Regulon – gbmMINER Portal

Regulon: R-914

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
13	-1.53552	1	0	Pr-60

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
22997	ENSG00000080854	IGSF9B	Q9UPX0
3301	ENSG00000086061	DNAJA1	P31689
57178	ENSG00000108175	ZMIZ1	Q9ULJ6
22954	ENSG00000119401	TRIM32	Q13049
9480	ENSG00000119547	ONECUT2	O95948
92	ENSG00000121989	ACVR2A	P27037
157922	ENSG00000130559	CAMSAP1	Q5T5Y3
26953	ENSG00000137040	RANBP6	O60518
81608	ENSG00000145216	FIP1L1	Q6UN15
55086	ENSG00000147231	CXorf57	Q6NSI4
26130	ENSG00000165219	GAPVD1	Q14C86
2562	ENSG00000166206	GABRB3	P28472
54880	ENSG00000183337	BCOR	Q6W2J9

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase
MIDAZOLAM HYDROCHLORIDE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ETAZOLATE	GABRB3	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA receptor beta-3 subunit positive allosteric modulator	2
CHLORDIAZEPOXIDE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ALPRAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ESTAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ACAMPROSATE CALCIUM	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4
MIDAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ETIFOXINE	GABRG2	Small molecule	ANTAGONIST	GABA-A receptor; anion channel antagonist	3
ZOPICLONE	GABRB3	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; agonist GABA site positive allosteric modulator	4
THIOPENTAL SODIUM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ESZOPICLONE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
PRAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
FLUMAZENIL	GABRG2	Small molecule	ALLOSTERIC ANTAGONIST	GABA-A receptor; anion channel allosteric antagonist	4
RESEQUINIL	GABRG2	Small molecule	INVERSE AGONIST	GABA-A receptor; anion channel inverse agonist	2
THIOPENTAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
CLONAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
PENTOBARBITAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
QUAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
METHARBITAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
PROPOFOL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
PADSEVONIL	SV2C	Small molecule	MODULATOR	Synaptic vesicle protein modulator	3
DESFLURANE	GABRG2	Small molecule	OPENER	Potassium channel subfamily K member 2 opener	4
BUTALBITAL	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
DARIGABAT	GABRG2	Small molecule	AGONIST	GABA-A receptor; anion channel agonist	2
TRIAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
GABOXADOL	GABRB3	Small molecule	AGONIST	GABA-A receptor; agonist GABA site agonist	3
CLORAZEPATE DIPOTASSIUM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ETOMIDATE	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4
REMIMAZOLAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
CENOBAMATE	SCN2A	Small molecule	INHIBITOR	Sodium channel alpha subunit inhibitor	4
CLOBAZAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
HSK-3486	GABRG2	Small molecule	AGONIST	GABA-A receptor; anion channel agonist	3
HALAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
MEPROBAMATE	GABRG2	Small molecule	AGONIST	GABA-A receptor; anion channel agonist	4
ISOFLURANE	KCNK10	Small molecule	OPENER	Potassium channel subfamily K member 2 opener	4
OXAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
FLURAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
CLORAZEPIC ACID	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
BREXANOLONE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
ACAMPROSATE	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4
PRIMIDONE	SCN2A	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
DIAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
TEMAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
REMIMAZOLAM BESYLATE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
SEVOFLURANE	KCNK2	Small molecule	OPENER	Potassium channel subfamily K member 18 opener	4
CLOMETHIAZOLE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
LORAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
GANAXOLONE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	3
ADIPIPLON	GABRG2	Small molecule	PARTIAL AGONIST	GABA-A receptor; anion channel partial agonist	2
TOPIRAMATE	CA4	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4
FLURAZEPAM HYDROCHLORIDE	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
CLOTIAZEPAM	GABRG2	Small molecule	POSITIVE ALLOSTERIC MODULATOR	GABA-A receptor; anion channel positive allosteric modulator	4
METHOXYFLURANE	GABRG2	Small molecule	AGONIST	Glycine receptor (alpha-1/beta) agonist	4

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-914

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs