Regulon

Regulon: R-491

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
51.2338810Pr-136Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
9921 ENSG00000022840 RNF10 Q8N5U6
6093 ENSG00000067900 ROCK1 Q13464
7374 ENSG00000076248 UNG E5KTA5
6878 ENSG00000106290 TAF6 A0A8I5KTW4
26156 ENSG00000171490 RSL1D1 O76021

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
BELUMOSUDIL MESYLATEROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor40
NETARSUDIL DIMESYLATEROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor40
BELUMOSUDILROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor40
NETARSUDILROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor40
FASUDILROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor30
AMA0076ROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor20
AT-13148MAPKAPK2Small moleculeINHIBITORRho-associated protein kinase inhibitor10
DE-104ROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor20
SAR-407899ROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor20
VEROSUDILROCK2Small moleculeINHIBITORRho-associated protein kinase inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-491

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs