Regulon – gbmMINER Portal

Regulon: R-3130

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
9	1.49098	1	0	Pr-124

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
8530	ENSG00000077984	CST7	O76096
2191	ENSG00000078098	FAP	Q12884
958	ENSG00000101017	CD40	P25942
51311	ENSG00000101916	TLR8	Q9NR97
914	ENSG00000116824	CD2	P06729
26191	ENSG00000134242	PTPN22	E9PMT0
9050	ENSG00000152229	PSTPIP2	Q9H939
3600	ENSG00000164136	IL15	P40933
1675	ENSG00000274619	CFD	P00746

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase
SELICRELUMAB	CD40	Antibody	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	1
LUCATUMUMAB	CD40	Antibody	ANTAGONIST	Tumor necrosis factor receptor superfamily member 5 antagonist	2
CDX-1140	CD40	Unknown	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	2
F19 131I	FAP	Antibody	BINDING AGENT	Fibroblast activation protein alpha binding agent	3
DACETUZUMAB	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
PG-102	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
BLESELUMAB	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
ALEFACEPT	CD2	Protein	INHIBITOR	T-cell surface antigen CD2 inhibitor	4
SIMLUKAFUSP ALFA	FAP	Protein	BINDING AGENT	Fibroblast activation protein alpha binding agent	2
SELGANTOLIMOD	TLR8	Small molecule	AGONIST	Toll-like receptor 8 agonist	2
MOTOLIMOD	TLR8	Small molecule	AGONIST	Toll-like receptor 8 agonist	2
CD40 LIGAND	CD40	Unknown	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	2
SOTIGALIMAB	CD40	Antibody	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	2
TELRATOLIMOD	TLR8	Small molecule	AGONIST	Toll-like receptor 8 agonist	1
SIBROTUZUMAB	FAP	Antibody	BINDING AGENT	Fibroblast activation protein alpha binding agent	1
ISCALIMAB	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
SIPLIZUMAB	CD2	Antibody	INHIBITOR	T-cell surface antigen CD2 inhibitor	2
ORDESEKIMAB	IL15	Antibody	INHIBITOR	Interleukin-15 inhibitor	2

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3130

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs