Regulon: R-325
Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.
Regulon Summary
Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.
| Genes | Cox Hazard Ratio | Regulators | Causal Flows | Transcriptional Programs | Hallmarks |
|---|---|---|---|---|---|
| 7 | 0.383595 | 1 | 0 | Pr-103 |           |
Regulon Genes
List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.
| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 80833 | ENSG00000128284 | APOL3 | O95236 |
| 3663 | ENSG00000128604 | IRF5 | Q13568 |
| 3695 | ENSG00000139626 | ITGB7 | P26010 |
| 11322 | ENSG00000141524 | TMC6 | Q7Z403 |
| 6886 | ENSG00000162367 | TAL1 | P17542 |
| 154 | ENSG00000169252 | ADRB2 | P07550 |
| 1240 | ENSG00000174600 | CMKLR1 | Q99788 |
Regulon Drugs
| Name | Approved Symbol | Type | Action Type | Mechanism of Action | Max Trial Phase | Max GBM Phase |
|---|---|---|---|---|---|---|
| FORMOTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| PINDOLOL | ADRB2 | Small molecule | PARTIAL AGONIST | Beta-2 adrenergic receptor partial agonist | 4 | 0 |
| ALBUTEROL SULFATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| ESMOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| PENBUTOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-2 adrenergic receptor antagonist | 4 | 0 |
| ABRILUMAB | ITGA4 | Antibody | INHIBITOR | Integrin alpha-4/beta-7 inhibitor | 2 | 0 |
| CARVEDILOL | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor beta antagonist | 4 | 0 |
| EPINEPHRINE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| PROPRANOLOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| CARTEOLOL | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor beta antagonist | 4 | 0 |
| TIMOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| PIRBUTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| PROCATEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 3 | 0 |
| INDACATEROL MALEATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| ESMOLOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| BUCINDOLOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 2 | 0 |
| ISOXSUPRINE HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor alpha-1 antagonist | 4 | 0 |
| GSK159802 | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 1 | 0 |
| LEVOBUNOLOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| NOREPINEPHRINE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| DROXIDOPA | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| LABETALOL | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor antagonist | 4 | 0 |
| AZD3199 | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| PF-00610355 | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| PROPAFENONE HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| ETROLIZUMAB | ITGB7 | Antibody | ANTAGONIST | Integrin beta-7 antagonist | 3 | 0 |
| OLODATEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| NADOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| ARFORMOTEROL TARTRATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| RIMITEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| NEBIVOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| PIRBUTEROL ACETATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| EPINEPHRINE BITARTRATE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| CARMOTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| CARTEOLOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor beta antagonist | 4 | 0 |
| METAPROTERENOL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| NOREPINEPHRINE BITARTRATE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| BAMBUTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 3 | 0 |
| NATALIZUMAB | ITGA4 | Antibody | INHIBITOR | Integrin alpha-4/beta-1 inhibitor | 4 | 0 |
| NEBIVOLOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| INDACATEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| OLODATEROL HYDROCHLORIDE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| EPHEDRINE HYDROCHLORIDE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| FIRATEGRAST | ITGB1 | Small molecule | ANTAGONIST | Integrin alpha-4/beta-1 antagonist | 2 | 0 |
| DOBUTAMINE HYDROCHLORIDE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| METAPROTERENOL SULFATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| LABETALOL HYDROCHLORIDE | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor antagonist | 4 | 0 |
| VEDOLIZUMAB | ITGA4 | Antibody | INHIBITOR | Integrin alpha-4/beta-7 inhibitor | 4 | 0 |
| LEVALBUTEROL TARTRATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| VILANTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| CARVEDILOL PHOSPHATE | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor beta antagonist | 4 | 0 |
| EPHEDRINE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| LEVALBUTEROL HYDROCHLORIDE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| ISOPROTERENOL HYDROCHLORIDE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor beta agonist | 4 | 0 |
| TIMOLOL MALEATE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| SALMETEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| ISOXSUPRINE | ADRB2 | Small molecule | ANTAGONIST | Adrenergic receptor alpha-1 antagonist | 4 | 0 |
| LEVOSALBUTAMOL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| TERBUTALINE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| LY377604 | ADRB2 | Small molecule | AGONIST | Beta-3 adrenergic receptor agonist | 2 | 0 |
| FORMOTEROL FUMARATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| BUCINDOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 2 | 0 |
| OXPRENOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| VILANTEROL TRIFENATATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| DIPIVEFRIN | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| ISOETHARINE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| LAS190792 | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 1 | 0 |
| ALBUTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| METIPRANOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-2 adrenergic receptor antagonist | 4 | 0 |
| ARFORMOTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| BEDORADRINE SULFATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| LEVOBUNOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| TERBUTALINE SULFATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| NAVAFENTEROL | ADRB2 | Small molecule | ANTAGONIST | Muscarinic acetylcholine receptor M3 antagonist | 2 | 0 |
| CELIPROLOL | ADRB2 | Small molecule | PARTIAL AGONIST | Beta-2 adrenergic receptor partial agonist | 4 | 0 |
| PROPRANOLOL | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| BITOLTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| MEPHENTERMINE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| SOTALOL HYDROCHLORIDE | KCNH2 | Small molecule | ANTAGONIST | Beta-2 adrenergic receptor antagonist | 4 | 0 |
| BEDORADRINE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| BATEFENTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| CLENBUTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| DOBUTAMINE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| TULOBUTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| EPHEDRINE SULFATE | ADRB2 | Small molecule | AGONIST | Adrenergic receptor agonist | 4 | 0 |
| MILVETEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
| ISOPROTERENOL | ADRB2 | Small molecule | AGONIST | Adrenergic receptor beta agonist | 4 | 0 |
| SOTALOL | KCNH2 | Small molecule | ANTAGONIST | Beta-2 adrenergic receptor antagonist | 4 | 0 |
| FENOTEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| PROPAFENONE | ADRB2 | Small molecule | ANTAGONIST | Beta-1 adrenergic receptor antagonist | 4 | 0 |
| SALMETEROL XINAFOATE | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 4 | 0 |
| ABEDITEROL | ADRB2 | Small molecule | AGONIST | Beta-2 adrenergic receptor agonist | 2 | 0 |
Causal Flows
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulon R-325
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|