Regulon – gbmMINER Portal

Regulon: R-380

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
18	0.244222	1	0	Pr-8

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5583	ENSG00000027075	PRKCH	P24723
10319	ENSG00000050555	LAMC3	Q9Y6N6
2296	ENSG00000054598	FOXC1	W6CJ52
7075	ENSG00000066056	TIE1	P35590
50509	ENSG00000080573	COL5A3	P25940
51294	ENSG00000113555	PCDH12	Q9NPG4
5159	ENSG00000113721	PDGFRB	P09619
3791	ENSG00000128052	KDR	P35968
2615	ENSG00000137507	LRRC32	Q14392
2028	ENSG00000138792	ENPEP	Q07075
51267	ENSG00000150048	CLEC1A	Q8NC01
2078	ENSG00000157554	ERG	P11308
57125	ENSG00000161381	PLXDC1	Q8IUK5
79812	ENSG00000173269	MMRN2	Q9H8L6
947	ENSG00000174059	CD34	P28906
2828	ENSG00000177464	GPR4	P46093
1003	ENSG00000179776	CDH5	P33151
8578	ENSG00000276336	SCARF1	Q14162

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
PAZOPANIB	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	1
MIDOSTAURIN	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	0
OSI-930	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	1	0
CRENOLANIB	PDGFRB	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	2
TIVOZANIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	2
PEGDINETANIB	KDR	Protein	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	2
BRIVANIB ALANINATE	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	0
RIVOCERANIB MESYLATE	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	3	2
SUNITINIB	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
AXITINIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	2
SORAFENIB TOSYLATE	PDGFRB	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
CEP-11981	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
BMS-690514	KDR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
TELATINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0
CYC-116	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	1	0
SORAFENIB	FLT3	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
CABOZANTINIB	MET	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	2
PAZOPANIB HYDROCHLORIDE	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	0
ALTIRATINIB	TEK	Small molecule	INHIBITOR	Neurotrophic tyrosine kinase receptor inhibitor	1	0
BRIVANIB	FGFR3	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	3	0
VATALANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	1
TANDUTINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	2	2
NINTEDANIB ESYLATE	FGFR3	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	4	0
RAF-265	KDR	Small molecule	INHIBITOR	Serine/threonine-protein kinase B-raf inhibitor	2	0
RIVOCERANIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	3	2
VANDETANIB	EPHA2	Small molecule	INHIBITOR	Tyrosine-protein kinase SRC inhibitor	4	2
FORETINIB	TEK	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
FRUQUINTINIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	0
IMATINIB MESYLATE	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
SUNITINIB MALATE	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
XL-999	PDGFRB	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	2	0
X-82	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
DOVITINIB	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	1
BECAPLERMIN	PDGFRB	Protein	AGONIST	Platelet-derived growth factor receptor agonist	4	0
SU-014813	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
SOTRASTAURIN	PRKD3	Small molecule	INHIBITOR	Protein kinase C (PKC) inhibitor	2	0
RAMUCIRUMAB	KDR	Antibody	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	2
ILORASERTIB	PDGFRB	Small molecule	INHIBITOR	Serine/threonine-protein kinase Aurora inhibitor	2	0
ENMD-2076	FLT3	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	2	0
ANLOTINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 3 inhibitor	3	2
LUCITANIB	KDR	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	2	0
UCN-01	CDK4	Small molecule	INHIBITOR	3-phosphoinositide dependent protein kinase-1 inhibitor	2	0
IMATINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
JI-101	PDGFRB	Small molecule	INHIBITOR	Ephrin type-B receptor 4 inhibitor	2	0
GLESATINIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
XL-820	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0
BMS-817378	MET	Small molecule	INHIBITOR	Hepatocyte growth factor receptor inhibitor	1	0
NINTEDANIB	FGFR3	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	4	2
CABOZANTINIB S-MALATE	MET	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	2
CHIAURANIB	AURKB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	0
MASITINIB	KIT	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	3	0
SEMAXANIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	0
LENVATINIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	0
TG100-801	EPHB4	Small molecule	INHIBITOR	SRC inhibitor	2	0
MOTESANIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor RET inhibitor	3	0
ORANTINIB	PDGFRB	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	3	0
FIRIBASTAT	ENPEP	Small molecule	INHIBITOR	Aminopeptidase A inhibitor	3	0
RG-1530	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	1	0
QUIZARTINIB	PDGFRB	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	0
RINUCUMAB	PDGFRB	Antibody	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	2	0
OLINVACIMAB	KDR	Antibody	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	2
SURUFATINIB	KDR	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	3	0
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	COL1A2	Enzyme	HYDROLYTIC ENZYME	Collagen hydrolytic enzyme	4	0
PF-00337210	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	1	0
OCRIPLASMIN	LAMA2	Enzyme	PROTEOLYTIC ENZYME	Fibronectin proteolytic enzyme	4	0
AEE-788	KDR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	1
TOSEDOSTAT	ANPEP	Small molecule	INHIBITOR	Aminopeptidase inhibitor	2	0
HENATINIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	1	0
TAK-593	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	1	0
LINIFANIB	CSF1R	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	0
4SC-203	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	1	0
TELBERMIN	KDR	Protein	AGONIST	Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) agonist	2	0
CM-082	FLT3	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	3	0
CEDIRANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	3
REGORAFENIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	4	2
FAMITINIB	KDR	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	0
GSK-690693	PRKACB	Small molecule	INHIBITOR	Protein kinase C (PKC) inhibitor	1	0
LENVATINIB MESYLATE	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	0
TIVOZANIB HYDROCHLORIDE	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	0
GOLVATINIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0
ENMD-981693	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0
OSI-632	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-380

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs