Regulon

Regulon: R-791

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
28-1.0728710Pr-134Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
5725 ENSG00000011304 PTBP1 A6NLN1
55718 ENSG00000058600 POLR3E Q9NVU0
6047 ENSG00000063978 RNF4 P78317
55205 ENSG00000074657 ZNF532 Q9HCE3
9733 ENSG00000075856 SART3 Q15020
8555 ENSG00000081377 CDC14B O60729
79882 ENSG00000100722 ZC3H14 G3V411
22919 ENSG00000101367 MAPRE1 Q15691
22850 ENSG00000101544 ADNP2 Q6IQ32
23347 ENSG00000101596 SMCHD1 A6NHR9
10664 ENSG00000102974 CTCF P49711
6418 ENSG00000119335 SET Q01105
56252 ENSG00000119596 YLPM1 P49750
23435 ENSG00000120948 TARDBP G3V162
10657 ENSG00000121774 KHDRBS1 Q07666
5894 ENSG00000132155 RAF1 A0A8I5KR46
5495 ENSG00000138032 PPM1B O75688
9879 ENSG00000145833 DDX46 Q7L014
51631 ENSG00000146963 LUC7L2 Q9Y383
1105 ENSG00000153922 CHD1 O14646
23358 ENSG00000162402 USP24 Q9UPU5
26130 ENSG00000165219 GAPVD1 Q14C86
28511 ENSG00000168256 NKIRAS2 Q9NYR9
5747 ENSG00000169398 PTK2 E5RH01
171023 ENSG00000171456 ASXL1 Q8IXJ9
7690 ENSG00000172262 ZNF131 P52739
10949 ENSG00000177733 HNRNPA0 Q13151
54870 ENSG00000198218 QRICH1 A1L3Z9

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
XL-281RAF1Small moleculeINHIBITORSerine/threonine-protein kinase RAF inhibitor20
GSK-2256098PTK2Small moleculeINHIBITORFocal adhesion kinase 1 inhibitor20
SORAFENIB TOSYLATEPDGFRBSmall moleculeINHIBITORStem cell growth factor receptor inhibitor42
BI-853520PTK2Small moleculeINHIBITORFocal adhesion kinase 1 inhibitor10
MLN-2480RAF1Small moleculeINHIBITORRAF serine/threonine protein kinase inhibitor10
SORAFENIBFLT3Small moleculeINHIBITORStem cell growth factor receptor inhibitor42
VS-4718PTK2Small moleculeINHIBITORFocal adhesion kinase 1 inhibitor10
DEFACTINIBPTK2BSmall moleculeINHIBITORFocal adhesion kinase 1 inhibitor20
ARQ-736RAF1Small moleculeINHIBITORSerine/threonine-protein kinase RAF inhibitor10
LY-3009120ARAFSmall moleculeINHIBITORSerine/threonine-protein kinase A-Raf inhibitor10
LXH254RAF1Small moleculeINHIBITORB-raf/RAF proto-oncogene serine/threonine-protein kinase inhibitor20
CEP-37440ALKSmall moleculeINHIBITORFocal adhesion kinase 1 inhibitor10
REGORAFENIBKDRSmall moleculeINHIBITORTyrosine-protein kinase TIE-2 inhibitor42
CONTELTINIBPTK2Small moleculeINHIBITORProtein tyrosine kinase 2 beta inhibitor10
BELVARAFENIBRAF1Small moleculeINHIBITORRAF serine/threonine protein kinase inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-791

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs