Regulon: R-3199
Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.
Regulon Summary
Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.
| Genes | Cox Hazard Ratio | Regulators | Causal Flows | Transcriptional Programs | Hallmarks |
|---|---|---|---|---|---|
| 8 | 0.2319 | 1 | 0 | Pr-98 |           |
Regulon Genes
List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.
| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 57535 | ENSG00000116299 | KIAA1324 | Q6UXG2 |
| 7277 | ENSG00000127824 | TUBA4A | P68366 |
| 5409 | ENSG00000141744 | PNMT | P11086 |
| 79590 | ENSG00000143314 | MRPL24 | Q96A35 |
| 4726 | ENSG00000145494 | NDUFS6 | O75380 |
| 5261 | ENSG00000156873 | PHKG2 | P15735 |
| 10248 | ENSG00000172336 | POP7 | O75817 |
| 79135 | ENSG00000184831 | APOO | Q9BUR5 |
Regulon Drugs
| Name | Approved Symbol | Type | Action Type | Mechanism of Action | Max Trial Phase | Max GBM Phase |
|---|---|---|---|---|---|---|
| ERIBULIN MESYLATE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| SAGOPILONE | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 2 | 2 |
| AGS-16C3F | TUBB1 | Unknown | DISRUPTING AGENT | Tubulin disrupting agent | 2 | 0 |
| TELISOTUZUMAB VEDOTIN | MET | Antibody | BINDING AGENT | Hepatocyte growth factor receptor binding agent | 3 | 0 |
| DOCETAXEL | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| FOSBRETABULIN DISODIUM | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 2 | 0 |
| VINCRISTINE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 3 |
| VINFLUNINE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| LEXIBULIN | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 2 | 1 |
| VINCRISTINE SULFATE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 3 |
| TRASTUZUMAB EMTANSINE | ERBB2 | Antibody | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| ENFORTUMAB VEDOTIN | TUBB1 | Antibody | BINDING AGENT | Nectin-4 binding agent | 4 | 0 |
| VINORELBINE TARTRATE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| LIFASTUZUMAB VEDOTIN | TUBB1 | Antibody | BINDING AGENT | Sodium-dependent phosphate transport protein 2B binding agent | 2 | 0 |
| KOS-1584 | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 2 | 0 |
| PRALUZATAMAB RAVTANSINE | ALCAM | Antibody | INHIBITOR | Tubulin inhibitor | 2 | 0 |
| LADIRATUZUMAB VEDOTIN | TUBB1 | Antibody | INHIBITOR | Tubulin inhibitor | 2 | 0 |
| PACLITAXEL | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 1 |
| CROLIBULIN | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| PACLITAXEL POLIGLUMEX | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 3 | 0 |
| PATUPILONE | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 3 | 1 |
| ASG-5ME | TUBB1 | Antibody | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| ANG1005 | LRP1 | Protein | BINDING AGENT | Prolow-density lipoprotein receptor-related protein 1 binding agent | 3 | 2 |
| PINATUZUMAB VEDOTIN | TUBB1 | Antibody | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| VERUBULIN | TUBB1 | Small molecule | DISRUPTING AGENT | Tubulin disrupting agent | 2 | 2 |
| VINBLASTINE SULFATE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| VINORELBINE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 2 |
| METFORMIN | GPD2 | Small molecule | INHIBITOR | Mitochondrial complex I (NADH dehydrogenase) inhibitor | 4 | 2 |
| METFORMIN HYDROCHLORIDE | GPD2 | Small molecule | INHIBITOR | Mitochondrial complex I (NADH dehydrogenase) inhibitor | 4 | 0 |
| DAVUNETIDE | TUBB1 | Protein | STABILISER | Tubulin stabiliser | 2 | 0 |
| BELANTAMAB MAFODOTIN | TUBB1 | Antibody | BINDING AGENT | Tumor necrosis factor receptor superfamily member 17 binding agent | 4 | 0 |
| FOSBRETABULIN | TUBB1 | Small molecule | DISRUPTING AGENT | Tubulin disrupting agent | 3 | 0 |
| MIRVETUXIMAB SORAVTANSINE | FOLR1 | Antibody | INHIBITOR | Tubulin inhibitor | 3 | 0 |
| IXABEPILONE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 1 |
| POLATUZUMAB VEDOTIN | TUBB1 | Antibody | BINDING AGENT | B-cell antigen receptor complex-associated protein beta chain binding agent | 4 | 0 |
| T-900607 | TUBB1 | Small molecule | DISRUPTING AGENT | Tubulin disrupting agent | 2 | 0 |
| APRUTUMAB IXADOTIN | TUBB1 | Antibody | BINDING AGENT | Fibroblast growth factor receptor 2 binding agent | 1 | 0 |
| PLINABULIN | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 3 | 0 |
| TISOTUMAB VEDOTIN | F3 | Antibody | BINDING AGENT | Coagulation factor III binding agent | 4 | 0 |
| DOLASTATIN-10 | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 2 | 0 |
| ME-344 | NDUFA4 | Small molecule | INHIBITOR | Mitochondrial complex I (NADH dehydrogenase) inhibitor | 1 | 0 |
| FOSBRETABULIN TROMETHAMINE | TUBB1 | Small molecule | DISRUPTING AGENT | Tubulin disrupting agent | 2 | 0 |
| SAR-408701 | TUBB1 | Unknown | BINDING AGENT | Carcinoembryonic antigen-related cell adhesion molecule 5 binding agent | 3 | 0 |
| CABAZITAXEL | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 2 |
| PACLITAXEL DOCOSAHEXAENOIC ACID | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 3 | 0 |
| ERIBULIN | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| BMS-275183 | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 2 | 0 |
| INDUSATUMAB VEDOTIN | TUBB1 | Antibody | BINDING AGENT | Heat-stable enterotoxin receptor binding agent | 2 | 0 |
| GLEMBATUMUMAB VEDOTIN | TUBB1 | Antibody | BINDING AGENT | Transmembrane glycoprotein NMB binding agent | 2 | 0 |
| COLCHICINE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| VANDORTUZUMAB VEDOTIN | STEAP1 | Antibody | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| VINBLASTINE | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| BRENTUXIMAB VEDOTIN | TNFRSF8 | Antibody | INHIBITOR | Tubulin inhibitor | 4 | 0 |
| EPOTHILONE D | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 2 | 0 |
| SOFITUZUMAB VEDOTIN | TUBB1 | Antibody | BINDING AGENT | Mucin-16 binding agent | 1 | 0 |
| INDIBULIN | TUBB1 | Small molecule | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| AZINTUXIZUMAB VEDOTIN | TUBB1 | Antibody | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| LAROTAXEL | TUBB1 | Small molecule | STABILISER | Tubulin stabiliser | 3 | 0 |
| RG-7841 | TUBB1 | Unknown | INHIBITOR | Tubulin inhibitor | 1 | 0 |
| LORVOTUZUMAB MERTANSINE | NCAM1 | Antibody | INHIBITOR | Tubulin inhibitor | 2 | 0 |
Causal Flows
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulon R-3199
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|