Regulon

Regulon: R-3528

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
5-2.7879910Pr-120Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
10203 ENSG00000064989 CALCRL Q16602
8869 ENSG00000115525 ST3GAL5 Q9UNP4
650 ENSG00000125845 BMP2 P12643
80774 ENSG00000136490 LIMD2 Q9BT23
23625 ENSG00000176973 FAM89B Q8N5H3

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
RIMEGEPANT SULFATECALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist40
TELCAGEPANTCALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist30
ATOGEPANTCALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist40
UBROGEPANTCALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist40
ERENUMABCALCRLAntibodyANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist40
RIMEGEPANTCALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist40
BI-44370CALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist20
MK3207CALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist20
DAVALINTIDERAMP1ProteinAGONISTCalcitonin gene-related peptide type 1 receptor agonist20
OLCEGEPANTCALCRLSmall moleculeANTAGONISTCalcitonin gene-related peptide type 1 receptor antagonist20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3528

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs