
ENSG00000115306	6711	SPTBN1
ENSG00000135709	9764	KIAA0513
ENSG00000159363	23400	ATP13A2
ENSG00000170871	9778	KIAA0232
ENSG00000171603	22883	CLSTN1
ENSG00000172379	9915	ARNT2
ENSG00000197694	6709	SPTAN1
ENSG00000221890	23467	NPTXR
ENSG00000240694	10687	PNMA2
ENSG00000274958	3705	ITPK1
ENSG00000125675	2892	GRIA3
ENSG00000134569	4038	LRP4
ENSG00000187079	7003	TEAD1
ENSG00000187391	9863	MAGI2
ENSG00000073910	10129	FRY
ENSG00000084676	8648	NCOA1
ENSG00000099204	3983	ABLIM1
ENSG00000107890	22852	ANKRD26
ENSG00000112294	7915	ALDH5A1
ENSG00000126351	7067	THRA
ENSG00000132604	7014	TERF2
ENSG00000145675	5295	PIK3R1
ENSG00000154917	51560	RAB6B
ENSG00000165300	26050	SLITRK5
ENSG00000178568	2066	ERBB4
ENSG00000198929	9722	NOS1AP
ENSG00000282848	23026	MYO16
ENSG00000109339	5602	MAPK10
ENSG00000113595	373	TRIM23
ENSG00000133318	10313	RTN3
ENSG00000138814	5530	PPP3CA
ENSG00000186310	4675	NAP1L3
ENSG00000198689	10479	SLC9A6
ENSG00000166165	1152	CKB
ENSG00000101298	9751	SNPH
ENSG00000103034	65009	NDRG4
ENSG00000157103	6529	SLC6A1
ENSG00000160460	57731	SPTBN4
ENSG00000197102	1778	DYNC1H1
ENSG00000273645	9920	KBTBD11
ENSG00000089693	8079	MLF2
ENSG00000114923	6508	SLC4A3
ENSG00000129244	482	ATP1B2
ENSG00000158828	65018	PINK1
ENSG00000163485	134	ADORA1
ENSG00000282367	81490	PTDSS2
ENSG00000088543	51161	C3orf18
ENSG00000102109	27344	PCSK1N
ENSG00000111961	23328	SASH1
ENSG00000129158	26297	SERGEF
ENSG00000171703	6919	TCEA2
ENSG00000182768	51335	NGRN
ENSG00000108799	2145	EZH1
ENSG00000186111	23396	PIP5K1C
ENSG00000100100	113791	PIK3IP1
ENSG00000108187	64081	PBLD
ENSG00000134716	1573	CYP2J2
ENSG00000168309	11170	FAM107A
ENSG00000170775	2861	GPR37
ENSG00000189221	4128	MAOA
ENSG00000197442	4217	MAP3K5
ENSG00000074416	11343	MGLL
ENSG00000106078	23242	COBL
ENSG00000149403	2900	GRIK4
ENSG00000282712	10522	DEAF1
ENSG00000149179	79096	C11orf49
ENSG00000181722	26137	ZBTB20
ENSG00000018625	477	ATP1A2
ENSG00000037042	27175	TUBG2
ENSG00000048540	55885	LMO3
ENSG00000058404	816	CAMK2B
ENSG00000078114	10529	NEBL
ENSG00000100711	79038	ZFYVE21
ENSG00000101400	6640	SNTA1
ENSG00000102409	56271	BEX4
ENSG00000106780	1955	MEGF9
ENSG00000109107	230	ALDOC
ENSG00000109654	23321	TRIM2
ENSG00000110436	6506	SLC1A2
ENSG00000111275	217	ALDH2
ENSG00000112186	10486	CAP2
ENSG00000119711	4329	ALDH6A1
ENSG00000139793	10150	MBNL2
ENSG00000139970	6252	RTN1
ENSG00000146469	7432	VIP
ENSG00000158296	64849	SLC13A3
ENSG00000164398	23305	ACSL6
ENSG00000169006	23620	NTSR2
ENSG00000178104	9659	PDE4DIP
ENSG00000179399	2262	GPC5
ENSG00000184602	8303	SNN
ENSG00000198053	140885	SIRPA
ENSG00000266964	5348	FXYD1
ENSG00000116667	81563	C1orf21
ENSG00000152092	460	ASTN1
ENSG00000153904	23576	DDAH1
ENSG00000170921	26115	TANC2
ENSG00000174437	488	ATP2A2
ENSG00000176903	9240	PNMA1
ENSG00000113231	8622	PDE8B
ENSG00000166848	54386	TERF2IP
ENSG00000132970	10810	WASF3
ENSG00000058866	1608	DGKG
ENSG00000112320	55084	SOBP
ENSG00000152556	5213	PFKM
ENSG00000174306	23051	ZHX3
ENSG00000006128	6863	TAC1
ENSG00000113645	23286	WWC1
ENSG00000117594	3290	HSD11B1
ENSG00000125144	4495	MT1G
ENSG00000132718	23208	SYT11
ENSG00000143013	8543	LMO4
ENSG00000154188	284	ANGPT1
ENSG00000154229	5578	PRKCA
ENSG00000155511	2890	GRIA1
ENSG00000145362	287	ANK2
ENSG00000167487	55295	KLHL26
ENSG00000073803	9175	MAP3K13
ENSG00000102466	2259	FGF14
ENSG00000105784	154661	RUNDC3B
ENSG00000132640	22903	BTBD3
ENSG00000136143	8803	SUCLA2
ENSG00000176533	2788	GNG7
ENSG00000182132	30820	KCNIP1
ENSG00000198668	801	CALM1
ENSG00000196914	23365	ARHGEF12
ENSG00000248487	25864	ABHD14A

Causal Mechanistic Flows with Program Pr-110

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01680	SLCO5A1	down-regulates	FOXO1	activates	R-708	21	2	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-02461	DNAH9	up-regulates	FOXO1	activates	R-708	21	3	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-06468	LGSN	up-regulates	FOXO1	activates	R-708	21	2	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-14225	SEC23B	up-regulates	FOXO1	activates	R-708	21	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-24456	SEMA3C	down-regulates	FOXO1	activates	R-708	21	10	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-25499	OR8K3	up-regulates	FOXO1	activates	R-708	21	1	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-29591	ESRRB	down-regulates	FOXO1	activates	R-708	21	5	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB
CMF-29769	SLC5A7	up-regulates	FOXO1	activates	R-708	21	3	Drugs (45) Regulator Drugs (0) Regulon Drugs (45) PF-04691502, POZIOTINIB, DEXTROTHYROXINE, BGT-226, SONOLISIB, VOXTALISIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, APITOLISIB, DS-7423, NERATINIB, BMS-690514, AC-480, PAXALISIB, PICTILISIB, LIOTHYRONINE, DEXTROTHYROXINE SODIUM, DACOMITINIB, KBP5209, TARLOXOTINIB, VS-5584, VALPROIC ACID, SAMOTOLISIB, VANDETANIB, DACTOLISIB, DIVALPROEX SODIUM, GNF-Pf-5468, WX-037, CANERTINIB, PILARALISIB, TASELISIB, JNJ-26483327, LEVOTHYROXINE SODIUM, GEDATOLISIB, OMIPALISIB, AFATINIB DIMALEATE, AFATINIB, LIOTHYRONINE SODIUM, VALPROATE SODIUM, LEVOTHYROXINE, PA-799, GSK-1059615, BUPARLISIB, SF-1126, PANULISIB

CMFlow summary not available

Enrichment summary not available

Pr-110

Program Pr-110

Genes (146)

Regulons (29)

Regulons in program Pr-110

Genes in program Pr-110

Causal Mechanistic Flows with Program Pr-110

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)

Regulator Drugs (0)

Regulon Drugs (45)