Regulon – gbmMINER Portal

Regulon: R-37

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
8	-1.20581	1	0	Pr-159

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
26277	ENSG00000092330	TINF2	H0YL20
6729	ENSG00000100883	SRP54	P61011
1432	ENSG00000112062	MAPK14	B4E0K5
55795	ENSG00000126226	PCID2	Q5JVF3
54407	ENSG00000134294	SLC38A2	Q96QD8
23589	ENSG00000153048	CARHSP1	Q9Y2V2
11124	ENSG00000185104	FAF1	Q9UNN5
151011	ENSG00000186522	10-Sep	Q9P0V9

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
FX-005	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
SEMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
TALMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
DILMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
TAK-715	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
NEFLAMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
ARRY-797	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	3	0
VX-702	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
RALIMETINIB	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	1
BMS-582949	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
ACUMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
PF-03715455	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
AZD-7624	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
GSK-610677	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	1	0
PEXMETINIB	MAPK14	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	1	0
LOSMAPIMOD	MAPK11	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	3	0
DORAMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
PH-797804	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
KC-706	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
PG-760564	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-37

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs