Regulon

Regulon: R-3667

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
6-1.6451310Pr-65Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
55692 ENSG00000007392 LUC7L Q1W6G4
23544 ENSG00000100095 SEZ6L Q9BYH1
11278 ENSG00000118922 KLF12 Q9Y4X4
2891 ENSG00000120251 GRIA2 P42262
57162 ENSG00000197329 PELI1 Q96FA3
6598 ENSG00000275837 SMARCB1 G5E975

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
MK-8777GRIA3Small moleculePOSITIVE ALLOSTERIC MODULATORGlutamate receptor ionotropic AMPA positive allosteric modulator20
PERAMPANELGRIA3Small moleculeANTAGONISTGlutamate receptor ionotropic AMPA antagonist40
PF-04958242GRIA3Small moleculePOSITIVE ALLOSTERIC MODULATORGlutamate receptor ionotropic AMPA positive allosteric modulator20
TEZAMPANELGRIK4Small moleculeANTAGONISTGlutamate receptor ionotropic kainate antagonist20
SELURAMPANELGRIK4Small moleculeANTAGONISTGlutamate receptor ionotropic kainate antagonist20
TALAMPANELGRIA2Small moleculeANTAGONISTGlutamate receptor ionotropic, AMPA 2 antagonist22
FARAMPATORGRIA3Small moleculePOSITIVE ALLOSTERIC MODULATORGlutamate receptor ionotropic AMPA positive allosteric modulator20
ZONAMPANELGRIA3Small moleculeANTAGONISTGlutamate receptor ionotropic AMPA antagonist20
TAK-653GRIA3Small moleculePOSITIVE ALLOSTERIC MODULATORGlutamate receptor ionotropic AMPA positive allosteric modulator20
TOPIRAMATECA4Small moleculePOSITIVE MODULATORGABA-A receptor; anion channel positive modulator40
MIBAMPATORGRIA3Small moleculePOSITIVE ALLOSTERIC MODULATORGlutamate receptor ionotropic AMPA positive allosteric modulator20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3667

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs